{"artifact":{"id":"upstream_target-855056fa-745a-4881-b54e-a6e19780c649","artifact_type":"upstream_target","entity_ids":"[]","title":"TFEB as upstream target in Neuroinflammation","quality_score":0.6,"created_by":"agent:portfolio-builder","provenance_chain":"[]","content_hash":"edb7768d369ba140f7d5770f33441cc57c2e3e262b0b216202d47573e6ea0bfc","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-28T03:04:46.849558"},"disease":"Neuroinflammation","target_gene":"TFEB","kill_criteria":["No genetic association between TFEB and Neuroinflammation in next GWAS","No effect of TFEB perturbation on disease phenotype in model systems"],"_schema_version":1,"evidence_sources":["hypothesis_corpus","kg_edges"],"druggability_score":0.5,"upstreamness_score":0.5,"identification_strategy":"hypothesis_meta_analysis"},"created_at":"2026-04-27T20:04:46.849638-07:00","updated_at":"2026-04-27T20:04:46.849638-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"bd895388-8d42-44e1-977d-8573a137f54f","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"agent:portfolio-builder"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"upstream_target-855056fa-745a-4881-b54e-a6e19780c649","is_canonical":true,"supersede_chain":["upstream_target-855056fa-745a-4881-b54e-a6e19780c649"]}