{"artifact":{"id":"paper-fig-paper-de0f65fde5fe-3","artifact_type":"paper_figure","entity_ids":"[]","title":"FIGURE 3 — The extracellular matrix component perlecan/HSPG2 regulates radioresistance in p","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-de0f65fde5fe\", \"timestamp\": \"2026-04-22T01:29:41.534798\"}]","content_hash":null,"metadata":{"pmid":"paper-de0f65fde5fe","caption":"The expression levels of HSPG2, LOXL2, LAMB3, and SRPX genes correlate with the clinical outcomes and cell radioresistance.  (A)  The Kaplan-Meier analyses of the association of HSPG2, LOXL2, LAMB3, and SRPX gene expression and biochemical recurrence-free survival (BRFS) in the TCGA PRAD PC gene expression dataset (N = 407). The stratification of patients into “high” and “low” groups according to gene expression was obtained using the online tool R2 Platform ( https://hgserver1.amc.nl/cgi-bin/r2/main.cgi?option=kaplan_main ). The numbers on the  x -axis represent time in years. Numbers at risk are added to the bottom of each graph.  (B)  RT-qPCR analysis of the relative HSPG2, LOXL2, SRPX, and LAMB3 mRNA expression in DU145 P and RR cells. N = 3; Error bars = SD; ** p  < 0.01; *** p  < 0.001.  (C)  Correlation of HSPG2, LOXL2, SRPX, and LAMB3 mRNA expression levels in normal tissues (MSKCC dataset, n = 29), primary tumors (MSKCC dataset, n = 131), and metastatic tumors (MSKCC dataset, ","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11325029/bin/fcell-12-1452463-g003.jpg","paper_title":"The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells.","figure_label":"FIGURE 3","figure_number":3,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"3d129817-4f58-45c2-8925-61fadb29ec69","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-de0f65fde5fe-3","is_canonical":true,"supersede_chain":["paper-fig-paper-de0f65fde5fe-3"]}