{"artifact":{"id":"wiki-ideas-payload-lrp1-perivascular-drainage","artifact_type":"wiki_page","entity_ids":"[\"ideas-payload-lrp1-perivascular-drainage\"]","title":"LRP1-Enhanced Perivascular Drainage Therapy","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"b4e074bb9a229abea0cd97085de518e64cf8d5fca6f435eada49484f1d2bc948","metadata":{"slug":"ideas-payload-lrp1-perivascular-drainage","kg_node_id":null,"entity_type":"idea","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-a2eb633918d6","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"ideas-payload-lrp1-perivascular-drainage"},"_schema_version":1},"created_at":"2026-04-02T07:19:35-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"5fd99477-2ef4-4fa1-b236-0136b82d1e79","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-mechanisms-microglial-priming-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-paranodal-dysfunction-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-down-syndrome-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-sleep-dysfunction-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-lysosomal-calcium-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-gangliosides-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-neuronal-hyperexcitability","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-ghrelin-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-camkii-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-neuropil-threads-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-nuclear-pore-complex-dysfunction-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-p-body-processing-bodies-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-diffusion-mri-dti-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-dystrophic-neurites-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-vip-vasoactive-intestinal-peptide-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-serotonergic-dysfunction","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-short-chain-fatty-acids","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-chrononutrition-time-restricted-eating","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-gp130-il6-family-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-hippocampal-neurogenesis-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-prion-diseases-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-cerebral-amyloid-angiopathy-pathway","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"target_artifact_id":"wiki-mechanisms-psp-cortical-involvement-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-antisense-oligonucleotide-therapy-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-nlrp3-inflammasome-inhibitors-parkinsons","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-retinal-degeneration-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-molecular-chaperones","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-kidney-brain-neurodegeneration-axis","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-covid-19-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-endosomal-lysosomal-pathway","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"target_artifact_id":"wiki-mechanisms-endothelin-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-osk-reprogramming-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-interleukin-6-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-ppar-signaling-neurodegeneration","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"target_artifact_id":"wiki-mechanisms-peripheral-immune-brain-crosstalk","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-convergent-pathways-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"related","strength":0.4,"evidence":"KG edge: AADC --[co_discussed]--> LRP1"},{"target_artifact_id":"analysis-SDA-2026-04-04-gap-senescent-clearance-neuro","link_type":"related","strength":0.4,"evidence":"KG edge: BCL2L1 --[co_discussed]--> LRP1"},{"target_artifact_id":"analysis-SDA-2026-04-04-gap-tau-prop-20260402003221","link_type":"related","strength":0.4,"evidence":"KG edge: CHMP4B --[co_associated_with]--> LRP1"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-005","link_type":"related","strength":0.4,"evidence":"KG edge: LRP1 --[co_discussed]--> TAU"},{"target_artifact_id":"experiment-exp-296c7d3d-0631-464d-9fa5-40e2a9450f46","link_type":"mentions","strength":0.8,"evidence":"Gene target: LRP1"},{"target_artifact_id":"experiment-exp-21448d10-6b1e-46da-bf4f-9015f3fe1cde","link_type":"mentions","strength":0.8,"evidence":"Gene target: LRP1"},{"target_artifact_id":"hypothesis-h-84808267","link_type":"mentions","strength":0.7,"evidence":"Gene match: LRP1"},{"target_artifact_id":"hypothesis-h-7e0b5ade","link_type":"mentions","strength":0.7,"evidence":"Gene match: LRP1"},{"target_artifact_id":"hypothesis-h-b948c32c","link_type":"mentions","strength":0.7,"evidence":"Gene match: LRP1"},{"target_artifact_id":"hypothesis-h-4dd0d19b","link_type":"mentions","strength":0.7,"evidence":"Gene match: LRP1"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.648,"evidence":"KG edge: ABCB1 --[interacts_with]--> LRP1"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.7,"evidence":"KG edge: LRP1 --[modulates]--> LRP1-Dependent Tau Uptake Disruption"},{"target_artifact_id":"hypothesis-h-d40d2659","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-c35493aa","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-69919c49","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-19003961","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-62e56eb9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Enhanced'"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-8ef34c4c","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-ac55ff26","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-c463d225","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-f99ce4ca","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-1fe4ba9b","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-43f72e21","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'enhanced'"},{"target_artifact_id":"hypothesis-h-fd1562a3","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'therapy'"},{"target_artifact_id":"hypothesis-h-d7121bcc","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-50a535f9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-de579caf","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-8597755b","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-6b84d8e2","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-de0d4364","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-2600483e","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-12599989","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-bdbd2120","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'therapy'"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"analysis-sda-2026-04-01-002","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapy'"},{"target_artifact_id":"hypothesis-h-55ef81c5","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'Perivascular'"},{"target_artifact_id":"hypothesis-h-0f00fd75","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-73e29e3a","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-fdaae8d9","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-05b8894a","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapy'"},{"target_artifact_id":"hypothesis-h-aa2d317c","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'perivascular'"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-pet-therapeutic-response-prediction","link_type":"mentions","strength":0.5,"evidence":"Content: LRP1 mentioned 27x in wiki/ideas-payload-lrp1-perivascular-drainage"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-propagation-causality","link_type":"mentions","strength":0.5,"evidence":"Content: LRP1 mentioned 27x in wiki/ideas-payload-lrp1-perivascular-drainage"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-immunotherapy-dosing","link_type":"mentions","strength":0.5,"evidence":"Content: LRP1 mentioned 27x in wiki/ideas-payload-lrp1-perivascular-drainage"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.5,"evidence":null},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"mentions","strength":0.5,"evidence":null},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"mentions","strength":0.5,"evidence":null},{"target_artifact_id":"hypothesis-h-5daecb6e","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-6657f7cd","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-e6437136","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-c8ccbee8","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-5a55aabc","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-23a3cc07","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-7a8d7379","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.3,"evidence":"Transitive: wiki→hypothesis→analysis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.24,"evidence":"Transitive: wiki→hypothesis→analysis"},{"target_artifact_id":"hypothesis-h-5daecb6e","link_type":"mentions","strength":0.5,"evidence":"Entity 'LRP1' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'LRP1'"},{"target_artifact_id":"hypothesis-h-5a55aabc","link_type":"mentions","strength":0.5,"evidence":"Entity 'LRP1' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.5,"evidence":"Entity 'LRP1' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'LRP1'"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.5,"evidence":"Entity 'LRP1' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.5,"evidence":"Entity 'LRP1' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-73e4340b","link_type":"mentions","strength":0.5,"evidence":"Entity 'LRP1' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'LRP1'"},{"target_artifact_id":"hypothesis-h-e7e1f943","link_type":"mentions","strength":0.5,"evidence":"Entity 'LRP1' mentioned in hypothesis description/evidence"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-intracellular-vs-extracellular-comparis","link_type":"mentions","strength":0.7,"evidence":"Gene mention: LRP1"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-spreading-network-mapping-psp","link_type":"mentions","strength":0.7,"evidence":"Gene mention: LRP1"},{"target_artifact_id":"experiment-exp-wiki-experiments-4r-tau-targeting-psp-cbs","link_type":"mentions","strength":0.7,"evidence":"Gene mention: LRP1"},{"target_artifact_id":"experiment-exp-wiki-experiments-cbs-psp-phenotype-determinants","link_type":"mentions","strength":0.7,"evidence":"Gene mention: LRP1"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-pathology-initiation-zone","link_type":"mentions","strength":0.7,"evidence":"Gene mention: LRP1"},{"target_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"mentions","strength":0.7,"evidence":"Gene mention: LRP1"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"mentions","strength":0.7,"evidence":"Gene mention: LRP1"},{"target_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-vs-tau-pet-monitoring","link_type":"mentions","strength":0.7,"evidence":"Gene mention: LRP1"},{"target_artifact_id":"experiment-exp-wiki-experiments-toxin-microbiome-parkinsons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: LRP1"},{"target_artifact_id":"experiment-exp-debate-ca942ead922d","link_type":"mentions","strength":0.7,"evidence":"Gene mention: LRP1"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.7,"evidence":"KG edge: LRP1 --[expressed_in]--> \"middle temporal gyrus\"_aspiny_L3"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.9,"evidence":"Wiki page mentions gene TH targeted by hypothesis"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-pet-therapeutic-response-prediction","link_type":"related","strength":0.7,"evidence":"Wiki page for LRP1 related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-propagation-causality","link_type":"related","strength":0.7,"evidence":"Wiki page for LRP1 related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-immunotherapy-dosing","link_type":"related","strength":0.7,"evidence":"Wiki page for LRP1 related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-senescent-clearance-neuro","link_type":"mentions","strength":0.5,"evidence":null},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-seaad-56fa6428","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-seaad-7f15df4c","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-seaad-5b3cb8ea","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"related","strength":0.4,"evidence":null},{"target_artifact_id":"hypothesis-h-35f04e1b","link_type":"mentions","strength":0.4,"evidence":"Pathway match: vascular"},{"target_artifact_id":"hypothesis-h-fb56c8a0","link_type":"mentions","strength":0.4,"evidence":"Pathway match: vascular"},{"target_artifact_id":"hypothesis-h-807d7a82","link_type":"mentions","strength":0.5,"evidence":"KG transitive via AQP4"},{"target_artifact_id":"hypothesis-h-5706bbd7","link_type":"mentions","strength":0.5,"evidence":"KG transitive via BMAL1"},{"target_artifact_id":"hypothesis-h-019ad538","link_type":"mentions","strength":0.5,"evidence":"KG transitive via CLOCK"},{"target_artifact_id":"hypothesis-h-b7898b79","link_type":"mentions","strength":0.5,"evidence":"KG transitive via CLOCK"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-ae1b2beb","link_type":"mentions","strength":0.5,"evidence":"KG transitive via FOXO1"},{"target_artifact_id":"hypothesis-h-3f02f222","link_type":"mentions","strength":0.5,"evidence":"KG transitive via BCL2L1"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.5,"evidence":"KG transitive via TREM2"},{"target_artifact_id":"hypothesis-h-fd52a7a0","link_type":"mentions","strength":0.5,"evidence":"KG transitive via FOXO3"},{"target_artifact_id":"hypothesis-h-856feb98","link_type":"mentions","strength":0.5,"evidence":"KG transitive via BDNF"},{"target_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"mentions","strength":0.5,"evidence":"KG transitive via SIRT1"},{"target_artifact_id":"wiki-genes-abca2","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-genes-abi3","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-genes-ace","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-genes-adam17","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-genes-aifm1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-genes-abca1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-genes-abcb1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-mechanisms-aging-vs-neurodegeneration-comparison","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"target_artifact_id":"hypothesis-h-7e0b5ade","link_type":"related","strength":0.4,"evidence":"KG bridge: LRP1 ↔ LRP1, MTNR1A, MTNR1B"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"mentions","strength":0.5,"evidence":"Entity 'LRP1' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-a87702b6","link_type":"mentions","strength":0.5,"evidence":"Entity 'LRP1' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'LRP1'"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"mentions","strength":0.5,"evidence":"Entity 'LRP1' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'LRP1'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-seaad-v4-26ba859b","link_type":"related","strength":0.55,"evidence":"Shared KG edge: ACSL4 → LRP1"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"experiment-exp-debate-0303c1c48688","link_type":"related","strength":0.5,"evidence":"Experiment from analysis studying entity in wiki page"},{"target_artifact_id":"experiment-exp-debate-b68856276b4a","link_type":"related","strength":0.5,"evidence":"Experiment from analysis studying entity in wiki page"},{"target_artifact_id":"hypothesis-h-15336069","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"mentions","strength":0.75,"evidence":"Gene mention: LRP1"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-senescent-clearance-neuro","link_type":"related","strength":0.4,"evidence":"KG edge: BCL2L1 --[co_discussed]--> LRP1"},{"target_artifact_id":"wiki-biomarkers-neuroimaging-biomarkers-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-biomarkers-interleukin-6-il6-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-biomarkers-cell-free-dna-biomarkers","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-biomarkers-exosomal-biomarkers-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-biomarkers-metabolomic-biomarkers-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-biomarkers-liquid-biopsy-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-biomarkers-synaptic-biomarkers","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-biomarkers-exosomal-mir155","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-beacon-study-nct03860857","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-olfactory-mucosa-early-neurodegeneration-nct06846658","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-nct07094516-novartis-alzheimers-phase2","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-nct07177352","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-admsc-stem-cell-early-ad-nct06775964","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-nct03634007-lx1001-phase-1-2","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-nct07062198","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-rotigotine-rivastigmine-combo-alzheimers","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-nct06976203","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-swedish-biofinder-2-psp-nct03174938","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-nbia","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-mpan","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-india-neurodegeneration-epidemiology","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-cancer-dementia-inverse-correlation","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-diseases-pla2g6-associated-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-bpan","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-japan-neurodegeneration-epidemiology","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-european-neurodegeneration-epidemiology","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-economic-burden-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-global-neurodegeneration-epidemiology","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-cancer-dementia-correlation","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-diseases-neurodegeneration-impact-measures","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-pantothenate-kinase-associated-neurodegeneration-pkan","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-china-neurodegeneration-epidemiology","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-apoe4","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-diseases-disease-progression","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-sleep-disorders-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-pkan","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-mitochondrial-dysfunction-neurodegeneration-comparison","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-familial-vs-sporadic-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-mitochondrial-neurodegeneration-comparison","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-daly-methodology-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-us-neurodegeneration-epidemiology","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-diseases-manganism","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-entities-snca","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-extracellular-vesicle-tnt-mediated-spreading-comparison","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"target_artifact_id":"wiki-mechanisms-neurotensin-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-epigenetics-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-r-loop-stress-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-neural-circuit-disruption","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-mitochondrial-fusion-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-escrit-iii-inhibition-alpha-synuclein","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-magnetic-resonance-spectroscopy","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-igf-1-signaling-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-metal-homeostasis-dysregulation","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-circuits","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-tertiary-lymphoid-organs-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-glycosylation-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-mineralocorticoid-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-sex-differences-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-fxr-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-neurofilament-light-chain-nfl-mechanism","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-ribosome-dysfunction","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-ion-channel-dysfunction-comparison","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-autosis-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-pericyte-loss","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-npy-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-prognostic-biomarkers-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-cerebral-amyloid-angiopathy-neurodegeneration","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"target_artifact_id":"wiki-mechanisms-parthanatos","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-hmgb1-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-rnasek-circular-rnas-aging","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-neurexin-neuroligin-neurodegeneration-modulation","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-lipid-metabolism-dysregulation-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-rna-splicing","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-metal-homeostasis-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-computational-disease-models-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-copper-homeostasis-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-ubiquitin-proteasome-dysfunction-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-nfkb-signaling-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-sigma1-receptor-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-sirtuin-mitochondrial-biogenesis-axis","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-intrinsic-apoptosis-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-protein-aggregation-seeds-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-advanced-glycation-end-products","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-antibody-therapy-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-gdnf-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-carbonic-anhydrase-modulator-therapy-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-paraptosis-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-advanced-in-vitro-models-neurodegeneration-synthesis","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-transdiagnostic-proteomics","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-gdf15-gdf11-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-nitric-oxide-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-wnt-beta-catenin-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-senescence-clearance","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"target_artifact_id":"wiki-mechanisms-fa2h-associated-neurodegeneration-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-becn1-autophagy-initiation-neurodegeneration-causal-chain","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-axon-guidance-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-integrated-stress-response","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-ubiquitin-proteasome-system","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-protein-o-glcna-cylation-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-wnk1-bilirubin-signaling-neuroinflammation","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-sumoylation-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-neurovascular-unit-dysfunction","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"target_artifact_id":"wiki-mechanisms-lipid-dysregulation-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-rna-targeted-therapies-neurodegeneration","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"target_artifact_id":"wiki-mechanisms-digital-phenotyping-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-prion-like-spread","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-pkr-pathway-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-cholinergic-system-dysfunction-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-purinergic-signaling","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-vegf-angiogenesis-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-noradrenergic-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-glucocorticoid-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-prion-protein-metabolism","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-ran-translation","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-s100-protein-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-microrna-dysfunction","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-mtor-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-acetylcholine-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-nrf2-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-therapeutic-targets-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-homocysteine-neurotoxicity","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-mitochondrial-dynamics-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-il-1-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-histone-modification-pathway-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-t-cell-dysfunction","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-endosomal-sorting-defects-neurodegeneration","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"target_artifact_id":"wiki-mechanisms-progesterone-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-protein-aggregation-comparison","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-vagus-nerve-pathway-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-quantum-biology-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-cognitive-reserve","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-synaptic-vesicle-cycling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-synthetic-lethality-parp-inhibition","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-transdiagnostic-proteomic-changes","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-basal-ganglia-circuit-dysfunction-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-ad-mechanism-index","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-mtor-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-endocannabinoid-system","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-galectin-3-mechanism-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-orexin-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"wiki-mechanisms-amylin-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'LRP1'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"}],"incoming_links":[{"source_artifact_id":"wiki-mechanisms-microglial-priming-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-paranodal-dysfunction-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-down-syndrome-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-sleep-dysfunction-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-lysosomal-calcium-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-gangliosides-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-neuronal-hyperexcitability","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-ghrelin-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-camkii-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-neuropil-threads-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-nuclear-pore-complex-dysfunction-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-p-body-processing-bodies-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-diffusion-mri-dti-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-dystrophic-neurites-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-vip-vasoactive-intestinal-peptide-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-serotonergic-dysfunction","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-short-chain-fatty-acids","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-chrononutrition-time-restricted-eating","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-gp130-il6-family-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-hippocampal-neurogenesis-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-prion-diseases-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-cerebral-amyloid-angiopathy-pathway","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"source_artifact_id":"wiki-mechanisms-psp-cortical-involvement-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-antisense-oligonucleotide-therapy-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-nlrp3-inflammasome-inhibitors-parkinsons","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-retinal-degeneration-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-molecular-chaperones","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-kidney-brain-neurodegeneration-axis","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-covid-19-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-endosomal-lysosomal-pathway","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"source_artifact_id":"wiki-mechanisms-endothelin-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-osk-reprogramming-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-interleukin-6-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-ppar-signaling-neurodegeneration","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"source_artifact_id":"wiki-mechanisms-peripheral-immune-brain-crosstalk","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-convergent-pathways-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"experiment-exp-wiki-experiments-anti-tau-intracellular-vs-extracellular-comparis","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: LRP1"},{"source_artifact_id":"experiment-exp-wiki-experiments-tau-spreading-network-mapping-psp","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: LRP1"},{"source_artifact_id":"experiment-exp-wiki-experiments-4r-tau-targeting-psp-cbs","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: LRP1"},{"source_artifact_id":"experiment-exp-wiki-experiments-cbs-psp-phenotype-determinants","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: LRP1"},{"source_artifact_id":"experiment-exp-wiki-experiments-tau-pathology-initiation-zone","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: LRP1"},{"source_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: LRP1"},{"source_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: LRP1"},{"source_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-vs-tau-pet-monitoring","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: LRP1"},{"source_artifact_id":"experiment-exp-wiki-experiments-toxin-microbiome-parkinsons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: LRP1"},{"source_artifact_id":"experiment-exp-debate-ca942ead922d","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: LRP1"},{"source_artifact_id":"experiment-exp-296c7d3d-0631-464d-9fa5-40e2a9450f46","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: LRP1"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: LRP1"},{"source_artifact_id":"experiment-exp-21448d10-6b1e-46da-bf4f-9015f3fe1cde","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: LRP1"},{"source_artifact_id":"hypothesis-h-4dd0d19b","link_type":"mentions","strength":0.8,"evidence":"Hypothesis involves entity 'LRP1' with wiki page"},{"source_artifact_id":"hypothesis-h-84808267","link_type":"related","strength":0.63,"evidence":"Reverse: Gene match: LRP1"},{"source_artifact_id":"hypothesis-h-7e0b5ade","link_type":"related","strength":0.63,"evidence":"Reverse: Gene match: LRP1"},{"source_artifact_id":"hypothesis-h-b948c32c","link_type":"related","strength":0.63,"evidence":"Reverse: Gene match: LRP1"},{"source_artifact_id":"hypothesis-h-4dd0d19b","link_type":"related","strength":0.63,"evidence":"Reverse: Gene match: LRP1"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5832,"evidence":"Reverse: KG edge: ABCB1 --[interacts_with]--> LRP1"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.63,"evidence":"Reverse: KG edge: LRP1 --[modulates]--> LRP1-Dependent Tau Uptake Disruption"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-tau-pet-therapeutic-response-prediction","link_type":"related","strength":0.7,"evidence":"Experiment targets LRP1 described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-tau-propagation-causality","link_type":"related","strength":0.7,"evidence":"Experiment targets LRP1 described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-anti-tau-immunotherapy-dosing","link_type":"related","strength":0.7,"evidence":"Experiment targets LRP1 described in wiki"},{"source_artifact_id":"hypothesis-h-d40d2659","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-c35493aa","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-69919c49","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-19003961","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-62e56eb9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-8ef34c4c","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ac55ff26","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-c463d225","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-f99ce4ca","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1fe4ba9b","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-43f72e21","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-fd1562a3","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-d7121bcc","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-50a535f9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-de579caf","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-8597755b","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6b84d8e2","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-de0d4364","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-2600483e","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-12599989","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-bdbd2120","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-5daecb6e","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-5a55aabc","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-d0a564e8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-73e4340b","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-e7e1f943","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"wiki-experiments-astrocyte-neuron-metabolic-coupling-parkinsons","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-arf1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-aifm1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-sema3f","link_type":"see_also","strength":0.6,"evidence":"KG edge: expressed_in"},{"source_artifact_id":"wiki-genes-gata1","link_type":"see_also","strength":0.6,"evidence":"KG edge: interacts_with"},{"source_artifact_id":"wiki-genes-mt1a","link_type":"see_also","strength":0.6,"evidence":"KG edge: interacts_with"},{"source_artifact_id":"wiki-proteins-lrp4","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-proteins-nos1","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-proteins-lrp5","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-proteins-lrp1b","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-proteins-arf1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-lrp4","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-genes-nos1","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-genes-timp1","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-genes-lrp5","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-genes-lrp1b","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-genes-tcf3","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-pin1","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"hypothesis-h-7a8d7379","link_type":"related","strength":0.4,"evidence":"KG bridge: LRP1 ↔ CLDN5, OCLN"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-senescent-clearance-neuro","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-002","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"hypothesis-h-84808267","link_type":"see_also","strength":0.7,"evidence":"Hypothesis targets gene LRP1 discussed in wiki page"},{"source_artifact_id":"hypothesis-h-7e0b5ade","link_type":"see_also","strength":0.7,"evidence":"Hypothesis targets gene LRP1 discussed in wiki page"},{"source_artifact_id":"hypothesis-h-b948c32c","link_type":"see_also","strength":0.7,"evidence":"Hypothesis targets gene LRP1 discussed in wiki page"},{"source_artifact_id":"hypothesis-h-4dd0d19b","link_type":"see_also","strength":0.7,"evidence":"Hypothesis targets gene LRP1 discussed in wiki page"},{"source_artifact_id":"wiki-biomarkers-neuroimaging-biomarkers-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-biomarkers-interleukin-6-il6-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-biomarkers-cell-free-dna-biomarkers","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-biomarkers-exosomal-biomarkers-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-biomarkers-metabolomic-biomarkers-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-biomarkers-liquid-biopsy-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-biomarkers-synaptic-biomarkers","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-biomarkers-exosomal-mir155","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-beacon-study-nct03860857","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-olfactory-mucosa-early-neurodegeneration-nct06846658","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-nct07094516-novartis-alzheimers-phase2","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-nct07177352","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-admsc-stem-cell-early-ad-nct06775964","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-nct03634007-lx1001-phase-1-2","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-nct07062198","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-rotigotine-rivastigmine-combo-alzheimers","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-nct06976203","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-swedish-biofinder-2-psp-nct03174938","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-nbia","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-mpan","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-india-neurodegeneration-epidemiology","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-cancer-dementia-inverse-correlation","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-diseases-pla2g6-associated-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-bpan","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-japan-neurodegeneration-epidemiology","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-european-neurodegeneration-epidemiology","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-economic-burden-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-global-neurodegeneration-epidemiology","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-cancer-dementia-correlation","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-diseases-neurodegeneration-impact-measures","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-pantothenate-kinase-associated-neurodegeneration-pkan","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-china-neurodegeneration-epidemiology","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-apoe4","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-diseases-disease-progression","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-sleep-disorders-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-pkan","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-mitochondrial-dysfunction-neurodegeneration-comparison","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-familial-vs-sporadic-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-mitochondrial-neurodegeneration-comparison","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-daly-methodology-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-us-neurodegeneration-epidemiology","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-diseases-manganism","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-entities-snca","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-extracellular-vesicle-tnt-mediated-spreading-comparison","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"source_artifact_id":"wiki-mechanisms-neurotensin-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-epigenetics-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-r-loop-stress-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-neural-circuit-disruption","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-fusion-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-escrit-iii-inhibition-alpha-synuclein","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-magnetic-resonance-spectroscopy","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-igf-1-signaling-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-metal-homeostasis-dysregulation","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-circuits","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-tertiary-lymphoid-organs-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-glycosylation-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-mineralocorticoid-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-sex-differences-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-fxr-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-neurofilament-light-chain-nfl-mechanism","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-ribosome-dysfunction","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-ion-channel-dysfunction-comparison","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-autosis-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-pericyte-loss","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-npy-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-prognostic-biomarkers-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-cerebral-amyloid-angiopathy-neurodegeneration","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"source_artifact_id":"wiki-mechanisms-parthanatos","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-hmgb1-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-rnasek-circular-rnas-aging","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-neurexin-neuroligin-neurodegeneration-modulation","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-lipid-metabolism-dysregulation-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-rna-splicing","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-metal-homeostasis-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-computational-disease-models-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-copper-homeostasis-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-ubiquitin-proteasome-dysfunction-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-nfkb-signaling-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-sigma1-receptor-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-sirtuin-mitochondrial-biogenesis-axis","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-intrinsic-apoptosis-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-protein-aggregation-seeds-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-advanced-glycation-end-products","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-antibody-therapy-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-gdnf-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-carbonic-anhydrase-modulator-therapy-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-paraptosis-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-advanced-in-vitro-models-neurodegeneration-synthesis","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-transdiagnostic-proteomics","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-gdf15-gdf11-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-nitric-oxide-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-wnt-beta-catenin-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-senescence-clearance","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"source_artifact_id":"wiki-mechanisms-fa2h-associated-neurodegeneration-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-becn1-autophagy-initiation-neurodegeneration-causal-chain","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-axon-guidance-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-integrated-stress-response","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-ubiquitin-proteasome-system","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-protein-o-glcna-cylation-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-wnk1-bilirubin-signaling-neuroinflammation","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-sumoylation-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-neurovascular-unit-dysfunction","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"source_artifact_id":"wiki-mechanisms-lipid-dysregulation-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-rna-targeted-therapies-neurodegeneration","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"source_artifact_id":"wiki-mechanisms-digital-phenotyping-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-prion-like-spread","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-pkr-pathway-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-cholinergic-system-dysfunction-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-purinergic-signaling","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-vegf-angiogenesis-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-noradrenergic-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-glucocorticoid-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-prion-protein-metabolism","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-ran-translation","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-s100-protein-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-microrna-dysfunction","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-mtor-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-acetylcholine-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-nrf2-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-therapeutic-targets-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-homocysteine-neurotoxicity","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-mitochondrial-dynamics-pathway","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-il-1-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-histone-modification-pathway-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-t-cell-dysfunction","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-endosomal-sorting-defects-neurodegeneration","link_type":"see_also","strength":0.55,"evidence":"Pages share 5 hypotheses"},{"source_artifact_id":"wiki-mechanisms-progesterone-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-protein-aggregation-comparison","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-vagus-nerve-pathway-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-quantum-biology-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-cognitive-reserve","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-synaptic-vesicle-cycling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-synthetic-lethality-parp-inhibition","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-transdiagnostic-proteomic-changes","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-basal-ganglia-circuit-dysfunction-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-ad-mechanism-index","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-mtor-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-endocannabinoid-system","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-galectin-3-mechanism-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-orexin-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"wiki-mechanisms-amylin-signaling-neurodegeneration","link_type":"see_also","strength":0.5,"evidence":"Pages share 4 hypotheses"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-ideas-payload-lrp1-perivascular-drainage","is_canonical":true,"supersede_chain":["wiki-ideas-payload-lrp1-perivascular-drainage"]}