{"artifact":{"id":"wiki-biomarkers-fractalkine-cx3cl1","artifact_type":"wiki_page","entity_ids":"[\"biomarkers-fractalkine-cx3cl1\"]","title":"Fractalkine (CX3CL1) - Neuroinflammation Biomarker","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"4d73961a4846cbf88ae865705c0b9eba31c6f23449cb3b6f5b8870f83662ca55","metadata":{"slug":"biomarkers-fractalkine-cx3cl1","kg_node_id":null,"entity_type":"biomarker","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-f7fb8b6ab132","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"biomarkers-fractalkine-cx3cl1"},"_schema_version":1},"created_at":"2026-04-02T07:20:04-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"36ea1658-f95c-4f7d-99f4-e4ba33dcc681","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"analysis-SDA-2026-04-04-gap-20260404-microglial-priming-early-ad","link_type":"related","strength":0.7,"evidence":"KG edge: h-494861d2 --[targets]--> CX3CL1"},{"target_artifact_id":"hypothesis-h-ba3a948a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Fractalkine'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'neuroinflammation'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'biomarkers'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'neuroinflammation'"},{"target_artifact_id":"hypothesis-h-782b40b1","link_type":"mentions","strength":0.6,"evidence":"Content: CX3CR1 mentioned 43x in wiki/biomarkers-fractalkine-cx3cl1"},{"target_artifact_id":"experiment-exp-debate-385d65cb42cb","link_type":"mentions","strength":0.5,"evidence":"Content: CX3CR1 mentioned 43x in wiki/biomarkers-fractalkine-cx3cl1"},{"target_artifact_id":"experiment-exp-wiki-experiments-macroautophagy-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for MA related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-ftd-microglia-role-protective-destructive","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about Neuroinflammation"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for CT related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-microglial-immune-hd","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about Neuroinflammation"},{"target_artifact_id":"experiment-exp-debate-36966e7145ad","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about Neuroinflammation"},{"target_artifact_id":"experiment-exp-debate-3d21c70cae2f","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about Neuroinflammation"},{"target_artifact_id":"experiment-exp-debate-ee3d58bfb795","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about Neuroinflammation"},{"target_artifact_id":"experiment-exp-debate-0303c1c48688","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about Neuroinflammation"},{"target_artifact_id":"experiment-exp-debate-385d65cb42cb","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about Neuroinflammation"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TREM2'"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TREM2'"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TREM2'"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TREM2'"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TREM2'"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TREM2'"},{"target_artifact_id":"hypothesis-h-ba3a948a","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-c8ccbee8","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: glymphatic clearance"},{"target_artifact_id":"hypothesis-h-62e56eb9","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: glymphatic clearance"},{"target_artifact_id":"hypothesis-h-35f04e1b","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Vascular"},{"target_artifact_id":"hypothesis-h-807d7a82","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: glymphatic clearance"},{"target_artifact_id":"hypothesis-h-1acdd55e","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Synaptic function"},{"target_artifact_id":"hypothesis-h-3f02f222","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Microglial activation"},{"target_artifact_id":"hypothesis-h-470ff83e","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Microglial activation"},{"target_artifact_id":"hypothesis-h-83efeed6","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: glymphatic clearance"},{"target_artifact_id":"hypothesis-h-38292315","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Microglial activation"},{"target_artifact_id":"hypothesis-h-513a633f","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Synaptic function"},{"target_artifact_id":"hypothesis-h-9e9fee95","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: glymphatic clearance"},{"target_artifact_id":"hypothesis-h-fb56c8a0","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Vascular"},{"target_artifact_id":"hypothesis-h-de579caf","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: glymphatic clearance"},{"target_artifact_id":"hypothesis-h-8597755b","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Microglial activation"},{"target_artifact_id":"hypothesis-h-8d270062","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Synaptic function"},{"target_artifact_id":"hypothesis-h-fdaae8d9","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Synaptic function"},{"target_artifact_id":"hypothesis-h-seaad-7f15df4c","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Synaptic Function"},{"target_artifact_id":"hypothesis-h-seaad-5b3cb8ea","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Synaptic Pruning"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.4,"evidence":"{\"via\": \"hypothesis_parent\"}"}],"incoming_links":[{"source_artifact_id":"experiment-exp-wiki-experiments-ftd-microglia-role-protective-destructive","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about Neuroinflammation"},{"source_artifact_id":"experiment-exp-wiki-experiments-microglial-immune-hd","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about Neuroinflammation"},{"source_artifact_id":"experiment-exp-debate-36966e7145ad","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about Neuroinflammation"},{"source_artifact_id":"experiment-exp-debate-3d21c70cae2f","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about Neuroinflammation"},{"source_artifact_id":"experiment-exp-debate-ee3d58bfb795","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about Neuroinflammation"},{"source_artifact_id":"experiment-exp-debate-0303c1c48688","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about Neuroinflammation"},{"source_artifact_id":"experiment-exp-debate-385d65cb42cb","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about Neuroinflammation"},{"source_artifact_id":"analysis-SDA-2026-04-04-gap-20260404-microglial-priming-early-ad","link_type":"related","strength":0.63,"evidence":"Reverse: KG edge: h-494861d2 --[targets]--> CX3CL1"},{"source_artifact_id":"hypothesis-h-782b40b1","link_type":"related","strength":0.54,"evidence":"Reverse: Content: CX3CR1 mentioned 43x in wiki/biomarkers-fractalkine-cx3cl1"},{"source_artifact_id":"experiment-exp-wiki-experiments-macroautophagy-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets MA described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets CT described in wiki"},{"source_artifact_id":"hypothesis-h-ba3a948a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"open_question-biomarkers-fractalkine-cx3cl1-ce420640","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-biomarkers-fractalkine-cx3cl1-46c9c115","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-biomarkers-fractalkine-cx3cl1-af3cbb7f","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-biomarkers-fractalkine-cx3cl1-adb20a00","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-biomarkers-fractalkine-cx3cl1-c2502164","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"}],"current_artifact_id":"wiki-biomarkers-fractalkine-cx3cl1","is_canonical":true,"supersede_chain":["wiki-biomarkers-fractalkine-cx3cl1"]}