{"artifact":{"id":"paper-fig-paper-eba56eb9e84f-4","artifact_type":"paper_figure","entity_ids":"[]","title":"FIGURE 4 — Calcium Deregulation: Novel Insights to Understand Friedreich's Ataxia Pathophys","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-eba56eb9e84f\", \"timestamp\": \"2026-04-22T01:29:42.633513\"}]","content_hash":null,"metadata":{"pmid":"paper-eba56eb9e84f","caption":"FxnKD induces a smaller caffeine response and RyRs potentiation.  (A,B)  HL-1 cells FxnKD shows a smaller caffeine response compared to Scr cells.  (A)  Shows the kinetic of an average of cells and  (B)  reports the full sets of experiments combined together showing the decreased amplitude in FxnKD cells ( ∗∗ p  < 0.005).  (C,D)  Highlight phase II of the Ca 2+  response in Scr cells and in FxnKD cells. Showing an early end of the Ca 2+  response probably ascribed to energy failure.  (E,F)  In H9c2 cells the diminished caffeine response in FxnKD was even more marked than HL-1 cells, however, the second phase of Ca 2+  response was flat and the receptors saturated ( ∗∗ p  < 0.005).","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC6176067/bin/fncel-12-00264-g004.jpg","paper_title":"Calcium Deregulation: Novel Insights to Understand Friedreich's Ataxia Pathophysiology.","figure_label":"FIGURE 4","figure_number":4,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"4bdc69ea-657d-46bc-ab1e-86369cfb25ef","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-eba56eb9e84f-4","is_canonical":true,"supersede_chain":["paper-fig-paper-eba56eb9e84f-4"]}