{"artifact":{"id":"wiki-experiments-trem2-agonist-efficacy","artifact_type":"wiki_page","entity_ids":"[\"experiments-trem2-agonist-efficacy\"]","title":"Microglial TREM2 Agonist In Vivo Efficacy","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"db53a6e349c5493831559dde2101ccac5c0cb7571939c3cab5b3c4376e059d9a","metadata":{"slug":"experiments-trem2-agonist-efficacy","kg_node_id":null,"entity_type":"experiment","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-4be05903a334","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"experiments-trem2-agonist-efficacy"},"_schema_version":1},"created_at":"2026-04-02T07:20:09-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"4f3773b0-fa8f-43fc-98b7-aecc62a3c1fb","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"analysis-SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-04-gap-neuroinflammation-microglial-20260404","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-11-gap-debate-20260410-111113-052488a8","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-11-gap-debate-20260410-112636-141592ba","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.7,"evidence":"Gene match: TREM2"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.7,"evidence":"Gene match: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"mentions","strength":0.6,"evidence":"Title match: Microglial TREM2 Agonist In Vivo Efficacy"},{"target_artifact_id":"hypothesis-h-5daecb6e","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Microglial'"},{"target_artifact_id":"hypothesis-h-470ff83e","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Microglial'"},{"target_artifact_id":"hypothesis-h-f99ce4ca","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Agonist'"},{"target_artifact_id":"hypothesis-h-38292315","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Microglial'"},{"target_artifact_id":"hypothesis-h-782b40b1","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Microglial'"},{"target_artifact_id":"analysis-sda-2026-04-01-001","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'TREM2'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'efficacy'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-microglial-subtypes-20260402004119","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'microglial'"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 22x in wiki/experiments-trem2-agonist-efficacy"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 22x in wiki/experiments-trem2-agonist-efficacy"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.3,"evidence":"Transitive: wiki→hypothesis→analysis"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.7,"evidence":"Gene match: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"related","strength":0.7,"evidence":"Wiki page for TREM2 related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-non-motor-symptom-progression-pd","link_type":"related","strength":0.7,"evidence":"Wiki page for REM related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for TREM2 related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"related","strength":0.7,"evidence":"Wiki page for TREM2 related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.6,"evidence":"Entity name match: TREM2"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"mentions","strength":0.6,"evidence":"Entity name match: TREM2"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"mentions","strength":0.6,"evidence":"Entity name match: TREM2"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"related","strength":0.7,"evidence":"Wiki title matches hypothesis target gene: trem2"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-04-gap-neuro-microglia-early-ad-20260404","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"wiki-biomarkers-strem2-soluble-trem2","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-biomarkers-strem2","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-al002-trem2-agonist-alzheimers","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-entities-trem2","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-trem2-als","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-trem2-gene-mechanism-therapy-chain","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-trem2-ftd","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-astrocyte-subtypes","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-61196ade","link_type":"related","strength":0.54,"evidence":"Reverse: Entity name match: TREM2"},{"source_artifact_id":"hypothesis-h-3460f820","link_type":"related","strength":0.54,"evidence":"Reverse: Entity name match: TREM2"},{"source_artifact_id":"hypothesis-h-180807e5","link_type":"related","strength":0.54,"evidence":"Reverse: Entity name match: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-04-gap-neuro-microglia-early-ad-20260404","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-04-gap-neuroinflammation-microglial-20260404","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-11-gap-debate-20260410-111113-052488a8","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-11-gap-debate-20260410-112636-141592ba","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.8,"evidence":"Hypothesis involves entity 'TREM2' with wiki page"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.8,"evidence":"Hypothesis involves entity 'TREM2' with wiki page"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.63,"evidence":"Reverse: Gene match: TREM2"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.63,"evidence":"Reverse: Gene match: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Microglial TREM2 Agonist In Vivo Efficacy"},{"source_artifact_id":"hypothesis-h-seaad-51323624","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TREM2 described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"related","strength":0.7,"evidence":"Experiment targets TREM2 described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-non-motor-symptom-progression-pd","link_type":"related","strength":0.7,"evidence":"Experiment targets REM described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets TREM2 described in wiki"},{"source_artifact_id":"hypothesis-h-5daecb6e","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-470ff83e","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-f99ce4ca","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-38292315","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-782b40b1","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-microglial-subtypes-20260402004119","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-001","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"derives_from","strength":0.95,"evidence":"backfill from wiki content"},{"source_artifact_id":"wiki-biomarkers-strem2-soluble-trem2","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-biomarkers-strem2","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-al002-trem2-agonist-alzheimers","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-entities-trem2","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-trem2-als","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-trem2-gene-mechanism-therapy-chain","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-trem2-ftd","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-astrocyte-subtypes","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"}],"current_artifact_id":"wiki-experiments-trem2-agonist-efficacy","is_canonical":true,"supersede_chain":["wiki-experiments-trem2-agonist-efficacy"]}