{"artifact":{"id":"wiki-ideas-mitochondrial-nad-redox-swing-protocol","artifact_type":"wiki_page","entity_ids":"[\"ideas-mitochondrial-nad-redox-swing-protocol\"]","title":"Mitochondrial NAD Redox Swing Protocol with Temporal Dosing Windows","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"b96b45bf81004e96133e465efc35e513196db3c3e1310fbaabbc8e06be8cac99","metadata":{"slug":"ideas-mitochondrial-nad-redox-swing-protocol","kg_node_id":null,"entity_type":"idea","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-71cc53f36cf2","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"ideas-mitochondrial-nad-redox-swing-protocol"},"_schema_version":1},"created_at":"2026-04-02T07:19:34-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"1e0e14eb-0902-49d4-8058-8a9f43d80739","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"hypothesis-h-827a821b","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 5x in wiki/ideas-mitochondrial-nad-redox-swing-protocol"},{"target_artifact_id":"experiment-exp-9f358501-0c3d-417e-9b43-1be792ee3638","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 5x in wiki/ideas-mitochondrial-nad-redox-swing-protocol"},{"target_artifact_id":"experiment-exp-778c1bc2-7c6e-4cdd-81af-56c535ead1e3","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: AMPK mentioned 2x in wiki/ideas-mitochondrial-nad-redox-swing-protocol"},{"target_artifact_id":"experiment-exp-545ecac0-8b8e-4dc1-b999-1118f810815a","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: AMPK mentioned 2x in wiki/ideas-mitochondrial-nad-redox-swing-protocol"},{"target_artifact_id":"experiment-exp-bdbae77a-4e67-498f-be15-d4c6c33ac1ec","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: AMPK mentioned 2x in wiki/ideas-mitochondrial-nad-redox-swing-protocol"},{"target_artifact_id":"hypothesis-h-d2df6eaf","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Protocol'"},{"target_artifact_id":"hypothesis-h-aa8b4952","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mitochondrial'"},{"target_artifact_id":"hypothesis-h-969bd8e0","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mitochondrial'"},{"target_artifact_id":"hypothesis-h-23a3cc07","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'with'"},{"target_artifact_id":"hypothesis-h-019ad538","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Temporal'"},{"target_artifact_id":"hypothesis-h-0791836f","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mitochondrial'"},{"target_artifact_id":"hypothesis-h-1a34778f","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mitochondrial'"},{"target_artifact_id":"hypothesis-h-13bbfdc5","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mitochondrial'"},{"target_artifact_id":"hypothesis-h-1e2bd420","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mitochondrial'"},{"target_artifact_id":"hypothesis-h-43f72e21","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'mitochondrial'"},{"target_artifact_id":"hypothesis-h-fd1562a3","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'mitochondrial'"},{"target_artifact_id":"hypothesis-h-98b431ba","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'mitochondrial'"},{"target_artifact_id":"hypothesis-h-250b34ab","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'mitochondrial'"},{"target_artifact_id":"hypothesis-h-6ce4884a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'mitochondrial'"},{"target_artifact_id":"hypothesis-h-346639e8","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'mitochondrial'"},{"target_artifact_id":"hypothesis-h-13ef5927","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'mitochondrial'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'Mitochondrial'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mitochondrial'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mitochondrial'"},{"target_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"mentions","strength":0.6,"evidence":"Content: SIRT1 mentioned 5x in wiki/ideas-mitochondrial-nad-redox-swing-protocol"},{"target_artifact_id":"experiment-exp-wiki-experiments-epigenetic-clocks-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Content: SIRT1 mentioned 5x in wiki/ideas-mitochondrial-nad-redox-swing-protocol"},{"target_artifact_id":"hypothesis-h-69919c49","link_type":"mentions","strength":0.5,"evidence":"Content: PARP1 mentioned 2x in wiki/ideas-mitochondrial-nad-redox-swing-protocol"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.3,"evidence":"Transitive: wiki→hypothesis→analysis"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.9,"evidence":"Wiki page mentions gene TH targeted by hypothesis"},{"target_artifact_id":"experiment-exp-wiki-experiments-sirtuin-pathway-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for NAD related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-51e7234f","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene MTOR"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-827a821b","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 5x in wiki/ideas-mitochondrial-nad-redox-swing-protocol"},{"source_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"related","strength":0.54,"evidence":"Reverse: Content: SIRT1 mentioned 5x in wiki/ideas-mitochondrial-nad-redox-swing-protocol"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-sirtuin-pathway-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets NAD described in wiki"},{"source_artifact_id":"hypothesis-h-d2df6eaf","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-aa8b4952","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-969bd8e0","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-23a3cc07","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-019ad538","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-0791836f","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1a34778f","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-13bbfdc5","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1e2bd420","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-43f72e21","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-fd1562a3","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-98b431ba","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-250b34ab","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6ce4884a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-346639e8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-13ef5927","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-69919c49","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-ideas-mitochondrial-nad-redox-swing-protocol","is_canonical":true,"supersede_chain":["wiki-ideas-mitochondrial-nad-redox-swing-protocol"]}