{"artifact":{"id":"wiki-mechanisms-acly-alpha-synuclein-autophagy","artifact_type":"wiki_page","entity_ids":"[\"mechanisms-acly-alpha-synuclein-autophagy\"]","title":"ACLY Inhibition Rescues Alpha-Synuclein Autophagy","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"6cc74acc25aa7f2a41ff0a5c5c9ad26e16ed7cacdce47988e4d894a812102c03","metadata":{"slug":"mechanisms-acly-alpha-synuclein-autophagy","kg_node_id":null,"entity_type":"mechanism","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-53df95a17566","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"mechanisms-acly-alpha-synuclein-autophagy"},"_schema_version":1},"created_at":"2026-04-02T07:19:52-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"a507a1fa-d5cd-46c8-8479-c8c2d33efb6b","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-3b7faafc-4bd9-407f-ae87-8cfbd6237e51","link_type":"mentions","strength":0.7,"evidence":"Gene mention: ACLY"},{"target_artifact_id":"experiment-exp-546a7e07-4a45-4e78-b0f9-50f2f2fd7e05","link_type":"mentions","strength":0.5,"evidence":"Content: SNCA mentioned 4x in wiki/mechanisms-acly-alpha-synuclein-autophagy"},{"target_artifact_id":"experiment-exp-2e59e044-73e6-418e-9728-5c3a30daa75e","link_type":"mentions","strength":0.5,"evidence":"Content: SNCA mentioned 4x in wiki/mechanisms-acly-alpha-synuclein-autophagy"},{"target_artifact_id":"experiment-exp-cd85e950-e169-432f-a651-510fdde03f01","link_type":"mentions","strength":0.5,"evidence":"Content: SNCA mentioned 4x in wiki/mechanisms-acly-alpha-synuclein-autophagy"},{"target_artifact_id":"experiment-exp-778c1bc2-7c6e-4cdd-81af-56c535ead1e3","link_type":"mentions","strength":0.5,"evidence":"Content: AMPK mentioned 15x in wiki/mechanisms-acly-alpha-synuclein-autophagy"},{"target_artifact_id":"experiment-exp-545ecac0-8b8e-4dc1-b999-1118f810815a","link_type":"mentions","strength":0.5,"evidence":"Content: AMPK mentioned 15x in wiki/mechanisms-acly-alpha-synuclein-autophagy"},{"target_artifact_id":"experiment-exp-bdbae77a-4e67-498f-be15-d4c6c33ac1ec","link_type":"mentions","strength":0.5,"evidence":"Content: AMPK mentioned 15x in wiki/mechanisms-acly-alpha-synuclein-autophagy"},{"target_artifact_id":"hypothesis-h-0e0cc0c1","link_type":"mentions","strength":0.678,"evidence":"Mechanism wiki 'ACLY Inhibition Rescues Alpha-Synuclein Autophagy' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-072b2f5d","link_type":"mentions","strength":0.66,"evidence":"Mechanism wiki 'ACLY Inhibition Rescues Alpha-Synuclein Autophagy' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-74777459","link_type":"mentions","strength":0.653,"evidence":"Mechanism wiki 'ACLY Inhibition Rescues Alpha-Synuclein Autophagy' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'ACLY Inhibition Rescues Alpha-Synuclein Autophagy' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-69919c49","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Inhibition'"},{"target_artifact_id":"hypothesis-h-69d383ea","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Inhibition'"},{"target_artifact_id":"hypothesis-h-7e846ceb","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Inhibition'"},{"target_artifact_id":"hypothesis-h-ae1b2beb","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Autophagy'"},{"target_artifact_id":"hypothesis-h-38292315","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Inhibition'"},{"target_artifact_id":"hypothesis-h-82922df8","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Inhibition'"},{"target_artifact_id":"hypothesis-h-a9571dbb","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Inhibition'"},{"target_artifact_id":"hypothesis-h-b7898b79","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Autophagy'"},{"target_artifact_id":"hypothesis-h-6c83282d","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Synuclein'"},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Autophagy'"},{"target_artifact_id":"hypothesis-h-73e29e3a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Inhibition'"},{"target_artifact_id":"analysis-sda-2026-04-01-002","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'alpha'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'autophagy'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"hypothesis-h-8fe389e8","link_type":"mentions","strength":0.5,"evidence":"Content: HDAC mentioned 2x in wiki/mechanisms-acly-alpha-synuclein-autophagy"},{"target_artifact_id":"experiment-exp-wiki-experiments-epigenetic-regulation-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: HDAC mentioned 2x in wiki/mechanisms-acly-alpha-synuclein-autophagy"},{"target_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"mentions","strength":0.5,"evidence":"Entity 'ACLY' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'ACLY'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"wiki-entities-ampk","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-mechanisms-apoptosis","link_type":"see_also","strength":0.6,"evidence":"KG edge: inhibits"},{"target_artifact_id":"wiki-cell-types-p2x3-receptor-neurons","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-models-a53t-alpha-synuclein-mouse-parkinsons","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-entities-apoptosis","link_type":"see_also","strength":0.6,"evidence":"KG edge: inhibits"},{"target_artifact_id":"wiki-experiments-autophagy-enhancement-drug-screening","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"hypothesis-h-51e7234f","link_type":"related","strength":0.4,"evidence":"KG bridge: ACLY ↔ MTOR"},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-856feb98","link_type":"related","strength":0.55,"evidence":"Shared KG edge: ACLY → BDNF"},{"target_artifact_id":"hypothesis-h-8fe389e8","link_type":"related","strength":0.55,"evidence":"Shared KG edge: ACLY → HDAC"},{"target_artifact_id":"hypothesis-h-a1b56d74","link_type":"related","strength":0.55,"evidence":"Shared KG edge: ACLY → HK2"},{"target_artifact_id":"hypothesis-h-38292315","link_type":"related","strength":0.55,"evidence":"Shared KG edge: ACLY → HK2"},{"target_artifact_id":"hypothesis-h-b295a9dd","link_type":"related","strength":0.55,"evidence":"Shared KG edge: ACLY → LAMP1"},{"target_artifact_id":"hypothesis-h-98b431ba","link_type":"related","strength":0.55,"evidence":"Shared KG edge: ACLY → TFAM"},{"target_artifact_id":"hypothesis-h-ae1b2beb","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"target_artifact_id":"hypothesis-h-5e68b4ad","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"target_artifact_id":"hypothesis-h-74777459","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Alpha-synuclein aggregation / synaptic vesicle"},{"target_artifact_id":"hypothesis-h-8b7727c1","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Bacterial curli amyloid → α-synuclein cross-seeding (gut-brain axis)"},{"target_artifact_id":"hypothesis-h-c9486869","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: HSP70-HSP40 (DNAJB6) chaperone-mediated amyloid inhibition"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-5e68b4ad","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"source_artifact_id":"hypothesis-h-8b7727c1","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Bacterial curli amyloid → α-synuclein cross-seeding (gut-brain axis)"},{"source_artifact_id":"hypothesis-h-c9486869","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: HSP70-HSP40 (DNAJB6) chaperone-mediated amyloid inhibition"},{"source_artifact_id":"experiment-exp-3b7faafc-4bd9-407f-ae87-8cfbd6237e51","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: ACLY"},{"source_artifact_id":"hypothesis-h-0e0cc0c1","link_type":"related","strength":0.6102000000000001,"evidence":"Reverse: Mechanism wiki 'ACLY Inhibition Rescues Alpha-Synuclein Autophagy' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-072b2f5d","link_type":"related","strength":0.5940000000000001,"evidence":"Reverse: Mechanism wiki 'ACLY Inhibition Rescues Alpha-Synuclein Autophagy' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-74777459","link_type":"related","strength":0.5877,"evidence":"Reverse: Mechanism wiki 'ACLY Inhibition Rescues Alpha-Synuclein Autophagy' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'ACLY Inhibition Rescues Alpha-Synuclein Autophagy' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-69919c49","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-69d383ea","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-7e846ceb","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ae1b2beb","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-38292315","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-82922df8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-a9571dbb","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-b7898b79","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6c83282d","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-73e29e3a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-8fe389e8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"wiki-mechanisms-hif-signaling-neurodegeneration","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"source_artifact_id":"wiki-proteins-ubiquitin","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"source_artifact_id":"wiki-genes-lc3","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-pi3k","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-mtor","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-raptor","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-snca","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-cell-types-p2x3-receptor-neurons","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-technologies-p300-bci","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-models-a53t-alpha-synuclein-mouse-parkinsons","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-proteins-lamp1","link_type":"see_also","strength":0.6,"evidence":"KG edge: inhibits"},{"source_artifact_id":"wiki-proteins-lamp2","link_type":"see_also","strength":0.6,"evidence":"KG edge: inhibits"},{"source_artifact_id":"wiki-proteins-lc3","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-genes-lamp1","link_type":"see_also","strength":0.6,"evidence":"KG edge: inhibits"},{"source_artifact_id":"wiki-genes-lamp2","link_type":"see_also","strength":0.6,"evidence":"KG edge: inhibits"},{"source_artifact_id":"wiki-genes-vhl","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"source_artifact_id":"wiki-investment-ups-therapeutics","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"source_artifact_id":"wiki-mechanisms-cbs-ubiquitin-proteasome-dysfunction","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"source_artifact_id":"wiki-mechanisms-ups-dysfunction-4r-tauopathies","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"source_artifact_id":"wiki-companies-pd-ubiquitin-proteasome-system-therapeutic-companies","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"source_artifact_id":"hypothesis-h-51e7234f","link_type":"related","strength":0.4,"evidence":"KG bridge: ACLY ↔ MTOR"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-002","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-mechanisms-acly-alpha-synuclein-autophagy","is_canonical":true,"supersede_chain":["wiki-mechanisms-acly-alpha-synuclein-autophagy"]}