{"artifact":{"id":"paper-fig-paper-de0f65fde5fe-4","artifact_type":"paper_figure","entity_ids":"[]","title":"FIGURE 4 — The extracellular matrix component perlecan/HSPG2 regulates radioresistance in p","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-de0f65fde5fe\", \"timestamp\": \"2026-04-22T01:29:41.536232\"}]","content_hash":null,"metadata":{"pmid":"paper-de0f65fde5fe","caption":"Radiobiological colony formation assay (CFA).  (A)  CFA for the DU145 parental (P) cells after siRNA-mediated knockdown of HSPG2, LOXL2, LAMB3, or SRPX. Cells transfected with scrambled (Scr) siRNA were used as controls. Data are mean ± SD; * p  < 0.05; *** p  < 0.001.  (B)  CFA for the DU145 radioresistant (RR) cells after siRNA-mediated knockdown of HSPG2, LOXL2, LAMB3, or SRPX. Cells transfected with scrambled siRNA (Scr siRNA) were used as controls. Data are mean ± SD; * p  < 0.05; *** p  < 0.001.","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11325029/bin/fcell-12-1452463-g004.jpg","paper_title":"The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells.","figure_label":"FIGURE 4","figure_number":4,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"42416ba0-783a-4c7e-a0e2-dbddb207f7ae","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-de0f65fde5fe-4","is_canonical":true,"supersede_chain":["paper-fig-paper-de0f65fde5fe-4"]}