{"artifact":{"id":"wiki-convergence-synthesis-protein-aggregation-clearance","artifact_type":"wiki_page","entity_ids":"[\"convergence-synthesis-protein-aggregation-clearance\", \"h-d0a564e8\", \"h-seaad-v4-5a7a4079\", \"hyp-lyso-snca-548064db6357\", \"h-a9571dbb\", \"h-441b25ba\"]","title":"Composite Claim: Protein Aggregation Becomes Toxic Through Failed Clearance Interfaces","quality_score":0.82,"created_by":"codex:53","provenance_chain":"[{\"artifact_id\": \"hypothesis-h-d0a564e8\", \"relation\": \"synthesizes\"}, {\"artifact_id\": \"hypothesis-h-seaad-v4-5a7a4079\", \"relation\": \"synthesizes\"}, {\"artifact_id\": \"hypothesis-hyp-lyso-snca-548064db6357\", \"relation\": \"synthesizes\"}, {\"artifact_id\": \"hypothesis-h-a9571dbb\", \"relation\": \"synthesizes\"}, {\"artifact_id\": \"hypothesis-h-441b25ba\", \"relation\": \"synthesizes\"}]","content_hash":"9ddf4312f17f24321a0ae74e63d5be3bdf91b2b39b776aa28ba8f1e706ece9c1","metadata":{"url":"/wiki/convergence-synthesis-protein-aggregation-clearance","task_id":"b010bbfa-414f-4bda-a1e6-ad769510df07","wiki_slug":"convergence-synthesis-protein-aggregation-clearance","origin_type":"v1_polymorphic_backfill","generated_by":"backfill/convergence_synthesis_b010bbfa.py","source_table":"wiki_pages","wiki_page_id":"convergence-synthesis-protein-aggregation-clearance","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"convergence-synthesis-protein-aggregation-clearance"},"_schema_version":1,"source_hypotheses":["h-d0a564e8","h-seaad-v4-5a7a4079","hyp-lyso-snca-548064db6357","h-a9571dbb","h-441b25ba"],"source_hypothesis_count":5},"created_at":"2026-04-27T23:57:40.423858-07:00","updated_at":"2026-04-27T23:57:40.423858-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"listed","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":"/wiki/convergence-synthesis-protein-aggregation-clearance","lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"b994a9e7-de32-41cb-b879-2ccb0a6c0df4","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"codex:53"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.88,"evidence":"Convergence synthesis cites source hypothesis h-d0a564e8 [task:b010bbfa-414f-4bda-a1e6-ad769510df07]"},{"target_artifact_id":"hypothesis-h-seaad-v4-5a7a4079","link_type":"mentions","strength":0.88,"evidence":"Convergence synthesis cites source hypothesis h-seaad-v4-5a7a4079 [task:b010bbfa-414f-4bda-a1e6-ad769510df07]"},{"target_artifact_id":"hypothesis-hyp-lyso-snca-548064db6357","link_type":"mentions","strength":0.88,"evidence":"Convergence synthesis cites source hypothesis hyp-lyso-snca-548064db6357 [task:b010bbfa-414f-4bda-a1e6-ad769510df07]"},{"target_artifact_id":"hypothesis-h-a9571dbb","link_type":"mentions","strength":0.88,"evidence":"Convergence synthesis cites source hypothesis h-a9571dbb [task:b010bbfa-414f-4bda-a1e6-ad769510df07]"},{"target_artifact_id":"hypothesis-h-441b25ba","link_type":"mentions","strength":0.88,"evidence":"Convergence synthesis cites source hypothesis h-441b25ba [task:b010bbfa-414f-4bda-a1e6-ad769510df07]"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-d0a564e8","link_type":"supports","strength":0.88,"evidence":"Top-five source hypothesis supporting convergence synthesis convergence-synthesis-protein-aggregation-clearance [task:b010bbfa-414f-4bda-a1e6-ad769510df07]"},{"source_artifact_id":"hypothesis-h-seaad-v4-5a7a4079","link_type":"supports","strength":0.88,"evidence":"Top-five source hypothesis supporting convergence synthesis convergence-synthesis-protein-aggregation-clearance [task:b010bbfa-414f-4bda-a1e6-ad769510df07]"},{"source_artifact_id":"hypothesis-hyp-lyso-snca-548064db6357","link_type":"supports","strength":0.88,"evidence":"Top-five source hypothesis supporting convergence synthesis convergence-synthesis-protein-aggregation-clearance [task:b010bbfa-414f-4bda-a1e6-ad769510df07]"},{"source_artifact_id":"hypothesis-h-a9571dbb","link_type":"supports","strength":0.88,"evidence":"Top-five source hypothesis supporting convergence synthesis convergence-synthesis-protein-aggregation-clearance [task:b010bbfa-414f-4bda-a1e6-ad769510df07]"},{"source_artifact_id":"hypothesis-h-441b25ba","link_type":"supports","strength":0.88,"evidence":"Top-five source hypothesis supporting convergence synthesis convergence-synthesis-protein-aggregation-clearance [task:b010bbfa-414f-4bda-a1e6-ad769510df07]"}],"current_artifact_id":"wiki-convergence-synthesis-protein-aggregation-clearance","is_canonical":true,"supersede_chain":["wiki-convergence-synthesis-protein-aggregation-clearance"]}