{"artifact":{"id":"rsc-h-54c6dd37ce-bca4cf11","artifact_type":"rigor_score_card","entity_ids":null,"title":"Rigor Score Card: TFEB/TFE3 Parallel Activation Drives Coordinated Organelle Clearance via CLEAR Network","quality_score":0.275,"created_by":"rigor_score_card","provenance_chain":"[{\"artifact_id\": \"h-54c6dd37ce\", \"relation\": \"scores\"}]","content_hash":null,"metadata":{"dimensions":["scientific_premise","study_design","blinding","power_analysis","resource_identification","statistical_reporting","data_availability","sabv"],"eval_a_raw":{"scores":{"sabv":{"score":1,"evidence":"No mention of sex considerations, disaggregation by sex, or SABV analysis","location":"Not applicable - no primary data presented"},"blinding":{"score":1,"evidence":"No mention of assessor blinding, randomization, or blinding procedures","location":"Not applicable - no primary data presented"},"study_design":{"score":1,"evidence":"EVALUATION TARGET: Type: hypothesis","location":"Document header"},"power_analysis":{"score":1,"evidence":"No mention of sample size calculations, power analysis, or statistical power justification","location":"Not applicable - no primary data presented"},"data_availability":{"score":1,"evidence":"No mention of data or code availability, no links to repositories or datasets","location":"Not applicable - no primary data presented"},"scientific_premise":{"score":4,"evidence":"The CLEAR (Coordinated Lysosomal Expression and Regulation) network encompasses >400 autophagy-lysosome genes, providing the transcriptional framework for both shared and organelle-specific quality control programs (26942069).","location":"Hypothesis statement"},"statistical_reporting":{"score":1,"evidence":"No statistical tests, thresholds, corrections, or assumptions reported","location":"Not applicable - no primary data presented"},"resource_identification":{"score":1,"evidence":"only general references to studies, no RRID or specific reagent identification","location":"Not applicable - no primary data presented"}},"overall_summary":"This is a hypothesis-generating text summarizing literature on TFEB/TFE3 signaling, not a primary research study. It cannot be evaluated for standard biomedical rigor criteria (study design, power, blinding, statistics) because these elements are absent by design. The scientific premise is reasonable, citing prior literature and acknowledging knowledge gaps, but the text lacks the structural elements required for full methodological assessment.","weakest_dimension":"study_design","strongest_dimension":"scientific_premise"},"eval_b_raw":{"scores":{"sabv":{"score":1,"evidence":"No mention of sex as biological variable or disaggregated analysis","location":"No mention"},"blinding":{"score":1,"evidence":"No mention of blinding or assessor independence","location":"No mention"},"study_design":{"score":1,"evidence":"This text is a hypothesis statement rather than a study report—contains no design specification","location":"Title: hypothesis"},"power_analysis":{"score":1,"evidence":"No statistical power justification or sample size rationale","location":"No mention"},"data_availability":{"score":1,"evidence":"No data or code accessibility statement","location":"No mention"},"scientific_premise":{"score":3,"evidence":"Citations to multiple PMIDs (26942069, 31501761, 29045917, 31801954, 29311652) provide grounding in prior work","location":"First sentence and throughout"},"statistical_reporting":{"score":1,"evidence":"No statistical tests, thresholds, or corrections reported","location":"No mention"},"resource_identification":{"score":1,"evidence":"No RRIDs or catalog numbers for reagents/cell lines/datasets","location":"No mention"}},"overall_summary":"This text is a hypothesis framing rather than a study report, scoring highest only for scientific premise (citing prior literature) but deficient across all methodological dimensions including study design, blinding, power analysis, resource identification, statistical reporting, data availability, and SABV consideration.","weakest_dimension":"study_design","strongest_dimension":"scientific_premise"},"provider_a":"minimax","provider_b":"glm","reconciled":{"reconciler_notes":"Both evaluators achieved perfect concordance (7/8 dimensions) and near-concordance on scientific_premise (A=4, B=3, |diff|=1, averaged to 4). All 8 evidence quotes exceed the 10-character minimum and are thus valid. The text is correctly identified as a hypothesis-generating framing, not a primary research study, which appropriately results in low scores across methodological rigor dimensions (blinding, power, statistics, data availability, SABV) that are not applicable by design. The only substantive dimension—scientific_premise—was scored conservatively at 4, reflecting the citation of prior literature (PMIDs) and acknowledgment of knowledge gaps.","overall_agreement":"high","reconciled_scores":{"sabv":{"score":1,"a_score":1,"b_score":1,"a_evidence":"No mention of sex considerations, disaggregation by sex, or SABV analysis","b_evidence":"No mention of sex as biological variable or disaggregated analysis","disagreement":false},"blinding":{"score":1,"a_score":1,"b_score":1,"a_evidence":"No mention of assessor blinding, randomization, or blinding procedures","b_evidence":"No mention of blinding or assessor independence","disagreement":false},"study_design":{"score":1,"a_score":1,"b_score":1,"a_evidence":"EVALUATION TARGET: Type: hypothesis","b_evidence":"This text is a hypothesis statement rather than a study report—contains no design specification","disagreement":false},"power_analysis":{"score":1,"a_score":1,"b_score":1,"a_evidence":"No mention of sample size calculations, power analysis, or statistical power justification","b_evidence":"No statistical power justification or sample size rationale","disagreement":false},"data_availability":{"score":1,"a_score":1,"b_score":1,"a_evidence":"No mention of data or code availability, no links to repositories or datasets","b_evidence":"No data or code accessibility statement","disagreement":false},"scientific_premise":{"score":4,"a_score":4,"b_score":3,"a_evidence":"The CLEAR (Coordinated Lysosomal Expression and Regulation) network encompasses >400 autophagy-lysosome genes, providing the transcriptional framework for both shared and organelle-specific quality control programs (26942069).","b_evidence":"Citations to multiple PMIDs (26942069, 31501761, 29045917, 31801954, 29311652) provide grounding in prior work","disagreement":false},"statistical_reporting":{"score":1,"a_score":1,"b_score":1,"a_evidence":"No statistical tests, thresholds, corrections, or assumptions reported","b_evidence":"No statistical tests, thresholds, or corrections reported","disagreement":false},"resource_identification":{"score":1,"a_score":1,"b_score":1,"a_evidence":"only general references to studies, no RRID or specific reagent identification","b_evidence":"No RRIDs or catalog numbers for reagents/cell lines/datasets","disagreement":false}},"inter_rater_agreement":"1.0","dimensions_with_disagreement":[]},"_schema_version":1,"scored_entity_id":"h-54c6dd37ce","scored_entity_type":"hypothesis","scored_entity_title":"TFEB/TFE3 Parallel Activation Drives Coordinated Organelle Clearance via CLEAR Network"},"created_at":"2026-04-22T13:49:03.480320-07:00","updated_at":"2026-04-22T13:49:03.480322-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-22T13:49:03.480320-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"6c32c5e3-e1ed-4ac6-9539-20c740bf3561","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"rigor_score_card"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"rsc-h-54c6dd37ce-bca4cf11","is_canonical":true,"supersede_chain":["rsc-h-54c6dd37ce-bca4cf11"]}