{"artifact":{"id":"paper-fig-paper-828b7c4fa9a6-2","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 2 — C1q propagates microglial activation and neurodegeneration in the visual axis fo","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-828b7c4fa9a6\", \"timestamp\": \"2026-04-22T01:29:42.452546\"}]","content_hash":null,"metadata":{"pmid":"paper-828b7c4fa9a6","caption":"Local ischemic injury in the retina increases expression of C1q in the SC. ( a ) Representative images displaying differences in C1q expression between hemispheres of the SC 7 days following retinal I/R. Yellow outline indicates area of SC measured, scale = 20×. ( b ) Quantification of fluorescence intensity indicated significant differences between ipsilateral (uninjured) and contralateral (ischemic) hemispheres on days 7 and 28 ( p  < 0.01). C1q expression was greatest on day 28 in both hemispheres of the SC, and significantly different versus all time points assessed. Mean ± SEM,  n  = 7 per time point. ** p  < 0.01 using student’s paired  t -test between hemispheres within a time point, # p  < 0.05 ## p  < 0.01 compared across time points within a group determined via One-way ANOVA followed by Holm-Sidak post test. Scale bars = 100 μm","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC4806521/bin/13024_2016_89_Fig2_HTML.jpg","paper_title":"C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury.","figure_label":"Fig. 2","figure_number":2,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"e8ca5770-2e16-4db2-9558-a31f62b6d3aa","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-828b7c4fa9a6-2","is_canonical":true,"supersede_chain":["paper-fig-paper-828b7c4fa9a6-2"]}