{"artifact":{"id":"paper-fig-paper-eba56eb9e84f-3","artifact_type":"paper_figure","entity_ids":"[]","title":"FIGURE 3 — Calcium Deregulation: Novel Insights to Understand Friedreich's Ataxia Pathophys","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-eba56eb9e84f\", \"timestamp\": \"2026-04-22T01:29:42.632796\"}]","content_hash":null,"metadata":{"pmid":"paper-eba56eb9e84f","caption":"Failure to restore Ca 2+  homeostasis after depolarization in YG8R CGNs.  (A–C)  CGNs were loaded with Fluo4-AM  (A)  and challenged with 30 mM KCL  (B) , amplitudes were measured and showed a higher response in YG8R than Control ( C ;  ∗ p  < 0.05).  (D,E)  CGNs response to 1 μM Thapsigargin and 1mM CaCl 2 , and relative amplitudes ( ∗∗∗ p  < 0.0005). Scale bar (20 μm).","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC6176067/bin/fncel-12-00264-g003.jpg","paper_title":"Calcium Deregulation: Novel Insights to Understand Friedreich's Ataxia Pathophysiology.","figure_label":"FIGURE 3","figure_number":3,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"f9bcbac0-df92-4ee3-bf54-82b0fc55071d","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-eba56eb9e84f-3","is_canonical":true,"supersede_chain":["paper-fig-paper-eba56eb9e84f-3"]}