{"artifact":{"id":"paper-fig-paper-828b7c4fa9a6-4","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 4 — C1q propagates microglial activation and neurodegeneration in the visual axis fo","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-828b7c4fa9a6\", \"timestamp\": \"2026-04-22T01:29:42.453864\"}]","content_hash":null,"metadata":{"pmid":"paper-828b7c4fa9a6","caption":"Retinal I/R activates and increases glial cell populations in the SC. Representative images demonstrate differences observed in astrocytes ( a ), ( b ) and microglia ( c ), ( d ) between uninjured ipsilateral and I/R-receiving contralateral hemispheres of the SC. ( e ) Quantification of microglial density was observed to be significantly different between hemispheres on days 7 and 14 ( p  < 0.01) following I/R. No differences were detected between hemispheres by 21 days post injury. However, a statistically significant difference was determined in the uninjured ipsilateral hemisphere when days 21 ( p  < 0.01) and 28 ( p  < 0.001) were compared to earlier time points. ( f ) Density of GFAP +  astrocytes was quantified; however, no significant differences could be determined between SC hemispheres at any time point following retinal I/R. However, statistical differences ( p  < 0.05) were observed in both ipsilateral and contralateral hemispheres when day 28 was compared against astrocyte","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC4806521/bin/13024_2016_89_Fig4_HTML.jpg","paper_title":"C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury.","figure_label":"Fig. 4","figure_number":4,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"4be9deed-659e-42e7-b254-9d8c81abc067","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-828b7c4fa9a6-4","is_canonical":true,"supersede_chain":["paper-fig-paper-828b7c4fa9a6-4"]}