{"artifact":{"id":"paper-fig-paper-828b7c4fa9a6-5","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 5 — C1q propagates microglial activation and neurodegeneration in the visual axis fo","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-828b7c4fa9a6\", \"timestamp\": \"2026-04-22T01:29:42.454474\"}]","content_hash":null,"metadata":{"pmid":"paper-828b7c4fa9a6","caption":"C1qa -deficiency protects against retinal thinning resulting from ischemic injury. ( a ) Representative H&E stained retinal cross-section images demonstrating the differences in retinal morphology observed in animals receiving retinal I/R injury compared with an uninjured retina. Retinas from WT mice were observed to have significant thinning of the IPL and INL, as well as dramatic loss of the NFL. However, retinas from  C1qa \n +/−  and  C1qa \n −/−  showed no visible changes in thickness. ( b ) Retinal layer thickness analysis of the whole retinal, the inner plexiform layer (IPL), inner nuclear layer (INL), and outer nuclear layer (ONL). A significant difference was determined between control and WT retinas ( p  < 0.01) in all layers measured except for the ONL. This difference was not observed in  C1qa \n +/−  and  C1qa \n −/−  retinas. Further, a significant rescue of retinal thickness could be seen between WT,  C1qa \n +/− , and  C1qa \n −/−  animals in the whole retina ( p  < 0.01) and","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC4806521/bin/13024_2016_89_Fig5_HTML.jpg","paper_title":"C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury.","figure_label":"Fig. 5","figure_number":5,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"ce225f39-4866-48c2-bd2f-861468227166","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-828b7c4fa9a6-5","is_canonical":true,"supersede_chain":["paper-fig-paper-828b7c4fa9a6-5"]}