{"artifact":{"id":"wiki-clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597","artifact_type":"wiki_page","entity_ids":"[\"clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597\"]","title":"dimethyl-fumarate-nrf2-ad-nct06850597","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"c845d30e6dbc09e11abd55c6ff30791ebd48102cbaad1dcbeaa2825891478daf","metadata":{"slug":"clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597","kg_node_id":null,"entity_type":"clinical_trial","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-01ee9debb8fa","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597"},"_schema_version":1},"created_at":"2026-04-02T07:19:04-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"c5df63dd-5243-43be-bffa-cc536e0fecea","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-46757fd6-b353-4551-b105-757ecff66ef9","link_type":"mentions","strength":0.5,"evidence":"Content: NRF2 mentioned 4x in wiki/clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597"},{"target_artifact_id":"experiment-exp-82df3491-a40f-4136-a61e-e8b6017cc9a7","link_type":"mentions","strength":0.5,"evidence":"Content: NRF2 mentioned 4x in wiki/clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597"},{"target_artifact_id":"experiment-exp-25159d1d-2d48-4bb0-bfb1-c59b93dd4dbc","link_type":"mentions","strength":0.5,"evidence":"Content: NRF2 mentioned 4x in wiki/clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597"},{"target_artifact_id":"experiment-exp-8b61762b-2663-4111-9e71-d728137b316c","link_type":"mentions","strength":0.5,"evidence":"Content: NFE2L2 mentioned 4x in wiki/clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597"},{"target_artifact_id":"experiment-exp-b92b3e79-53a0-47b9-a559-6a9a5a995c13","link_type":"mentions","strength":0.5,"evidence":"Content: NFE2L2 mentioned 4x in wiki/clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597"},{"target_artifact_id":"experiment-exp-c98631a3-a95e-4621-a68f-9cf145b22b97","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: NLRP3 mentioned 2x in wiki/clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597"},{"target_artifact_id":"experiment-exp-9d2d59a7-8bc0-4399-aab0-2538f3a07b6f","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: NLRP3 mentioned 2x in wiki/clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions experiment exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons: ...eutics](/experiment/exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons)\n- [Neural Stem Cel..."},{"target_artifact_id":"experiment-exp-wiki-experiments-macroautophagy-dysfunction-parkinsons","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions experiment exp-wiki-experiments-macroautophagy-dysfunction-parkinsons: ...Design](/experiment/exp-wiki-experiments-macroautophagy-dysfunction-parkinsons)\n- [Cytochrome Ther..."},{"target_artifact_id":"hypothesis-h-e7e1f943","link_type":"mentions","strength":0.5,"evidence":"Content: NLRP3 mentioned 2x in wiki/clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597"},{"target_artifact_id":"experiment-exp-wiki-experiments-nlrp3-inflammasome-parkinsons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: NLRP3 mentioned 2x in wiki/clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597"},{"target_artifact_id":"experiment-exp-wiki-experiments-neural-stem-cell-therapy-alzheimers-disease","link_type":"mentions","strength":0.5,"evidence":"Content: ADAS mentioned 4x in wiki/clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.9,"evidence":"Wiki page mentions gene TH targeted by hypothesis"},{"target_artifact_id":"experiment-exp-wiki-experiments-macroautophagy-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for MA related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for CT related to experiment"},{"target_artifact_id":"hypothesis-h-82922df8","link_type":"mentions","strength":0.4,"evidence":"Pathway match: nrf2"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-76888762","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: PGC-1α"},{"target_artifact_id":"hypothesis-h-b0cda336","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: PGC-1α"},{"target_artifact_id":"analysis-astrocyte-subtypes","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-20260401-225155: ...kinson's](/analysis/SDA-2026-04-01-gap-20260401-225155)\n\n**Related Experim..."},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-macroautophagy-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets MA described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets CT described in wiki"},{"source_artifact_id":"hypothesis-h-e7e1f943","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597","is_canonical":true,"supersede_chain":["wiki-clinical-trials-dimethyl-fumarate-nrf2-ad-nct06850597"]}