{"artifact":{"id":"paper-fig-paper-862a1a9ceb7a-14","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 5 — B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4.","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-862a1a9ceb7a\", \"timestamp\": \"2026-04-22T01:29:41.554465\"}]","content_hash":null,"metadata":{"pmid":"paper-862a1a9ceb7a","caption":"AQP4-specific T cell precursor frequencies in  Aqp4 ΔB  mice, but not in  Aqp4 ΔTEC  mice, are sufficient to cause overt autoimmune disease in response to an antigen-specific trigger. In contrast to WT mice and  Aqp4 ΔTEC  mice,  Aqp4 ΔB  mice were susceptible to EAE after immunization with P41 in CFA (see also Extended Data Fig.  6a–c ).  a , EAE incidence (left) and mean ± s.e.m. disease severity (right) in all P41-immunized WT,  Aqp4 ΔTEC  and  Aqp4 ΔB  mice.  b , EAE incidence in all MOG(35–55)-immunized and P41-immunized WT mice and  Aqp4 ΔB  mice.  c , The mean ± s.e.m. disease severity in clinically sick MOG(35–55)-immunized and clinically sick P41-immunized  Aqp4 ΔB  mice. Statistical analysis was performed using Mantel–Cox log-rank tests and two-way ANOVA with Sidak’s post test to compare incidences and disease course, respectively. Only the relevant tests are indicated in  b  for legibility.  d , Representative CD45 stainings of the optic nerve and retina in MOG(35–55)-immuni","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC10937377/bin/41586_2024_7079_Fig5_HTML.jpg","paper_title":"B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4.","figure_label":"Fig. 5","figure_number":14,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"171a005e-4ebb-41d2-a20e-d968bd4272ef","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-862a1a9ceb7a-14","is_canonical":true,"supersede_chain":["paper-fig-paper-862a1a9ceb7a-14"]}