{"artifact":{"id":"wiki-clinical-trials-gm-csf-sargramostim-ad-nct04902703","artifact_type":"wiki_page","entity_ids":"[\"clinical-trials-gm-csf-sargramostim-ad-nct04902703\"]","title":"GM-CSF Sargramostim Phase 2 (NCT04902703) - AD Immunotherapy","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"e9969a0be37e730dadd1b3277fd0f9c8d9e5205247f85ac2bd68c48fefd3c3fc","metadata":{"slug":"clinical-trials-gm-csf-sargramostim-ad-nct04902703","kg_node_id":null,"entity_type":"trial","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-b45f995a52a7","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"clinical-trials-gm-csf-sargramostim-ad-nct04902703"},"_schema_version":1},"created_at":"2026-04-02T07:19:04-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"684d2535-d67e-41df-bcac-4f6b4d9e30c0","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"mentions","strength":0.55,"evidence":"Content: TLR4 mentioned 3x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"experiment-exp-9cfbd488-b96c-499a-993c-fbf6c024fe90","link_type":"mentions","strength":0.5,"evidence":"Content: TLR4 mentioned 3x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"experiment-exp-546a7e07-4a45-4e78-b0f9-50f2f2fd7e05","link_type":"mentions","strength":0.5,"evidence":"Content: TLR4 mentioned 3x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"experiment-exp-ca7e1e3a-74a4-4039-adc3-b35982349661","link_type":"mentions","strength":0.5,"evidence":"Content: TLR4 mentioned 3x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"hypothesis-h-ec731b7a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Phase'"},{"target_artifact_id":"hypothesis-h-97aa8486","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Phase'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'phase'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'phase'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-ev-ad-biomarkers","link_type":"mentions","strength":0.6,"evidence":"Gene mention: CSF"},{"target_artifact_id":"hypothesis-h-856feb98","link_type":"mentions","strength":0.5,"evidence":"Content: BDNF mentioned 2x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"hypothesis-h-e0183502","link_type":"mentions","strength":0.5,"evidence":"Content: BDNF mentioned 2x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"hypothesis-h-ee1df336","link_type":"mentions","strength":0.5,"evidence":"Content: BDNF mentioned 2x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"experiment-exp-wiki-experiments-alpha-synuclein-aggregation-triggers-sporadic-pd","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: BDNF mentioned 2x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"experiment-exp-wiki-experiments-brain-connectivity-tacs-alzheimers","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: BDNF mentioned 2x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"experiment-exp-wiki-experiments-microbiome-gut-barrier-als","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: BDNF mentioned 2x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.6,"evidence":"Content: TREM2 mentioned 5x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.6,"evidence":"Content: TREM2 mentioned 5x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 5x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 5x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 5x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.9,"evidence":"Wiki page mentions gene TH targeted by hypothesis"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for CT related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"related","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"related","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-f3fb3b91","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TLR4"},{"target_artifact_id":"analysis-SDA-2026-04-04-gap-neuro-microglia-early-ad-20260404","link_type":"mentions","strength":0.6,"evidence":"Gene mention: CSF"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"}],"incoming_links":[{"source_artifact_id":"analysis-SDA-2026-04-04-gap-neuro-microglia-early-ad-20260404","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: CSF"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-ev-ad-biomarkers","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: CSF"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.54,"evidence":"Reverse: Content: TREM2 mentioned 5x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.54,"evidence":"Reverse: Content: TREM2 mentioned 5x in wiki/clinical-trials-gm-csf-sargramostim-ad-nct04902703"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets CT described in wiki"},{"source_artifact_id":"hypothesis-h-ec731b7a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-97aa8486","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-856feb98","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-e0183502","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ee1df336","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"open_question-clinical-trials-gm-csf-sargramostim-ad-nct04902703-f7296d5d","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-clinical-trials-gm-csf-sargramostim-ad-nct04902703-24c5bcee","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-clinical-trials-gm-csf-sargramostim-ad-nct04902703-358899f5","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-clinical-trials-gm-csf-sargramostim-ad-nct04902703-18cd13c1","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"}],"current_artifact_id":"wiki-clinical-trials-gm-csf-sargramostim-ad-nct04902703","is_canonical":true,"supersede_chain":["wiki-clinical-trials-gm-csf-sargramostim-ad-nct04902703"]}