{"artifact":{"id":"rsc-h-SDA-2026-04-26-gap-f1f49950","artifact_type":"rigor_score_card","entity_ids":null,"title":"Rigor Score Card: Nuclear Export Sequestration and Cytoplasmic Depletion","quality_score":0.225,"created_by":"rigor_score_card","provenance_chain":"[{\"artifact_id\": \"h-SDA-2026-04-26-gap-pubmed-20260412-094853-199f4f1b-06-nuclear-export-sequestration-and-cytoplasmic-dep-04e02127c2\", \"relation\": \"scores\"}]","content_hash":null,"metadata":{"dimensions":["scientific_premise","study_design","blinding","power_analysis","resource_identification","statistical_reporting","data_availability","sabv"],"eval_a_raw":{"scores":{"sabv":{"score":1,"evidence":"No mention of sex as a biological variable, no disaggregated results by sex, no sample size breakdown by sex.","location":"Hypothesis statement"},"blinding":{"score":1,"evidence":"No mention of blinding or assessor independence. This is a theoretical model, not an empirical study.","location":"Hypothesis statement"},"study_design":{"score":1,"evidence":"This text is a hypothesis statement describing a proposed mechanism. No study design elements (cohort, RCT, observational, in-vitro, etc.) are described.","location":"Hypothesis statement"},"power_analysis":{"score":1,"evidence":"No statistical methods, sample size justification, or power calculations are mentioned. This is a speculative model without quantitative study parameters.","location":"Hypothesis statement"},"data_availability":{"score":1,"evidence":"No data or code availability statements, no raw data, no analysis pipeline, and no repository links.","location":"Hypothesis statement"},"scientific_premise":{"score":2,"evidence":"Retained intronic sequences contain cryptic nuclear retention elements that recruit export inhibitory complexes (PHAX, AlyREF, UAP56), sequestering the TREX complex","location":"Hypothesis statement"},"statistical_reporting":{"score":1,"evidence":"No statistical tests, significance thresholds, multiple testing corrections, or assumptions are reported.","location":"Hypothesis statement"},"resource_identification":{"score":1,"evidence":"No reagents, cell lines, antibodies, datasets, or organisms are identified with RRID or unique identifiers.","location":"Hypothesis statement"}},"overall_summary":"This is a speculative hypothesis/model rather than a study report. The text proposes a mechanism involving TREX complex sequestration but lacks all empirical supporting evidence, statistical rigor, and transparency elements required for biomedical research claims. 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