{"artifact":{"id":"wiki-ideas-payload-autophagy-proteostasis-dual-activation","artifact_type":"wiki_page","entity_ids":"[\"ideas-payload-autophagy-proteostasis-dual-activation\"]","title":"Payload: Autophagy Proteostasis Dual Activation","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"cf665ee908c94cd34676745c77e0b815d28dc002dfb1ca88e73ad965032afcef","metadata":{"slug":"ideas-payload-autophagy-proteostasis-dual-activation","kg_node_id":null,"entity_type":"idea","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-e30092bcd4cc","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"ideas-payload-autophagy-proteostasis-dual-activation"},"_schema_version":1},"created_at":"2026-04-02T07:19:35-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"26fc2d7c-40e5-44f7-a5e2-4f15d011f8b0","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-f700c392-bfd0-4fe7-89ac-4e4f696413cb","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 5x in wiki/ideas-payload-autophagy-proteostasis-dual-activation"},{"target_artifact_id":"experiment-exp-6c42097c-1042-4686-bacf-d5adc29cd868","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 5x in wiki/ideas-payload-autophagy-proteostasis-dual-activation"},{"target_artifact_id":"experiment-exp-b939a41c-0445-4658-bdaf-1f08759e2dc4","link_type":"mentions","strength":0.5,"evidence":"Content: TFEB mentioned 5x in wiki/ideas-payload-autophagy-proteostasis-dual-activation"},{"target_artifact_id":"hypothesis-h-d2722680","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Activation'"},{"target_artifact_id":"hypothesis-h-23a3cc07","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Dual'"},{"target_artifact_id":"hypothesis-h-7e0b5ade","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Activation'"},{"target_artifact_id":"hypothesis-h-ae1b2beb","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Autophagy'"},{"target_artifact_id":"hypothesis-h-0e0cc0c1","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Proteostasis'"},{"target_artifact_id":"hypothesis-h-b7898b79","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Autophagy'"},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Autophagy'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'autophagy'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-microglial-subtypes-20260402004119","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'activation'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'autophagy'"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for CT related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"mentions","strength":0.4,"evidence":"Pathway match: proteostasis"},{"target_artifact_id":"hypothesis-h-637a53c9","link_type":"mentions","strength":0.4,"evidence":"Pathway match: proteostasis"},{"target_artifact_id":"hypothesis-h-51e7234f","link_type":"related","strength":0.5,"evidence":"Wiki content mentions gene MTOR"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-e5a1c16b","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TFEB"},{"target_artifact_id":"hypothesis-h-e3e8407c","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TFEB"}],"incoming_links":[{"source_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets CT described in wiki"},{"source_artifact_id":"hypothesis-h-d2722680","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-23a3cc07","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-7e0b5ade","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ae1b2beb","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-0e0cc0c1","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-b7898b79","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-microglial-subtypes-20260402004119","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-ideas-payload-autophagy-proteostasis-dual-activation","is_canonical":true,"supersede_chain":["wiki-ideas-payload-autophagy-proteostasis-dual-activation"]}