{"artifact":{"id":"wiki-hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers","artifact_type":"wiki_page","entity_ids":"[\"hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers\"]","title":"Circadian-Glymphatic-Metabolic Coupling Failure Hypothesis in AD","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"24e18ea797add44542790b41b3a19e8bcfe8c7b15199292c7a14e791ef804fb9","metadata":{"slug":"hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers","kg_node_id":null,"entity_type":"hypothesis","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-9974bd1fee49","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},"_schema_version":1},"created_at":"2026-04-02T07:19:34-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"7e3283bd-b6ca-4121-bb34-eb481de36aa5","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-5372ff3e-edbb-4215-aa15-a06d501e46bd","link_type":"mentions","strength":0.5,"evidence":"Content: BMAL1 mentioned 12x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"target_artifact_id":"experiment-exp-545ecac0-8b8e-4dc1-b999-1118f810815a","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: GFAP mentioned 2x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"target_artifact_id":"experiment-exp-c8a2bc28-860e-480e-b967-24f9af1b0b0a","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PER2 mentioned 2x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"target_artifact_id":"hypothesis-h-57862f8a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Metabolic'"},{"target_artifact_id":"hypothesis-h-a1b56d74","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Metabolic'"},{"target_artifact_id":"hypothesis-h-5706bbd7","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Circadian'"},{"target_artifact_id":"hypothesis-h-7e0b5ade","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Circadian'"},{"target_artifact_id":"hypothesis-h-62e56eb9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Glymphatic'"},{"target_artifact_id":"hypothesis-h-3d993b5d","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Metabolic'"},{"target_artifact_id":"hypothesis-h-019ad538","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Circadian'"},{"target_artifact_id":"hypothesis-h-ae1b2beb","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Coupling'"},{"target_artifact_id":"hypothesis-h-b0cda336","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Metabolic'"},{"target_artifact_id":"hypothesis-h-0e0cc0c1","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Circadian'"},{"target_artifact_id":"hypothesis-h-83efeed6","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Circadian'"},{"target_artifact_id":"hypothesis-h-38292315","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Metabolic'"},{"target_artifact_id":"hypothesis-h-9e9fee95","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Circadian'"},{"target_artifact_id":"hypothesis-h-41bc2d38","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Metabolic'"},{"target_artifact_id":"hypothesis-h-de579caf","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Circadian'"},{"target_artifact_id":"hypothesis-h-b7898b79","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Circadian'"},{"target_artifact_id":"hypothesis-h-6b84d8e2","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Coupling'"},{"target_artifact_id":"analysis-sda-2026-04-01-001","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'failure'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-004","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'metabolic'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'glymphatic'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'circadian'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'metabolic'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'hypotheses'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'Alzheimers'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'hypotheses'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'glymphatic'"},{"target_artifact_id":"experiment-exp-wiki-experiments-astrocyte-ferritin-iron-metabolism-pd","link_type":"mentions","strength":0.5,"evidence":"Content: BMAL1 mentioned 12x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"target_artifact_id":"experiment-exp-debate-04d85ea1e5d1","link_type":"mentions","strength":0.5,"evidence":"Content: BMAL1 mentioned 12x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"target_artifact_id":"experiment-exp-wiki-experiments-experiment-index","link_type":"mentions","strength":0.5,"evidence":"Content: CLOCK mentioned 5x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"target_artifact_id":"experiment-exp-wiki-experiments-sleep-disruption-alzheimers","link_type":"mentions","strength":0.5,"evidence":"Content: CLOCK mentioned 5x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"target_artifact_id":"experiment-exp-wiki-experiments-sleep-circadian-neurodegeneration-mechanism","link_type":"mentions","strength":0.5,"evidence":"Content: CLOCK mentioned 5x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"target_artifact_id":"hypothesis-h-807d7a82","link_type":"mentions","strength":0.6,"evidence":"Content: AQP4 mentioned 14x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"target_artifact_id":"hypothesis-h-c8ccbee8","link_type":"mentions","strength":0.6,"evidence":"Content: AQP4 mentioned 14x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"target_artifact_id":"experiment-exp-wiki-diagnostics-nph-csf-dynamic-biomarkers-differential-diagnosi","link_type":"mentions","strength":0.5,"evidence":"Content: AQP4 mentioned 14x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"target_artifact_id":"experiment-exp-wiki-experiments-nph-csf-dynamic-biomarkers-differential-diagnosi","link_type":"mentions","strength":0.5,"evidence":"Content: AQP4 mentioned 14x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"target_artifact_id":"experiment-exp-wiki-experiments-nph-glymphatic-interaction","link_type":"mentions","strength":0.5,"evidence":"Content: AQP4 mentioned 14x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"target_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-vs-tau-pet-monitoring","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: GFAP mentioned 2x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.3,"evidence":"Transitive: wiki→hypothesis→analysis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.36,"evidence":"Transitive: wiki→hypothesis→analysis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"hypothesis-h-49791706","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-8986b8af","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"hypothesis-h-0791836f","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-1e564178","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"hypothesis-h-cb833ed8","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"hypothesis-h-bb518928","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"hypothesis-h-c463d225","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"hypothesis-h-782b40b1","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"hypothesis-h-fb56c8a0","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-82922df8","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-9eae33ba","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-a9571dbb","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"hypothesis-h-d7121bcc","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-50a535f9","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"hypothesis-h-4113b0e8","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-8597755b","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-6c83282d","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-bdbd2120","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"hypothesis-h-62f9fc90","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"hypothesis-h-0e675a41","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-a90e2e89","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-baba5269","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"experiment-exp-wiki-experiments-circadian-vascular-metabolic-syndrome-ad","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' in experiment title"},{"target_artifact_id":"experiment-exp-wiki-experiments-glymphatic-circadian-axis-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' in experiment title"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"mentions","strength":0.5,"evidence":"Auto: domain match"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v3-20260402063622","link_type":"mentions","strength":0.4,"evidence":"Keyword match: alzheimers"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v4-20260402065846","link_type":"mentions","strength":0.4,"evidence":"Keyword match: alzheimers"},{"target_artifact_id":"wiki-institutions-alzheimer-indonesia","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-mechanisms-angiogenesis","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-experiments-astrocyte-neuron-metabolic-coupling-parkinsons","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-experiments-epigenetic-clocks-neurodegeneration","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-mechanisms-erk-mapk-signaling-neurodegeneration","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-biomarkers-gaba-neurodegenerative-biomarker","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-therapeutics-huntington-disease-treatment","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-brain-regions-hypothalamus","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-diseases-neurodegeneration","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-diagnostics-cbs-psp-neuroinflammation-pet","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-companies-neuron-therapeutics","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"hypothesis-h-3d545f4e","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"hypothesis-h-15336069","link_type":"mentions","strength":0.5,"evidence":"Entity 'CIRCADIAN' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"hypothesis-h-seaad-56fa6428","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene GFAP"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'circadian'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'CIRCADIAN'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'hypotheses'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'hypotheses'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'hypotheses'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'hypotheses'"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-807d7a82","link_type":"related","strength":0.54,"evidence":"Reverse: Content: AQP4 mentioned 14x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"source_artifact_id":"hypothesis-h-c8ccbee8","link_type":"related","strength":0.54,"evidence":"Reverse: Content: AQP4 mentioned 14x in wiki/hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"hypothesis-h-57862f8a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-a1b56d74","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-5706bbd7","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-7e0b5ade","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-62e56eb9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-3d993b5d","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-019ad538","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ae1b2beb","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-b0cda336","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-0e0cc0c1","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-83efeed6","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-38292315","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-9e9fee95","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-41bc2d38","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-de579caf","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-b7898b79","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6b84d8e2","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-49791706","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-8986b8af","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-0791836f","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1e564178","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-cb833ed8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-bb518928","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-c463d225","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-782b40b1","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-fb56c8a0","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-82922df8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-9eae33ba","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-a9571dbb","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-d7121bcc","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-50a535f9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-4113b0e8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-8597755b","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6c83282d","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-bdbd2120","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-62f9fc90","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-0e675a41","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-a90e2e89","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-baba5269","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v3-20260402063622","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v4-20260402065846","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-001","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers","is_canonical":true,"supersede_chain":["wiki-hypotheses-circadian-glymphatic-metabolic-coupling-alzheimers"]}