{"artifact":{"id":"paper-fig-paper-828b7c4fa9a6-6","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 6 — C1q propagates microglial activation and neurodegeneration in the visual axis fo","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-828b7c4fa9a6\", \"timestamp\": \"2026-04-22T01:29:42.456086\"}]","content_hash":null,"metadata":{"pmid":"paper-828b7c4fa9a6","caption":"C1qa -deficiency mitigates loss of RGCs using two independent assays of cell counts 28 days following retinal I/R. ( a ) H&E stained and ( c ) Rbpms-immunolabeled retinal cross sections used to assess RGC loss between uninjured controls and three  C1qa  genetic backgrounds receiving ischemic injury. ( b ) Quantification of nuclei counted in the GCL determined there was a significant loss of cells ( p  < 0.01) in WT retinas but not in the  C1qa -deficient retinas compared to control. ( d ) Counts of Rbpms +  RGCs displayed a statistically significant loss ( p  < 0.01) in ischemic eyes of WT mice compared to controls. No statistical differences were determined in ischemic retinas of  C1qa \n +/−  or  C1qa \n −/−  animals. However, a statistical difference ( p  < 0.01) was measured when  C1qa \n −/−  retinas were compared to WT. Mean ± SEM,  n  = 7 per group. ** p  < 0.01 compared to control and ## p  < 0.01 compared to WT – I/R determined by One-way ANOVA followed by Holm-Sidak post test. S","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC4806521/bin/13024_2016_89_Fig6_HTML.jpg","paper_title":"C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury.","figure_label":"Fig. 6","figure_number":6,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"84778a78-2f92-49b9-8827-b5b68fb81c9b","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-828b7c4fa9a6-6","is_canonical":true,"supersede_chain":["paper-fig-paper-828b7c4fa9a6-6"]}