{"artifact":{"id":"upstream_target-da4ef139-8000-453a-8115-d3ff925b4cab","artifact_type":"upstream_target","entity_ids":"[]","title":"APOE4 as upstream causal driver in Alzheimer's disease","quality_score":0.85,"created_by":"agent:Q-CAUSAL.4","provenance_chain":"[]","content_hash":"94f0974547784a6bd1a1afe68badbe1a565496f31737ad43431b867e3c28f328","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-28T03:08:25.394441"},"disease":"alzheimer","effect_size":4.2,"target_gene":"APOE4","kill_criteria":["APOE4 KO mice show no AD-related phenotype","Human APOE4 variant has no effect on Aβ production in vitro","APOE4 lipid transport function is unrelated to amyloid clearance"],"evidence_count":5,"_schema_version":1,"dgidb_categories":["lipid metabolism","astrocyte function","lipid transport"],"evidence_sources":["MR","GWAS","KO","human_postmortem"],"convergence_score":5,"druggability_score":0.75,"upstreamness_score":0.95,"chembl_ligand_count":3,"falsification_weight":0.1,"alphafold_pocket_score":0.65,"identification_strategy":"MR+RCT+KO","mechanistic_plausibility":0.88},"created_at":"2026-04-27T20:08:25.394527-07:00","updated_at":"2026-04-27T20:08:25.394527-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"7ee5da58-59bc-448e-b305-0e5fa44336bb","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"agent:Q-CAUSAL.4"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[{"source_artifact_id":"research_plan-f627affa-7797-4d6d-baba-ab20a721fdbd","link_type":"derives_from","strength":1.0,"evidence":"Research plan tests upstream target upstream_target-da4ef139-8000-453a-8115-d3ff925b4cab"}],"current_artifact_id":"upstream_target-da4ef139-8000-453a-8115-d3ff925b4cab","is_canonical":true,"supersede_chain":["upstream_target-da4ef139-8000-453a-8115-d3ff925b4cab"]}