{"artifact":{"id":"paper-fig-paper-828b7c4fa9a6-7","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 7 — C1q propagates microglial activation and neurodegeneration in the visual axis fo","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-828b7c4fa9a6\", \"timestamp\": \"2026-04-22T01:29:42.457410\"}]","content_hash":null,"metadata":{"pmid":"paper-828b7c4fa9a6","caption":"C1q -deficiency delays loss of visual function due to retinal I/R. ( a ) Representative ERG traces observed in WT mice comparing waveforms from ischemic and uninjured eyes across a series of flash intensities tested 28 days post injury. ( b ) Comparison of b-wave amplitudes over a 28 day time course at an intensity of 3000 mcd.s/m 2 . A statistically significant loss of b-wave response was observed in WT ( p  < 0.01) and  C1qa \n +/-  ( p  < 0.05) ischemic eyes compared to uninjured controls at all time points. However, following initial b-wave suppression,  C1qa \n -/-  ischemic eyes displayed a significant rescue ( p  < 0.05) on day 14. This rescue was transient as a slight decline was observed over the remaining two time points; by the end no statistical differences were observed between any animals receiving ischemic injury. Mean ± SEM,  n  = 8 per group. * p  < 0.05 ** p  < 0.01 *** p  < 0.001 compared to control # p  < 0.05 comared to WT–I/R determined by One-way ANOVA followed by ","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC4806521/bin/13024_2016_89_Fig7_HTML.jpg","paper_title":"C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury.","figure_label":"Fig. 7","figure_number":7,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"4906ab1e-d6af-4b1c-b3cd-8643a40d435a","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-828b7c4fa9a6-7","is_canonical":true,"supersede_chain":["paper-fig-paper-828b7c4fa9a6-7"]}