{"artifact":{"id":"wiki-genes-tp53","artifact_type":"wiki_page","entity_ids":"[\"TP53\"]","title":"TP53 Gene","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"92acfedc7a9238c35a0bf7d8f4cccf6e2bbd453068a9c581e393919fb2046cb5","metadata":{"slug":"genes-tp53","kg_node_id":"TP53","entity_type":"gene","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-9969b756b840","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"genes-tp53"},"_schema_version":1},"created_at":"2026-04-02T07:19:26-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"4d81fed0-844d-4a3b-a8f4-8d40ccb4ef89","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-e6cdf2ea-4518-4cb6-8a05-0fc98103555b","link_type":"mentions","strength":0.8,"evidence":"Gene target: TP53"},{"target_artifact_id":"experiment-exp-c79f2a42-f3dd-4b38-99f5-d17ee1a21462","link_type":"mentions","strength":0.8,"evidence":"Gene target: TP53"},{"target_artifact_id":"experiment-exp-291a1cad-3f58-40eb-95c1-042d21a8077b","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TP53"},{"target_artifact_id":"analysis-SDA-2026-04-04-gap-senescent-clearance-neuro","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: TP53"},{"target_artifact_id":"hypothesis-h-ac55ff26","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Gene'"},{"target_artifact_id":"hypothesis-h-2600483e","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Gene'"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'genes'"},{"target_artifact_id":"hypothesis-h-e6437136","link_type":"mentions","strength":0.5,"evidence":"Entity 'TP53' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'TP53'"},{"target_artifact_id":"hypothesis-h-d2722680","link_type":"mentions","strength":0.5,"evidence":"Entity 'TP53' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'TP53'"},{"target_artifact_id":"hypothesis-h-ae1b2beb","link_type":"mentions","strength":0.5,"evidence":"Entity 'TP53' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'TP53'"},{"target_artifact_id":"hypothesis-h-83efeed6","link_type":"mentions","strength":0.5,"evidence":"Entity 'TP53' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'TP53'"},{"target_artifact_id":"hypothesis-h-55ef81c5","link_type":"mentions","strength":0.5,"evidence":"Entity 'TP53' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'TP53'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-57862f8a","link_type":"mentions","strength":0.5,"evidence":"KG transitive via IDH2"},{"target_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"mentions","strength":0.5,"evidence":"KG transitive via HSPA1A"},{"target_artifact_id":"hypothesis-h-d7121bcc","link_type":"mentions","strength":0.5,"evidence":"KG transitive via TET2"},{"target_artifact_id":"hypothesis-h-a90e2e89","link_type":"mentions","strength":0.5,"evidence":"KG transitive via TET2"},{"target_artifact_id":"hypothesis-h-a1b56d74","link_type":"mentions","strength":0.5,"evidence":"KG transitive via HK2"},{"target_artifact_id":"hypothesis-h-38292315","link_type":"mentions","strength":0.5,"evidence":"KG transitive via HK2"},{"target_artifact_id":"hypothesis-h-5706bbd7","link_type":"mentions","strength":0.5,"evidence":"KG transitive via BMAL1"},{"target_artifact_id":"hypothesis-h-aa2d317c","link_type":"mentions","strength":0.5,"evidence":"KG transitive via TFR1"},{"target_artifact_id":"hypothesis-h-3d993b5d","link_type":"mentions","strength":0.5,"evidence":"KG transitive via PLIN2"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-5e68b4ad","link_type":"mentions","strength":0.5,"evidence":"KG transitive via STX17"},{"target_artifact_id":"hypothesis-h-3f02f222","link_type":"mentions","strength":0.5,"evidence":"KG transitive via BCL2L1"},{"target_artifact_id":"hypothesis-h-ecacd219","link_type":"mentions","strength":0.5,"evidence":"KG transitive via NPM1"},{"target_artifact_id":"hypothesis-h-881362dc","link_type":"mentions","strength":0.5,"evidence":"KG transitive via KDM6A"},{"target_artifact_id":"hypothesis-h-4dd0d19b","link_type":"mentions","strength":0.5,"evidence":"KG transitive via LRP1"},{"target_artifact_id":"hypothesis-h-0f00fd75","link_type":"mentions","strength":0.5,"evidence":"KG transitive via HSP90AA1"},{"target_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"mentions","strength":0.5,"evidence":"KG transitive via SIRT1"},{"target_artifact_id":"hypothesis-h-8fe389e8","link_type":"mentions","strength":0.5,"evidence":"KG transitive via HDAC"},{"target_artifact_id":"hypothesis-h-0e614ae4","link_type":"mentions","strength":0.5,"evidence":"KG transitive via SIRT3"},{"target_artifact_id":"hypothesis-h-seaad-v4-5a7a4079","link_type":"mentions","strength":0.5,"evidence":"KG transitive via SIRT3"},{"target_artifact_id":"wiki-genes-actb","link_type":"see_also","strength":0.6,"evidence":"KG edge: interacts_with"},{"target_artifact_id":"wiki-genes-acvr2a","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-institutions-amp-ad","link_type":"see_also","strength":0.6,"evidence":"KG edge: implicated_in"},{"target_artifact_id":"wiki-genes-ago2","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"target_artifact_id":"wiki-genes-abca1","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"target_artifact_id":"wiki-genes-acsl4","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-genes-aggf1","link_type":"see_also","strength":0.6,"evidence":"KG edge: stabilizes"},{"target_artifact_id":"wiki-mechanisms-aging-vs-neurodegeneration-comparison","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"target_artifact_id":"hypothesis-h-seaad-v4-26ba859b","link_type":"mentions","strength":0.5,"evidence":"Entity 'TP53' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v4-20260402065846","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'TP53'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-seaad-v4-26ba859b","link_type":"related","strength":0.55,"evidence":"Shared KG edge: ACSL4 → TP53"},{"target_artifact_id":"hypothesis-h-83efeed6","link_type":"related","strength":0.55,"evidence":"Shared KG edge: ALOX12 → TP53"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-76888762","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene PPARGC1A"},{"target_artifact_id":"hypothesis-h-856feb98","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene BDNF"},{"target_artifact_id":"hypothesis-h-51e7234f","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene MTOR"},{"target_artifact_id":"hypothesis-h-43f72e21","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: energy sensing"},{"target_artifact_id":"hypothesis-h-b0cda336","link_type":"mentions","strength":0.7,"evidence":"Wiki content mentions gene PPARGC1A"},{"target_artifact_id":"analysis-SDA-2026-04-04-gap-senescent-clearance-neuro","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: TP53"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-b0cda336","link_type":"related","strength":0.63,"evidence":"Reverse: Wiki content mentions gene PPARGC1A"},{"source_artifact_id":"experiment-exp-e6cdf2ea-4518-4cb6-8a05-0fc98103555b","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TP53"},{"source_artifact_id":"experiment-exp-c79f2a42-f3dd-4b38-99f5-d17ee1a21462","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TP53"},{"source_artifact_id":"experiment-exp-291a1cad-3f58-40eb-95c1-042d21a8077b","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TP53"},{"source_artifact_id":"experiment-exp-c79f2a42-f3dd-4b38-99f5-d17ee1a21462","link_type":"mentions","strength":0.5,"evidence":"Entity TP53 in experiment"},{"source_artifact_id":"experiment-exp-291a1cad-3f58-40eb-95c1-042d21a8077b","link_type":"mentions","strength":0.5,"evidence":"Entity TP53 in experiment"},{"source_artifact_id":"hypothesis-h-ac55ff26","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-2600483e","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-e6437136","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-d2722680","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ae1b2beb","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-83efeed6","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-55ef81c5","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"wiki-genes-plcg1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-xpo1","link_type":"see_also","strength":0.6,"evidence":"KG edge: reduces"},{"source_artifact_id":"wiki-genes-ebf3","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"source_artifact_id":"wiki-genes-fbp1","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"source_artifact_id":"wiki-genes-sox11","link_type":"see_also","strength":0.6,"evidence":"KG edge: therapeutic_target"},{"source_artifact_id":"wiki-genes-rac2","link_type":"see_also","strength":0.6,"evidence":"KG edge: interacts_with"},{"source_artifact_id":"wiki-genes-e2f4","link_type":"see_also","strength":0.6,"evidence":"KG edge: treats"},{"source_artifact_id":"wiki-genes-gfra1","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"source_artifact_id":"wiki-genes-impdh1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-rad23b","link_type":"see_also","strength":0.6,"evidence":"KG edge: binds"},{"source_artifact_id":"wiki-genes-nfkbie","link_type":"see_also","strength":0.6,"evidence":"KG edge: interacts_with"},{"source_artifact_id":"wiki-genes-il17a","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-genes-map2k2","link_type":"see_also","strength":0.6,"evidence":"KG edge: expressed_in"},{"source_artifact_id":"wiki-genes-ctsc","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-genes-kcnk5","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-genes-aggf1","link_type":"see_also","strength":0.6,"evidence":"KG edge: stabilizes"},{"source_artifact_id":"wiki-genes-tgfb3","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-genes-phf6","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-genes-rpl23","link_type":"see_also","strength":0.6,"evidence":"KG edge: causes"},{"source_artifact_id":"wiki-genes-kdm4a","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-genes-ube2i","link_type":"see_also","strength":0.6,"evidence":"KG edge: expressed_in"},{"source_artifact_id":"wiki-genes-ulk3","link_type":"see_also","strength":0.6,"evidence":"KG edge: therapeutic_target"},{"source_artifact_id":"wiki-genes-bicd2","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-genes-senp2","link_type":"see_also","strength":0.6,"evidence":"KG edge: expressed_in"},{"source_artifact_id":"wiki-genes-sust","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-cell-types-enteric-glia","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates_pathway_in"},{"source_artifact_id":"wiki-proteins-plcg1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-trex1","link_type":"see_also","strength":0.6,"evidence":"KG edge: inhibits"},{"source_artifact_id":"wiki-genes-trim24","link_type":"see_also","strength":0.6,"evidence":"KG edge: inhibits"},{"source_artifact_id":"wiki-cell-types-basal-radial-glia","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates_pathway_in"},{"source_artifact_id":"wiki-cell-types-neural-crest-derived-glia","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates_pathway_in"},{"source_artifact_id":"wiki-cell-types-bergmann-glia","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates_pathway_in"},{"source_artifact_id":"wiki-cell-types-ng2-glia","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates_pathway_in"},{"source_artifact_id":"wiki-cell-types-muller-glia","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates_pathway_in"},{"source_artifact_id":"wiki-cell-types-satellite-glia","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates_pathway_in"},{"source_artifact_id":"wiki-cell-types-radial-glia","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates_pathway_in"},{"source_artifact_id":"wiki-cell-types-outer-radial-glia","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates_pathway_in"},{"source_artifact_id":"wiki-cell-types-nigral-glia","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates_pathway_in"},{"source_artifact_id":"wiki-mechanisms-axonal-degeneration","link_type":"see_also","strength":0.6,"evidence":"KG edge: causes"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v4-20260402065846","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-genes-tp53","is_canonical":true,"supersede_chain":["wiki-genes-tp53"]}