{"artifact":{"id":"paper-fig-paper-d6a9c1913c3a-3","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 3 — An integrative analysis of single-cell and bulk transcriptome and bidirectional ","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-d6a9c1913c3a\", \"timestamp\": \"2026-04-22T01:29:41.573298\"}]","content_hash":null,"metadata":{"pmid":"paper-d6a9c1913c3a","caption":"The expression and signaling pathways involved in characteristic genes in scRNA-seq.  (A–C)  The plots display the expression of C1QA, C1QC and SPI1 in cell clusters using scRNA-seq.  (D)  The three characteristic genes were upregulated in AC group.  (E)  The GSEA showed that the signaling pathways in all 12 cells clusters.  (F)  The KEGG plot shows the KEGG pathway in macrophage clusters.","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC10764496/bin/fimmu-14-1289223-g003.jpg","paper_title":"An integrative analysis of single-cell and bulk transcriptome and bidirectional mendelian randomization analysis identified C1Q as a novel stimulated risk gene for Atherosclerosis.","figure_label":"Figure 3","figure_number":3,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"d5ecfea9-0c67-4f17-a5c5-e108c16032a1","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-d6a9c1913c3a-3","is_canonical":true,"supersede_chain":["paper-fig-paper-d6a9c1913c3a-3"]}