{"artifact":{"id":"rsc-h-SDA-2026-04-26-gap-b7a80f6b","artifact_type":"rigor_score_card","entity_ids":null,"title":"Rigor Score Card: ER-Associated Degradation (ERAD) Cross-Activation","quality_score":0.225,"created_by":"rigor_score_card","provenance_chain":"[{\"artifact_id\": \"h-SDA-2026-04-26-gap-pubmed-20260412-094853-199f4f1b-05-er-associated-degradation-erad-cross-activation-59318f6175\", \"relation\": \"scores\"}]","content_hash":null,"metadata":{"dimensions":["scientific_premise","study_design","blinding","power_analysis","resource_identification","statistical_reporting","data_availability","sabv"],"eval_a_raw":{"scores":{"sabv":{"score":1,"evidence":"No mention of sex as a biological variable or disaggregation by sex.","location":"Not applicable"},"blinding":{"score":1,"evidence":"No mention of blinding or assessor independence.","location":"Not applicable"},"study_design":{"score":1,"evidence":"ISRIB provides a direct pharmacological test of this mechanism.","location":"Paragraph 2"},"power_analysis":{"score":1,"evidence":"No mention of statistical power analysis or sample size justification.","location":"Not applicable"},"data_availability":{"score":1,"evidence":"No mention of data sharing, code repositories, or raw data access.","location":"Not applicable"},"scientific_premise":{"score":2,"evidence":"Partial translation of intron-retained GBA transcripts produces misfolded peptide fragments that mislocalize to the ER membrane rather than entering the ER lumen, causing local ER stress.","location":"Paragraph 1"},"statistical_reporting":{"score":1,"evidence":"No statistical methods, tests, thresholds, or corrections described.","location":"Not applicable"},"resource_identification":{"score":1,"evidence":"No RRID or catalog numbers for reagents, cell lines, or animal models mentioned.","location":"Not applicable"}},"overall_summary":"This text presents a mechanistic hypothesis about ERAD cross-activation in GBA but lacks fundamental methodological rigor markers: zero citations to prior work, no knowledge gap articulation, no study design, no statistical planning, no reagent identification, and no data/code sharing commitments. The mechanistic logic is internally consistent but cannot be evaluated for reproducibility without specific experimental parameters.","weakest_dimension":"study_design — the text claims ISRIB as a pharmacological test without describing any experimental design, control groups, or outcome measures","strongest_dimension":"scientific_premise — the mechanism has coherent biological plausibility (PERK-eIF2α-GBA axis) but is undermined by absence of citations"},"eval_b_raw":{"scores":{"sabv":{"score":1,"evidence":"No mention of sex as a biological variable or disaggregated analyses.","location":"Entire text"},"blinding":{"score":1,"evidence":"No mention of assessors, analysts, or outcome evaluation methods.","location":"Entire text"},"study_design":{"score":1,"evidence":"ISRIB provides a direct pharmacological test of this mechanism.","location":"Hypothesis statement paragraph 2"},"power_analysis":{"score":1,"evidence":"No statistical methods, power calculations, or sample size justifications mentioned.","location":"Entire text"},"data_availability":{"score":1,"evidence":"No data or code presented; this is a mechanistic hypothesis without empirical results.","location":"Entire text"},"scientific_premise":{"score":2,"evidence":"Partial translation of intron-retained GBA transcripts produces misfolded peptide fragments that mislocalize to the ER membrane rather than entering the ER lumen, causing local ER stress.","location":"Hypothesis statement paragraph 1"},"statistical_reporting":{"score":1,"evidence":"No statistical tests, thresholds, corrections, or assumptions reported.","location":"Entire text"},"resource_identification":{"score":1,"evidence":"No reagents, cell lines, animal models, or datasets identified by name or RRID.","location":"Entire text"}},"overall_summary":"This text presents a mechanistic hypothesis for ERAD cross-activation involving GBA, PERK, and eIF2α, but lacks any experimental design, statistical methods, resource identification, or data. It describes a proposed chain of molecular events without citing supporting literature or proposing how ISRIB would actually be used to test the hypothesis. As a hypothesis statement, it cannot be evaluated against study design, blinding, power, or data availability standards—but it notably fails to articulate even a proposed experimental approach.","weakest_dimension":"study_design","strongest_dimension":"scientific_premise"},"provider_a":"minimax","provider_b":"minimax-alt","reconciled":{"reconciler_notes":"Perfect agreement between evaluators A and B across all 8 dimensions. Both gave identical scores (2 for scientific_premise, 1 for all other dimensions) and provided consistent evidence citations. Cohen's kappa = 1.0 indicating absolute inter-rater reliability. No disagreements required resolution. The reconciled card reflects unanimous assessment: the text presents a plausible but unverified mechanistic hypothesis for ERAD cross-activation involving GBA/PERK/eIF2α, but lacks any experimental design, statistical planning, resource identification, or data availability commitments.","overall_agreement":"high","reconciled_scores":{"sabv":{"score":1,"a_score":1,"b_score":1,"a_evidence":"No mention of sex as a biological variable or disaggregation by sex.","b_evidence":"No mention of sex as a biological variable or disaggregated analyses.","disagreement":false},"blinding":{"score":1,"a_score":1,"b_score":1,"a_evidence":"No mention of blinding or assessor independence.","b_evidence":"No mention of assessors, analysts, or outcome evaluation methods.","disagreement":false},"study_design":{"score":1,"a_score":1,"b_score":1,"a_evidence":"ISRIB provides a direct pharmacological test of this mechanism.","b_evidence":"ISRIB provides a direct pharmacological test of this mechanism.","disagreement":false},"power_analysis":{"score":1,"a_score":1,"b_score":1,"a_evidence":"No mention of statistical power analysis or sample size justification.","b_evidence":"No statistical methods, power calculations, or sample size justifications mentioned.","disagreement":false},"data_availability":{"score":1,"a_score":1,"b_score":1,"a_evidence":"No mention of data sharing, code repositories, or raw data access.","b_evidence":"No data or code presented; this is a mechanistic hypothesis without empirical results.","disagreement":false},"scientific_premise":{"score":2,"a_score":2,"b_score":2,"a_evidence":"Partial translation of intron-retained GBA transcripts produces misfolded peptide fragments that mislocalize to the ER membrane rather than entering the ER lumen, causing local ER stress.","b_evidence":"Partial translation of intron-retained GBA transcripts produces misfolded peptide fragments that mislocalize to the ER membrane rather than entering the ER lumen, causing local ER stress.","disagreement":false},"statistical_reporting":{"score":1,"a_score":1,"b_score":1,"a_evidence":"No statistical methods, tests, thresholds, or corrections described.","b_evidence":"No statistical tests, thresholds, corrections, or assumptions reported.","disagreement":false},"resource_identification":{"score":1,"a_score":1,"b_score":1,"a_evidence":"No RRID or catalog numbers for reagents, cell lines, or animal models mentioned.","b_evidence":"No reagents, cell lines, animal models, or datasets identified by name or RRID.","disagreement":false}},"inter_rater_agreement":"1.0","dimensions_with_disagreement":[]},"_schema_version":1,"scored_entity_id":"h-SDA-2026-04-26-gap-pubmed-20260412-094853-199f4f1b-05-er-associated-degradation-erad-cross-activation-59318f6175","scored_entity_type":"hypothesis","scored_entity_title":"ER-Associated Degradation (ERAD) Cross-Activation"},"created_at":"2026-04-27T01:18:37.664702-07:00","updated_at":"2026-04-27T01:18:37.664706-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"b583d278-7e8f-4a97-85a1-01a1ad9d0ba6","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"rigor_score_card"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"rsc-h-SDA-2026-04-26-gap-b7a80f6b","is_canonical":true,"supersede_chain":["rsc-h-SDA-2026-04-26-gap-b7a80f6b"]}