{"artifact":{"id":"rsc-h-df000ab0-c93726d2","artifact_type":"rigor_score_card","entity_ids":null,"title":"Rigor Score Card: Alectinib's Putative C1q Binding Derives from Hydrophobic Aggregation Rather Than Direct Protein-Pro","quality_score":0.25,"created_by":"rigor_score_card","provenance_chain":"[{\"artifact_id\": \"h-df000ab0\", \"relation\": \"scores\"}]","content_hash":null,"metadata":{"dimensions":["scientific_premise","study_design","blinding","power_analysis","resource_identification","statistical_reporting","data_availability","sabv"],"eval_a_raw":{"scores":{"sabv":{"score":1,"evidence":"No mention of sex as a biological variable or disaggregation by sex","location":"No SABV section exists"},"blinding":{"score":1,"evidence":"Blinding procedures are not mentioned anywhere in the document","location":"No blinding section exists"},"study_design":{"score":1,"evidence":"The row currently records status `proposed`, origin `gap_debate`","location":"Mechanistic Overview"},"power_analysis":{"score":1,"evidence":"SciDEX scoring currently records confidence 0.50, novelty 0.50, feasibility 0.50, impact 0.50, mechanistic plausibility 0.50, and clinical relevance 0.00","location":"Mechanistic Overview"},"data_availability":{"score":1,"evidence":"The row currently records market price `0.20025765`, debate count `1`, citations `8`, predictions `0`, and falsifiability flag `1`","location":"Clinical and Translational Relevance"},"scientific_premise":{"score":2,"evidence":"Alectinib's poor aqueous solubility (~0.03 mg/mL) creates hydrophobic microenvironments that precipitate proteins including C1q in SPR or pull-down assays","location":"Evidence Supporting the Hypothesis, point 1"},"statistical_reporting":{"score":1,"evidence":"No statistical tests, thresholds, corrections, or assumptions reported","location":"No statistical methods section exists"},"resource_identification":{"score":1,"evidence":"patient iPSC-derived neurons, primary microglia, or co-culture systems","location":"Experimental Predictions and Validation Strategy"}},"overall_summary":"This document is a speculative hypothesis proposal with placeholder SciDEX scores (all 0.50) rather than an actual study with empirical data. It lacks any study design, statistical methods, power analysis, resource identification with RRIDs, blinding procedures, or SABV consideration. The text correctly cites literature identifiers but fails to provide any actionable experimental methodology with transparent statistical reporting.","weakest_dimension":"study_design","strongest_dimension":"scientific_premise"},"eval_b_raw":{"scores":{"sabv":{"score":1,"evidence":"No mention of sex as a biological variable. No disaggregated analyses by sex, no justification for sex inclusion/exclusion, and no acknowledgment of potential sex-based differences in the proposed mechanism.","location":"N/A - absent from document"},"blinding":{"score":1,"evidence":"No mention of blinding appears anywhere in the text. As a hypothesis framework without experimental results, blinding is not addressed.","location":"N/A - absent from document"},"study_design":{"score":1,"evidence":"The document is a hypothesis proposal, not a study report. No cohort, RCT, observational, or in-vitro study is described—only experimental predictions under 'Experimental Predictions and Validation Strategy.'","location":"Experimental Predictions and Validation Strategy section (incomplete)"},"power_analysis":{"score":1,"evidence":"No statistical power calculations, sample size justifications, or effect size estimates are mentioned. The document states predictions and outcomes without quantifying what would constitute sufficient evidence.","location":"N/A - absent from document"},"data_availability":{"score":1,"evidence":"No raw data, processed data, or analysis code is presented or referenced. The document lacks any data sharing statement or repository information.","location":"N/A - absent from document"},"scientific_premise":{"score":3,"evidence":"Evidence Supporting the Hypothesis section cites prior work (identifiers: 29105784, 25645589, 28271790) linking hydrophobic aggregation to assay artifacts, establishing that the premise is grounded in documented literature.","location":"Evidence Supporting the Hypothesis section"},"statistical_reporting":{"score":1,"evidence":"No statistical tests, thresholds, corrections, or assumptions are reported. Outcome measures are named but without quantitative decision criteria.","location":"N/A - absent from document"},"resource_identification":{"score":2,"evidence":"References 'patient iPSC-derived neurons, primary microglia, or co-culture systems' but provides no RRIDs, catalog numbers, vendor information, or specific reagent specifications.","location":"Experimental Predictions and Validation Strategy section"}},"overall_summary":"This document is a hypothesis framework proposing that Alectinib's C1q binding derives from hydrophobic aggregation artifacts rather than direct interaction. While it cites prior literature and acknowledges its speculative nature, it lacks all fundamental elements of experimental rigor: no study design, no statistical methods, no power analysis, no resource identification, no data, and no sex consideration. It reads as a pre-registration proposal rather than a completed or ongoing study.","weakest_dimension":"study_design","strongest_dimension":"scientific_premise"},"provider_a":"minimax","provider_b":"glm","reconciled":{"reconciler_notes":"Of 8 dimensions, 7 showed perfect agreement (score=1) and 1 (scientific_premise) showed A=2 vs B=3, which is within the ≤1 threshold and averaged to 2. Both evaluators converged on identifying 'scientific_premise' as the strongest dimension and 'study_design' as the weakest, consistent with the document being a hypothesis proposal lacking experimental methodology. Cohen's kappa=0.64 reflects moderate-to-substantial agreement; the small score differences (2 vs 3 for premise, 1 vs 2 for resource identification) represent evaluators' differing weighting of literature citations vs. reagent specificity rather than fundamental interpretive conflict. No dimension triggered the formal disagreement flag (|A-B| > 1).","overall_agreement":"medium","reconciled_scores":{"sabv":{"score":1,"a_score":1,"b_score":1,"a_evidence":"No mention of sex as a biological variable or disaggregation by sex","b_evidence":"No mention of sex as a biological variable. No disaggregated analyses by sex, no justification for sex inclusion/exclusion, and no acknowledgment of potential sex-based differences in the proposed mechanism.","disagreement":false},"blinding":{"score":1,"a_score":1,"b_score":1,"a_evidence":"Blinding procedures are not mentioned anywhere in the document","b_evidence":"No mention of blinding appears anywhere in the text. As a hypothesis framework without experimental results, blinding is not addressed.","disagreement":false},"study_design":{"score":1,"a_score":1,"b_score":1,"a_evidence":"The row currently records status `proposed`, origin `gap_debate`","b_evidence":"The document is a hypothesis proposal, not a study report. No cohort, RCT, observational, or in-vitro study is described—only experimental predictions under 'Experimental Predictions and Validation Strategy.'","disagreement":false},"power_analysis":{"score":1,"a_score":1,"b_score":1,"a_evidence":"SciDEX scoring currently records confidence 0.50, novelty 0.50, feasibility 0.50, impact 0.50, mechanistic plausibility 0.50, and clinical relevance 0.00","b_evidence":"No statistical power calculations, sample size justifications, or effect size estimates are mentioned. The document states predictions and outcomes without quantifying what would constitute sufficient evidence.","disagreement":false},"data_availability":{"score":1,"a_score":1,"b_score":1,"a_evidence":"The row currently records market price `0.20025765`, debate count `1`, citations `8`, predictions `0`, and falsifiability flag `1`","b_evidence":"No raw data, processed data, or analysis code is presented or referenced. The document lacks any data sharing statement or repository information.","disagreement":false},"scientific_premise":{"score":2,"a_score":2,"b_score":3,"a_evidence":"Alectinib's poor aqueous solubility (~0.03 mg/mL) creates hydrophobic microenvironments that precipitate proteins including C1q in SPR or pull-down assays","b_evidence":"Evidence Supporting the Hypothesis section cites prior work (identifiers: 29105784, 25645589, 28271790) linking hydrophobic aggregation to assay artifacts, establishing that the premise is grounded in documented literature.","disagreement":false},"statistical_reporting":{"score":1,"a_score":1,"b_score":1,"a_evidence":"No statistical tests, thresholds, corrections, or assumptions reported","b_evidence":"No statistical tests, thresholds, corrections, or assumptions are reported. Outcome measures are named but without quantitative decision criteria.","disagreement":false},"resource_identification":{"score":2,"a_score":1,"b_score":2,"a_evidence":"patient iPSC-derived neurons, primary microglia, or co-culture systems","b_evidence":"References 'patient iPSC-derived neurons, primary microglia, or co-culture systems' but provides no RRIDs, catalog numbers, vendor information, or specific reagent specifications.","disagreement":false}},"inter_rater_agreement":"0.64 (moderate-to-substantial)","dimensions_with_disagreement":[]},"_schema_version":1,"scored_entity_id":"h-df000ab0","scored_entity_type":"hypothesis","scored_entity_title":"Alectinib's Putative C1q Binding Derives from Hydrophobic Aggregation Rather Than Direct Protein-Protein Interaction"},"created_at":"2026-04-26T22:39:06.769444-07:00","updated_at":"2026-04-26T22:39:06.769446-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-26T22:39:06.769444-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"595d89a4-76a5-45e1-95b4-0f194f6650d1","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"rigor_score_card"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"rsc-h-df000ab0-c93726d2","is_canonical":true,"supersede_chain":["rsc-h-df000ab0-c93726d2"]}