{"artifact":{"id":"wiki-biomarkers-bdnf-brain-derived-neurotrophic-factor","artifact_type":"wiki_page","entity_ids":"[\"biomarkers-bdnf-brain-derived-neurotrophic-factor\"]","title":"BDNF - Neurotrophic Factor Biomarker","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"b0e25c0b988d8c121d02b7c16f38ec48a423561a4e9724d992b949f7354563e9","metadata":{"slug":"biomarkers-bdnf-brain-derived-neurotrophic-factor","kg_node_id":null,"entity_type":"biomarker","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-b3d25e66549c","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"biomarkers-bdnf-brain-derived-neurotrophic-factor"},"_schema_version":1},"created_at":"2026-04-02T07:20:04-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"35ba9e21-f445-4f28-abe7-192c377bf1b1","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-03a934e0-f1ad-47aa-9dcd-9cf748477080","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"hypothesis-h-e0183502","link_type":"mentions","strength":0.7,"evidence":"Gene match: BDNF"},{"target_artifact_id":"hypothesis-h-ee1df336","link_type":"mentions","strength":0.7,"evidence":"Gene match: BDNF"},{"target_artifact_id":"hypothesis-h-856feb98","link_type":"mentions","strength":0.7,"evidence":"Gene match: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-exercise-bdnf-mitophagy-parkinsons","link_type":"mentions","strength":0.8,"evidence":"Gene target: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-alpha-synuclein-spreading-neurodegeneration-pd","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-neural-stem-cell-therapy-alzheimers-disease","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"hypothesis-h-959a4677","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Brain'"},{"target_artifact_id":"hypothesis-h-f9c6fa3f","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Derived'"},{"target_artifact_id":"analysis-sda-2026-04-01-003","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'Brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'Brain'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'biomarkers'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"experiment-exp-wiki-experiments-alpha-synuclein-aggregation-triggers-sporadic-pd","link_type":"mentions","strength":0.5,"evidence":"Content: BDNF mentioned 64x in wiki/biomarkers-bdnf-brain-derived-neurotrophic-factor"},{"target_artifact_id":"experiment-exp-wiki-experiments-brain-connectivity-tacs-alzheimers","link_type":"mentions","strength":0.5,"evidence":"Content: BDNF mentioned 64x in wiki/biomarkers-bdnf-brain-derived-neurotrophic-factor"},{"target_artifact_id":"experiment-exp-wiki-experiments-microbiome-gut-barrier-als","link_type":"mentions","strength":0.5,"evidence":"Content: BDNF mentioned 64x in wiki/biomarkers-bdnf-brain-derived-neurotrophic-factor"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-amyloid-resilient-phenotype","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-cognitive-reserve-mechanisms-alzheimers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-gut-brain-axis-parkinsons-pathogenesis","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-sex-differences-alzheimers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-lifestyle-intervention-alzheimers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-combination-therapy-trial","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-biomarker-guided-therapy-sequencing-ad","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-viral-post-infectious-als-mechanism","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-alpha-synuclein-aggregation-triggers-sporadic-pd","link_type":"related","strength":0.7,"evidence":"Wiki page for BDNF related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-brain-connectivity-tacs-alzheimers","link_type":"related","strength":0.7,"evidence":"Wiki page for BDNF related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-microbiome-gut-barrier-als","link_type":"related","strength":0.7,"evidence":"Wiki page for BDNF related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-amyloid-resilient-phenotype","link_type":"related","strength":0.7,"evidence":"Wiki page for BDNF related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-cognitive-reserve-mechanisms-alzheimers","link_type":"related","strength":0.7,"evidence":"Wiki page for BDNF related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-exercise-bdnf-mitophagy-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for BDNF related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-gut-brain-axis-parkinsons-pathogenesis","link_type":"related","strength":0.7,"evidence":"Wiki page for BDNF related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-sex-differences-alzheimers","link_type":"related","strength":0.7,"evidence":"Wiki page for BDNF related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-lifestyle-intervention-alzheimers","link_type":"related","strength":0.7,"evidence":"Wiki page for BDNF related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-combination-therapy-trial","link_type":"related","strength":0.7,"evidence":"Wiki page for BDNF related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-macroautophagy-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for MA related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-biomarker-guided-therapy-sequencing-ad","link_type":"related","strength":0.7,"evidence":"Wiki page for BDNF related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-viral-post-infectious-als-mechanism","link_type":"related","strength":0.7,"evidence":"Wiki page for BDNF related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for CT related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-29ef94d5","link_type":"related","strength":0.7,"evidence":"Gene BDNF from multi-target hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"related","strength":0.5599999999999999,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-b3d6ecc2","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: degradation"},{"target_artifact_id":"hypothesis-h-8ef34c4c","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: degradation"},{"target_artifact_id":"hypothesis-h-8986b8af","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: degradation"},{"target_artifact_id":"hypothesis-h-0791836f","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: degradation"},{"target_artifact_id":"hypothesis-h-1acdd55e","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: plasticity"},{"target_artifact_id":"hypothesis-h-513a633f","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: plasticity"},{"target_artifact_id":"hypothesis-h-8d270062","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: plasticity"},{"target_artifact_id":"hypothesis-h-fdaae8d9","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: plasticity"},{"target_artifact_id":"hypothesis-h-seaad-5b3cb8ea","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Synaptic Pruning"},{"target_artifact_id":"hypothesis-h-29ef94d5","link_type":"mentions","strength":0.85,"evidence":"Gene target: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-chaperone-mediated-autophagy-parkinsons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-epigenetic-dysregulation-hd","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-epigenetic-regulation-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"experiment-exp-wiki-experiments-levodopa-induced-dyskinesia-mechanism","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"target_artifact_id":"wiki-proteins-creb-protein","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-hypotheses-exercise-bdnf-mitochondrial-resilience-parkinsons","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-cell-types-microglia-neurodegeneration-alzheimer","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-ideas-synapse-resilience-bdnf-glymphatic","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-cell-types-cerebellar-molecular-layer-interneurons-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-cell-types-microglia-alzheimer-disease-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-cell-types-bdnf-neurons","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-proteins-bdnf","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-hypotheses-exercise-bdnf-axis-parkinsons","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-therapeutics-bdnf-therapy","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-cell-types-brain-derived-neurotrophic-factor-neurons","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-proteins-bdnf-protein","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-genes-bdnf","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-investment-bdnf-therapy","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-experiments-exercise-bdnf-mitophagy-parkinsons","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-events-aaic-2026-cellular-pathophysiology-alzheimers","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-therapeutics-epigenetic-therapies-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-bdnf-signaling-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-therapeutics-mitochondrial-biogenesis-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-therapeutics-cellular-reprogramming","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-therapeutics-synaptic-protective-therapies-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-genes","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-bdnf-neurotrophin-signaling-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-bdnf-signaling-pathway","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-therapeutics-synaptic-stabilizers","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-osk-reprogramming-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-synaptic-plasticity-deficits","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-diseases-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-cellular-reprogramming-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-bdnf-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-therapeutics-epigenetic-reprogramming","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-29ef94d5","link_type":"related","strength":0.63,"evidence":"Reverse: Gene BDNF from multi-target hypothesis"},{"source_artifact_id":"experiment-exp-wiki-experiments-chaperone-mediated-autophagy-parkinsons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"source_artifact_id":"experiment-exp-wiki-experiments-epigenetic-dysregulation-hd","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"source_artifact_id":"experiment-exp-wiki-experiments-epigenetic-regulation-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"source_artifact_id":"experiment-exp-wiki-experiments-levodopa-induced-dyskinesia-mechanism","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"source_artifact_id":"experiment-exp-03a934e0-f1ad-47aa-9dcd-9cf748477080","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"source_artifact_id":"hypothesis-h-856feb98","link_type":"mentions","strength":0.8,"evidence":"Hypothesis involves entity 'BDNF' with wiki page"},{"source_artifact_id":"hypothesis-h-e0183502","link_type":"related","strength":0.63,"evidence":"Reverse: Gene match: BDNF"},{"source_artifact_id":"hypothesis-h-ee1df336","link_type":"related","strength":0.63,"evidence":"Reverse: Gene match: BDNF"},{"source_artifact_id":"hypothesis-h-856feb98","link_type":"related","strength":0.63,"evidence":"Reverse: Gene match: BDNF"},{"source_artifact_id":"experiment-exp-wiki-experiments-exercise-bdnf-mitophagy-parkinsons","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: BDNF"},{"source_artifact_id":"experiment-exp-wiki-experiments-alpha-synuclein-spreading-neurodegeneration-pd","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"source_artifact_id":"experiment-exp-wiki-experiments-neural-stem-cell-therapy-alzheimers-disease","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"source_artifact_id":"experiment-exp-wiki-experiments-alpha-synuclein-aggregation-triggers-sporadic-pd","link_type":"related","strength":0.7,"evidence":"Experiment targets BDNF described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-brain-connectivity-tacs-alzheimers","link_type":"related","strength":0.7,"evidence":"Experiment targets BDNF described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-microbiome-gut-barrier-als","link_type":"related","strength":0.7,"evidence":"Experiment targets BDNF described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-ad-amyloid-resilient-phenotype","link_type":"related","strength":0.7,"evidence":"Experiment targets BDNF described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-cognitive-reserve-mechanisms-alzheimers","link_type":"related","strength":0.7,"evidence":"Experiment targets BDNF described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-gut-brain-axis-parkinsons-pathogenesis","link_type":"related","strength":0.7,"evidence":"Experiment targets BDNF described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-sex-differences-alzheimers","link_type":"related","strength":0.7,"evidence":"Experiment targets BDNF described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-lifestyle-intervention-alzheimers","link_type":"related","strength":0.7,"evidence":"Experiment targets BDNF described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-ad-combination-therapy-trial","link_type":"related","strength":0.7,"evidence":"Experiment targets BDNF described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-macroautophagy-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets MA described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-biomarker-guided-therapy-sequencing-ad","link_type":"related","strength":0.7,"evidence":"Experiment targets BDNF described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-viral-post-infectious-als-mechanism","link_type":"related","strength":0.7,"evidence":"Experiment targets BDNF described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets CT described in wiki"},{"source_artifact_id":"hypothesis-h-959a4677","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-f9c6fa3f","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-003","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"wiki-proteins-creb-protein","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-hypotheses-exercise-bdnf-mitochondrial-resilience-parkinsons","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-cell-types-microglia-neurodegeneration-alzheimer","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-ideas-synapse-resilience-bdnf-glymphatic","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-cell-types-cerebellar-molecular-layer-interneurons-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-cell-types-microglia-alzheimer-disease-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-cell-types-bdnf-neurons","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-proteins-bdnf","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-hypotheses-exercise-bdnf-axis-parkinsons","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-therapeutics-bdnf-therapy","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-cell-types-brain-derived-neurotrophic-factor-neurons","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-proteins-bdnf-protein","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-genes-bdnf","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-investment-bdnf-therapy","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-experiments-exercise-bdnf-mitophagy-parkinsons","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-events-aaic-2026-cellular-pathophysiology-alzheimers","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-therapeutics-epigenetic-therapies-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-bdnf-signaling-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-therapeutics-mitochondrial-biogenesis-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-therapeutics-cellular-reprogramming","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-therapeutics-synaptic-protective-therapies-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-genes","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-bdnf-neurotrophin-signaling-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-bdnf-signaling-pathway","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-therapeutics-synaptic-stabilizers","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-osk-reprogramming-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-synaptic-plasticity-deficits","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-diseases-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-cellular-reprogramming-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-bdnf-neurodegeneration","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-therapeutics-epigenetic-reprogramming","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"open_question-biomarkers-bdnf-brain-derived-neurotrophic-factor-19fbfed0","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-biomarkers-bdnf-brain-derived-neurotrophic-factor-83d5e8e2","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-biomarkers-bdnf-brain-derived-neurotrophic-factor-b1aca42d","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-biomarkers-bdnf-brain-derived-neurotrophic-factor-9e2d9cb2","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-biomarkers-bdnf-brain-derived-neurotrophic-factor-8fc40450","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"}],"current_artifact_id":"wiki-biomarkers-bdnf-brain-derived-neurotrophic-factor","is_canonical":true,"supersede_chain":["wiki-biomarkers-bdnf-brain-derived-neurotrophic-factor"]}