{"artifact":{"id":"rsc-h-fa52cd0645-cf3a48b4","artifact_type":"rigor_score_card","entity_ids":null,"title":"Rigor Score Card: LncRNA-HDAC1 Complex Formation Locks Microglia in Primed State","quality_score":0.25,"created_by":"rigor_score_card","provenance_chain":"[{\"artifact_id\": \"h-fa52cd0645\", \"relation\": \"scores\"}]","content_hash":null,"metadata":{"dimensions":["scientific_premise","study_design","blinding","power_analysis","resource_identification","statistical_reporting","data_availability","sabv"],"eval_a_raw":{"scores":{"sabv":{"score":1,"evidence":"Perinatal immune activation induces a long non-coding RNA (e.g., Mirt2 or Neat1)","location":"Source hypothesis text, opening clause"},"blinding":{"score":1,"evidence":"maintaining chronic chromatin accessibility at inflammatory genes","location":"Source hypothesis text, final clause"},"study_design":{"score":1,"evidence":"Perinatal immune activation induces a long non-coding RNA (e.g., Mirt2 or Neat1) that sequesters HDAC1 into a complex with RelA","location":"Source hypothesis text, entire statement"},"power_analysis":{"score":1,"evidence":"preventing HDAC1-mediated deacetylation of NF-κB target promoters","location":"Source hypothesis text, mechanistic clause"},"data_availability":{"score":1,"evidence":"Perinatal immune activation induces a long non-coding RNA (e.g., Mirt2 or Neat1) that sequesters HDAC1 into a complex with RelA","location":"Source hypothesis text, entire statement"},"scientific_premise":{"score":2,"evidence":"Perinatal immune activation induces a long non-coding RNA (e.g., Mirt2 or Neat1)","location":"Source hypothesis text, sentence 1"},"statistical_reporting":{"score":1,"evidence":"maintaining chronic chromatin accessibility at inflammatory genes","location":"Source hypothesis text, outcome statement"},"resource_identification":{"score":1,"evidence":"long non-coding RNA (e.g., Mirt2 or Neat1) that sequesters HDAC1 into a complex with RelA","location":"Source hypothesis text, parenthetical and protein references"}},"overall_summary":"This source text is a mechanistic hypothesis rather than a study report, and scores reflect major deficiencies across all 8 dimensions of biomedical rigor due to the absence of empirical methodology, statistical planning, resource identifiers, or consideration of biological variables.","weakest_dimension":"study_design","strongest_dimension":"scientific_premise"},"eval_b_raw":{"scores":{"sabv":{"score":1,"evidence":"No mention of sex as a biological variable, sex-disaggregated analysis, or consideration of sex differences.","location":"Overall"},"blinding":{"score":1,"evidence":"No mention of blinding or assessor independence in this hypothesis statement.","location":"Overall"},"study_design":{"score":1,"evidence":"This is a mechanistic hypothesis statement describing a proposed biological process rather than reporting completed experimental work. No study design is described.","location":"Overall"},"power_analysis":{"score":1,"evidence":"No power analysis or sample size justification is present in this hypothesis statement.","location":"Overall"},"data_availability":{"score":1,"evidence":"No mention of data sharing, code availability, or public repository access in this hypothesis statement.","location":"Overall"},"scientific_premise":{"score":2,"evidence":"Perinatal immune activation induces a long non-coding RNA (e.g., Mirt2 or Neat1)","location":"Sentence 1"},"statistical_reporting":{"score":1,"evidence":"No statistical methods, tests, thresholds, or correction procedures are described in this hypothesis statement.","location":"Overall"},"resource_identification":{"score":2,"evidence":"(e.g., Mirt2 or Neat1)","location":"Sentence 1"}},"overall_summary":"This source text is a mechanistic hypothesis rather than a completed study, rendering most methodological dimensions inapplicable. While specific lncRNA examples (Mirt2, Neat1) and a defined molecular mechanism provide some grounding, the hypothesis lacks citations, empirical methods, statistical reporting, or resource identifiers—common limitations for pre-publication proposals that would be expected to be resolved before formal submission.","weakest_dimension":"study_design","strongest_dimension":"scientific_premise"},"provider_a":"minimax","provider_b":"glm","reconciled":{"reconciler_notes":"Both evaluators reached substantial consensus on this mechanistic hypothesis text, which lacks empirical methodology. The only difference (resource_identification: A=1, B=2) resulted from Evaluator A citing a longer textual span that included methodological context, while Evaluator B focused on the specific lncRNA examples. Per rule, |1-2|=1, so averaging yields score 2. All other 7 dimensions showed direct agreement. Cohen's Kappa not computed due to insufficient sample size (n=8) for stable estimation—full agreement at this scale could occur by chance. Strongest dimension: scientific_premise (score 2). Weakest dimensions: study_design, blinding, power_analysis, statistical_reporting, data_availability, sabv (all score 1).","overall_agreement":"high","reconciled_scores":{"sabv":{"score":1,"a_score":1,"b_score":1,"a_evidence":"Perinatal immune activation induces a long non-coding RNA (e.g., Mirt2 or Neat1)","b_evidence":"No mention of sex as a biological variable, sex-disaggregated analysis, or consideration of sex differences.","disagreement":false},"blinding":{"score":1,"a_score":1,"b_score":1,"a_evidence":"maintaining chronic chromatin accessibility at inflammatory genes","b_evidence":"No mention of blinding or assessor independence in this hypothesis statement.","disagreement":false},"study_design":{"score":1,"a_score":1,"b_score":1,"a_evidence":"Perinatal immune activation induces a long non-coding RNA (e.g., Mirt2 or Neat1) that sequesters HDAC1 into a complex with RelA","b_evidence":"This is a mechanistic hypothesis statement describing a proposed biological process rather than reporting completed experimental work. 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