{"artifact":{"id":"paper-figure-41890637-1","artifact_type":"paper_figure","entity_ids":null,"title":"Figure 1 from PMID:41890637","quality_score":0.95,"created_by":null,"provenance_chain":null,"content_hash":null,"metadata":{"pmid":"41890637","pmc_id":"PMC13013429","caption":"Relationship between syndromic and non-syndromic ASD and their genetic underpinnings. The left circle represents syndromic ASD, where autism spectrum disorder (ASD) symptoms occur as part of a broader clinical syndrome. Examples include Angelman syndrome (UBE3A), Rett syndrome (MECP2), Fragile X syndrome (FMR1), Phelan-McDermid syndrome (SHANK3), and Tuberous Sclerosis Complex (TSC1, TSC2). In these cases, ASD is considered a component of the syndrome. The right circle represents non-syndromic ASD, characterized by isolated ASD without additional syndromic features. High-risk genes associated with non-syndromic ASD include CNTNAP2, GRIN2B, CHD8, SCN2A, PTEN, and SHANK3. Notably, SHANK3 mutations can also occur in ASD patients without Phelan-McDermid syndrome, indicating that a single gene mutation may lead to ASD alone. The overlapping region highlights shared molecular pathways, such as synapse formation, synaptic pruning, and ubiquitination, demonstrating that different genetic backg","image_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013429/figure/F1/","figure_label":"Figure 1","figure_number":1,"_schema_version":1},"created_at":"2026-04-13T06:15:46-07:00","updated_at":"2026-04-16T21:10:08.528104-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-13T06:15:46-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"eaaff8b1-f4f4-481b-a063-c93e42ac08ca","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"system"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-41890637","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 41890637"}],"incoming_links":[],"current_artifact_id":"paper-figure-41890637-1","is_canonical":true,"supersede_chain":["paper-figure-41890637-1"]}