{"artifact":{"id":"wiki-ideas-payload-nrf2-activator-therapy","artifact_type":"wiki_page","entity_ids":"[\"ideas-payload-nrf2-activator-therapy\"]","title":"NRF2 Activator Therapy","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"dcc1e239381bda7ad1ca936b8bda3cb2a0faf3b07f2b6847fc9a315d2471b91a","metadata":{"slug":"ideas-payload-nrf2-activator-therapy","kg_node_id":null,"entity_type":"idea","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-6bdfacfe9300","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"ideas-payload-nrf2-activator-therapy"},"_schema_version":1},"created_at":"2026-04-02T07:19:34-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"409e1ecf-0473-4da5-9d7b-dac8993d8953","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-46757fd6-b353-4551-b105-757ecff66ef9","link_type":"mentions","strength":0.8,"evidence":"Gene target: NRF2"},{"target_artifact_id":"experiment-exp-82df3491-a40f-4136-a61e-e8b6017cc9a7","link_type":"mentions","strength":0.8,"evidence":"Gene target: NRF2"},{"target_artifact_id":"experiment-exp-25159d1d-2d48-4bb0-bfb1-c59b93dd4dbc","link_type":"mentions","strength":0.8,"evidence":"Gene target: NRF2"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: NRF2"},{"target_artifact_id":"hypothesis-h-d40d2659","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-c35493aa","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-69919c49","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-19003961","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-8ef34c4c","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-ac55ff26","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-c463d225","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-f99ce4ca","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-1fe4ba9b","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-fd1562a3","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'therapy'"},{"target_artifact_id":"hypothesis-h-d7121bcc","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-50a535f9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-de579caf","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-8597755b","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-6b84d8e2","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-de0d4364","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-2600483e","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-12599989","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Therapy'"},{"target_artifact_id":"hypothesis-h-bdbd2120","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'therapy'"},{"target_artifact_id":"analysis-sda-2026-04-01-002","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapy'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'therapy'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.3,"evidence":"Transitive: wiki→hypothesis→analysis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.3,"evidence":"Transitive: wiki→hypothesis→analysis"},{"target_artifact_id":"hypothesis-h-e12109e3","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-76888762","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-a1b56d74","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-7a8d7379","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-637a53c9","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-b0cda336","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-6a065252","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-7957bb2a","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-83efeed6","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-97aa8486","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-38292315","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-43f72e21","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-98b431ba","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-13ef5927","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-e7e1f943","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-ee1df336","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-6c83282d","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-9d29bfe5","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-856feb98","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-0e614ae4","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for CT related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-senescent-clearance-neuro","link_type":"mentions","strength":0.4,"evidence":"Keyword match: therapy"},{"target_artifact_id":"hypothesis-h-82922df8","link_type":"mentions","strength":0.4,"evidence":"Pathway match: nrf2"},{"target_artifact_id":"hypothesis-h-a9571dbb","link_type":"mentions","strength":0.5,"evidence":"KG transitive via HDAC3"},{"target_artifact_id":"hypothesis-h-0e675a41","link_type":"mentions","strength":0.5,"evidence":"KG transitive via HDAC3"},{"target_artifact_id":"hypothesis-h-seaad-56fa6428","link_type":"mentions","strength":0.5,"evidence":"KG transitive via GFAP"},{"target_artifact_id":"wiki-genes-egf","link_type":"see_also","strength":0.6,"evidence":"KG edge: upregulates"},{"target_artifact_id":"wiki-entities-gfap","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"target_artifact_id":"wiki-genes-gpx4","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"target_artifact_id":"wiki-genes-lc3","link_type":"see_also","strength":0.6,"evidence":"KG edge: upstream_of"},{"target_artifact_id":"wiki-entities-pink1-protein","link_type":"see_also","strength":0.6,"evidence":"KG edge: upstream_of"},{"target_artifact_id":"wiki-genes-slc40a1","link_type":"see_also","strength":0.6,"evidence":"KG edge: upregulates"},{"target_artifact_id":"wiki-genes-slc7a11","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"target_artifact_id":"wiki-genes-abcg2","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-entities-acetylcholine","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-genes-acsl4","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-genes-actb","link_type":"see_also","strength":0.6,"evidence":"KG edge: causes"},{"target_artifact_id":"wiki-genes-adam10","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"target_artifact_id":"wiki-mechanisms-aging-vs-neurodegeneration-comparison","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"hypothesis-h-62e56eb9","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-807d7a82","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-seaad-v4-5a7a4079","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v4-20260402065846","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-827a821b","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-e5a1c16b","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-a4e259e0","link_type":"mentions","strength":0.5,"evidence":"Entity 'NRF2' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"hypothesis-h-seaad-v4-26ba859b","link_type":"related","strength":0.55,"evidence":"Shared KG edge: ACSL4 → NRF2"},{"target_artifact_id":"experiment-exp-debate-bb0a058a7032","link_type":"related","strength":0.5,"evidence":"Experiment from analysis studying entity in wiki page"},{"target_artifact_id":"experiment-exp-debate-cc186cfea148","link_type":"related","strength":0.5,"evidence":"Experiment from analysis studying entity in wiki page"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'NRF2'"}],"incoming_links":[{"source_artifact_id":"experiment-exp-46757fd6-b353-4551-b105-757ecff66ef9","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: NRF2"},{"source_artifact_id":"experiment-exp-82df3491-a40f-4136-a61e-e8b6017cc9a7","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: NRF2"},{"source_artifact_id":"experiment-exp-25159d1d-2d48-4bb0-bfb1-c59b93dd4dbc","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: NRF2"},{"source_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: NRF2"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"hypothesis-h-d40d2659","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-c35493aa","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-69919c49","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-19003961","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-8ef34c4c","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ac55ff26","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-c463d225","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-f99ce4ca","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1fe4ba9b","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-fd1562a3","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-d7121bcc","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-50a535f9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-de579caf","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-8597755b","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6b84d8e2","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-de0d4364","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-2600483e","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-12599989","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-bdbd2120","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-e12109e3","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-76888762","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-a1b56d74","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-7a8d7379","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-637a53c9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-b0cda336","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6a065252","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-7957bb2a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-83efeed6","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-97aa8486","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-38292315","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-43f72e21","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-98b431ba","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-13ef5927","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-e7e1f943","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ee1df336","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6c83282d","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-9d29bfe5","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-856feb98","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-0e614ae4","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"wiki-therapeutics-sulforaphane-nrf2-neuroprotection","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-therapeutics-tgr5-agonist-therapy","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-therapeutics-pramipexole","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-clinical-trials-pramipexole-early-pd","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-clinical-trials-genistein-mci-trial-nct07385937","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-proteins-dj-1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-proteins-pgc-1a-protein","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-rcan1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-ape1","link_type":"see_also","strength":0.6,"evidence":"KG edge: interacts_with"},{"source_artifact_id":"wiki-genes-mief1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-slc40a1","link_type":"see_also","strength":0.6,"evidence":"KG edge: upregulates"},{"source_artifact_id":"wiki-genes-dj-1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-sfn","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"source_artifact_id":"wiki-genes-ogg1","link_type":"see_also","strength":0.6,"evidence":"KG edge: inhibits"},{"source_artifact_id":"wiki-genes-nqo2","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"source_artifact_id":"wiki-genes-bap1","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"source_artifact_id":"wiki-genes-dj1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-rnf13","link_type":"see_also","strength":0.6,"evidence":"KG edge: inhibits"},{"source_artifact_id":"wiki-genes-mtrr","link_type":"see_also","strength":0.6,"evidence":"KG edge: expressed_in"},{"source_artifact_id":"wiki-genes-slc7a1","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"source_artifact_id":"wiki-genes-stat4","link_type":"see_also","strength":0.6,"evidence":"KG edge: expressed_in"},{"source_artifact_id":"wiki-mechanisms-oxidative-stress-4r-tauopathies","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"source_artifact_id":"wiki-entities-dj1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v4-20260402065846","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-senescent-clearance-neuro","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-002","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"hypothesis-h-82922df8","link_type":"see_also","strength":0.7,"evidence":"Hypothesis targets gene NRF2 discussed in wiki page"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-ideas-payload-nrf2-activator-therapy","is_canonical":true,"supersede_chain":["wiki-ideas-payload-nrf2-activator-therapy"]}