{"artifact":{"id":"wiki-experiments-fxtas-penetrance-modifiers","artifact_type":"wiki_page","entity_ids":"[\"experiments-fxtas-penetrance-modifiers\"]","title":"FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutation Carriers Develop FXTAS","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"e8a4ac37b6bc66d2cb0c54fde60907618272c6c3bc204b74539b796b783958e5","metadata":{"slug":"experiments-fxtas-penetrance-modifiers","kg_node_id":null,"entity_type":"experiment","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-370fcbc96310","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"experiments-fxtas-penetrance-modifiers"},"_schema_version":1},"created_at":"2026-04-02T07:20:09-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"0864af03-da6d-4cb8-b343-5d626a6c3164","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-wiki-experiments-fxtas-penetrance-modifiers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: FXTAS"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'penetrance'"},{"target_artifact_id":"experiment-exp-wiki-experiments-non-motor-symptom-progression-pd","link_type":"related","strength":0.7,"evidence":"Wiki page for REM related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-fxtas-penetrance-modifiers","link_type":"related","strength":0.7,"evidence":"Wiki page for FXTAS related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-0758b337","link_type":"mentions","strength":0.55,"evidence":"Keyword 'PHENOTYPIC' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'PHENOTYPIC' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'PHENOTYPIC' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-881362dc","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-ac55ff26","link_type":"mentions","strength":0.55,"evidence":"Keyword 'PHENOTYPIC' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'PHENOTYPIC' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-5706bbd7","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-97aa8486","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-0f00fd75","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-c8ccbee8","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-addc0a61","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-ec731b7a","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-d2722680","link_type":"mentions","strength":0.55,"evidence":"Keyword 'PHENOTYPIC' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-seaad-56fa6428","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-69d383ea","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-2600483e","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-82922df8","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-bdbd2120","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-807d7a82","link_type":"mentions","strength":0.55,"evidence":"Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'CARRIERS' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-f9c6fa3f","link_type":"mentions","strength":0.55,"evidence":"Keyword 'PHENOTYPIC' from wiki title in hypothesis text"},{"target_artifact_id":"hypothesis-h-7e846ceb","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TARDBP"},{"target_artifact_id":"hypothesis-h-4fabd9ce","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TARDBP"},{"target_artifact_id":"hypothesis-h-eea667a9","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TARDBP"},{"target_artifact_id":"hypothesis-h-7693c291","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TARDBP"},{"target_artifact_id":"hypothesis-h-e5a1c16b","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TFEB"},{"target_artifact_id":"hypothesis-h-e3e8407c","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TFEB"},{"target_artifact_id":"hypothesis-h-8f285020","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene AGER"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.385,"evidence":"Via hypothesis: Keyword 'PHENOTYPIC' from wiki title in hypothesis text"}],"incoming_links":[{"source_artifact_id":"experiment-exp-wiki-experiments-fxtas-penetrance-modifiers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: FXTAS"},{"source_artifact_id":"experiment-exp-wiki-experiments-non-motor-symptom-progression-pd","link_type":"related","strength":0.7,"evidence":"Experiment targets REM described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"experiment-exp-wiki-experiments-fxtas-penetrance-modifiers","link_type":"derives_from","strength":0.95,"evidence":"backfill from wiki content"}],"current_artifact_id":"wiki-experiments-fxtas-penetrance-modifiers","is_canonical":true,"supersede_chain":["wiki-experiments-fxtas-penetrance-modifiers"]}