{"artifact":{"id":"wiki-APOE","artifact_type":"wiki_page","entity_ids":"[\"APOE\"]","title":"APOE","quality_score":0.7,"created_by":"import","provenance_chain":null,"content_hash":"1d2fa3ab5b185e70bb4361c7e68ad248170c5666b3fccf7fc12a3dc55b10b0f3","metadata":{"summary":"Apolipoprotein E (APOE) is a lipid transport protein with three major isoforms (ε2, ε3, ε4). APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease, impacting amyloid clearance, tau pathology, neuroinflammation, and blood-brain barrier integrity. APOE2 is protective.","archived_at":"2026-05-13 16:31:36.170273-07","entity_type":"gene","neurowiki_url":"https://neurowiki.xyz/apoe","_schema_version":1,"archived_reason":"wiki_page_missing"},"created_at":"2026-04-02T06:44:06-07:00","updated_at":"2026-04-02T12:45:32-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"archived","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-05-13T16:31:36.170273-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"8b4f6d16-4298-49e2-9384-6a70c20f8498","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"import"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"hypothesis-h-b948c32c","link_type":"mentions","strength":0.85,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-637a53c9","link_type":"mentions","strength":0.6,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.9,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.9,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.9,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.9,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-9a108e26","link_type":"mentions","strength":0.6,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.9,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"mentions","strength":0.9,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-51e7234f","link_type":"mentions","strength":0.6,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-5d943bfc","link_type":"mentions","strength":0.6,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"mentions","strength":0.6,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"mentions","strength":0.9,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-58e655ee","link_type":"mentions","strength":0.6,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-15336069","link_type":"mentions","strength":0.9,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.75,"evidence":"Wiki page 'APOE' — entity mentioned in analysis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.75,"evidence":"Wiki page 'APOE' — entity mentioned in analysis"},{"target_artifact_id":"hypothesis-h-d2df6eaf","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-05b8894a","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-0758b337","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-5706bbd7","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-7d4a24d3","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-84808267","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-ec731b7a","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-3d993b5d","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-5e68b4ad","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-1e564178","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-807d7a82","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-3f02f222","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-470ff83e","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-97aa8486","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-ba3a948a","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-782b40b1","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-9e9fee95","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-82922df8","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-50a535f9","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-881362dc","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-fd52a7a0","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-de579caf","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-f9c6fa3f","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-de0d4364","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-9d29bfe5","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-2600483e","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-441b25ba","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-4dd0d19b","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-55ef81c5","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-fdaae8d9","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-bdbd2120","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-856feb98","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-addc0a61","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-8fe389e8","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-0e614ae4","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-seaad-56fa6428","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-seaad-v4-26ba859b","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-seaad-v4-29e81bbc","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-a87702b6","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-29ef94d5","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-e23f05fb","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-075f1f02","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-2f43b42f","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"hypothesis-h-3d545f4e","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'APOE' — entity matches hypothesis target"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.65,"evidence":"Wiki page 'APOE' — entity appears in KG edges for analysis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.65,"evidence":"Wiki page 'APOE' — entity appears in KG edges for analysis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"mentions","strength":0.65,"evidence":"Wiki page 'APOE' — entity appears in KG edges for analysis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.65,"evidence":"Wiki page 'APOE' — entity appears in KG edges for analysis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"mentions","strength":0.65,"evidence":"Wiki page 'APOE' — entity appears in KG edges for analysis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.65,"evidence":"Wiki page 'APOE' — entity appears in KG edges for analysis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-senescent-clearance-neuro","link_type":"mentions","strength":0.65,"evidence":"Wiki page 'APOE' — entity appears in KG edges for analysis"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"mentions","strength":0.65,"evidence":"Wiki page 'APOE' — entity appears in KG edges for analysis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v3-20260402063622","link_type":"mentions","strength":0.65,"evidence":"Wiki page 'APOE' — entity appears in KG edges for analysis"},{"target_artifact_id":"notebook-SEA-AD-gene-expression-analysis","link_type":"mentions","strength":0.7,"evidence":"Shared entity 'APOE'"},{"target_artifact_id":"notebook-sea_ad_2026_04_02","link_type":"mentions","strength":0.7,"evidence":"Shared entity 'APOE'"},{"target_artifact_id":"notebook-pathway_2026_04_02","link_type":"mentions","strength":0.7,"evidence":"Shared entity 'APOE'"},{"target_artifact_id":"notebook-aging-mouse-brain-2026-04-02","link_type":"mentions","strength":0.7,"evidence":"Shared entity 'APOE'"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"related","strength":0.6,"evidence":"Shared entity: apoe"},{"target_artifact_id":"hypothesis-h-15336069","link_type":"related","strength":0.6,"evidence":"Shared entity: apoe"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.6,"evidence":"Shared entity: apoe"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":0.6,"evidence":"Shared entity: apoe"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.6,"evidence":"Shared entity: apoe"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"related","strength":0.6,"evidence":"Shared entity: apoe"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.6,"evidence":"Shared entity: apoe"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"related","strength":0.6,"evidence":"Shared entity: apoe"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-amyloid-resilient-phenotype","link_type":"related","strength":0.65,"evidence":"Wiki entity matches experiment target gene: apoe"},{"target_artifact_id":"experiment-exp-wiki-experiments-sex-differences-alzheimers","link_type":"related","strength":0.65,"evidence":"Wiki entity matches experiment target gene: apoe"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-combination-therapy-trial","link_type":"related","strength":0.65,"evidence":"Wiki entity matches experiment target gene: apoe"},{"target_artifact_id":"experiment-exp-wiki-experiments-biomarker-guided-therapy-sequencing-ad","link_type":"related","strength":0.65,"evidence":"Wiki entity matches experiment target gene: apoe"},{"target_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-ad-detection","link_type":"related","strength":0.65,"evidence":"Wiki entity matches experiment target gene: apoe"},{"target_artifact_id":"experiment-exp-wiki-experiments-metal-ion-homeostasis-alzheimers","link_type":"related","strength":0.65,"evidence":"Wiki entity matches experiment target gene: apoe"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v4-20260402065846","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-amyloid-resilient-phenotype","link_type":"mentions","strength":0.85,"evidence":"Experiment targets gene APOE/BDNF/LDLR"},{"target_artifact_id":"experiment-exp-wiki-experiments-sex-differences-alzheimers","link_type":"mentions","strength":0.85,"evidence":"Experiment targets gene APOE/BDNF/LDLR"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-combination-therapy-trial","link_type":"mentions","strength":0.85,"evidence":"Experiment targets gene APOE/BDNF/LDLR"},{"target_artifact_id":"experiment-exp-wiki-experiments-biomarker-guided-therapy-sequencing-ad","link_type":"mentions","strength":0.85,"evidence":"Experiment targets gene APOE/BDNF/PPARGC1A"},{"target_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-ad-detection","link_type":"mentions","strength":0.85,"evidence":"Experiment targets gene ABCB1/APOE/CAV1"},{"target_artifact_id":"experiment-exp-wiki-experiments-metal-ion-homeostasis-alzheimers","link_type":"mentions","strength":0.85,"evidence":"Experiment targets gene ABCA1/APOE/CYP46A1"},{"target_artifact_id":"analysis-astrocyte-subtypes","link_type":"mentions","strength":0.5,"evidence":"Shared entity in analysis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"}],"incoming_links":[{"source_artifact_id":"experiment-exp-a6d16514-1a7a-45c3-8ca8-df341e213c0a","link_type":"related","strength":0.3333333333333333,"evidence":null},{"source_artifact_id":"experiment-exp-2267dce9-5cf9-4e2f-a543-e339e9156522","link_type":"related","strength":0.3333333333333333,"evidence":null},{"source_artifact_id":"experiment-exp-12e37301-cace-448f-a5e5-d03822faf9ef","link_type":"related","strength":0.3333333333333333,"evidence":null},{"source_artifact_id":"hypothesis-h-b948c32c","link_type":"related","strength":0.765,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"hypothesis-h-637a53c9","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":0.81,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"hypothesis-h-d0a564e8","link_type":"related","strength":0.81,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.81,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.81,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"hypothesis-h-9a108e26","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.81,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"related","strength":0.81,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"hypothesis-h-51e7234f","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"hypothesis-h-5d943bfc","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"hypothesis-h-180807e5","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"hypothesis-h-c9c79e3e","link_type":"related","strength":0.81,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"hypothesis-h-58e655ee","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"hypothesis-h-15336069","link_type":"related","strength":0.81,"evidence":"Reverse: Wiki page 'APOE' — entity matches hypothesis target"},{"source_artifact_id":"experiment-exp-wiki-experiments-ad-amyloid-resilient-phenotype","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Wiki entity matches experiment target gene: apoe"},{"source_artifact_id":"experiment-exp-wiki-experiments-sex-differences-alzheimers","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Wiki entity matches experiment target gene: apoe"},{"source_artifact_id":"experiment-exp-wiki-experiments-ad-combination-therapy-trial","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Wiki entity matches experiment target gene: apoe"},{"source_artifact_id":"experiment-exp-wiki-experiments-biomarker-guided-therapy-sequencing-ad","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Wiki entity matches experiment target gene: apoe"},{"source_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-ad-detection","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Wiki entity matches experiment target gene: apoe"},{"source_artifact_id":"experiment-exp-wiki-experiments-metal-ion-homeostasis-alzheimers","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Wiki entity matches experiment target gene: apoe"},{"source_artifact_id":"dataset-allen_brain-SEA-AD-MTG-10x","link_type":"mentions","strength":0.85,"evidence":"SEA-AD includes measurements relevant to this entity."},{"source_artifact_id":"hypothesis-h-44195347","link_type":"see_also","strength":0.8,"evidence":"Hypothesis targets gene APOE"},{"source_artifact_id":"hypothesis-h-d0a564e8","link_type":"see_also","strength":0.8,"evidence":"Hypothesis targets gene APOE"},{"source_artifact_id":"hypothesis-h-11795af0","link_type":"see_also","strength":0.8,"evidence":"Hypothesis targets gene APOE"},{"source_artifact_id":"hypothesis-h-99b4e2d2","link_type":"see_also","strength":0.8,"evidence":"Hypothesis targets gene APOE"},{"source_artifact_id":"hypothesis-h-a20e0cbb","link_type":"see_also","strength":0.8,"evidence":"Hypothesis targets gene APOE"},{"source_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"see_also","strength":0.8,"evidence":"Hypothesis targets gene APOE"},{"source_artifact_id":"hypothesis-h-c9c79e3e","link_type":"see_also","strength":0.8,"evidence":"Hypothesis targets gene APOE"},{"source_artifact_id":"hypothesis-h-15336069","link_type":"see_also","strength":0.8,"evidence":"Hypothesis targets gene APOE"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v3-20260402063622","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-senescent-clearance-neuro","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"tabular_dataset-e76c5510-0fe2-4852-823b-26563581abc9","link_type":"mentions","strength":0.5,"evidence":"Column 'gene_symbol' contains gene 'APOE'"},{"source_artifact_id":"figure-e920d0ebb59f","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"figure-575ef6190ee1","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"figure-cdd42d9d49df","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"figure-b81be778c47f","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"figure-5f7ff10a5459","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"figure-aecb5beefe65","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"figure-bd119008e4bc","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"figure-0dc52179e1d2","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"figure-593350d59b1a","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"figure-c5c69a188d65","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"analysis_proposal-63c0e114-91e3-4698-b87b-010fcb99f41b","link_type":"cites","strength":0.5,"evidence":"Proposal cites relevant entity wiki page"},{"source_artifact_id":"analysis_proposal-c1f406e9-085b-4514-8d84-f830930ce000","link_type":"cites","strength":0.5,"evidence":"Proposal cites relevant entity wiki page"},{"source_artifact_id":"analysis_proposal-aee99486-2375-4461-9c83-8c9c10ab2aa5","link_type":"cites","strength":0.5,"evidence":"Proposal cites relevant entity wiki page"},{"source_artifact_id":"figure-f3eeb2404e53","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"figure-7fae5699f763","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"figure-2318210191f5","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"figure-2e456aeb12db","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"figure-c693a09f89b9","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"},{"source_artifact_id":"figure-27f75eb846e8","link_type":"mentions","strength":0.8,"evidence":"entity_ids contains 'APOE', wiki artifact exists"}],"current_artifact_id":"wiki-APOE","is_canonical":true,"supersede_chain":["wiki-APOE"]}