{"artifact":{"id":"wiki-mechanisms-alpha-synuclein-prion-like-propagation-dlb","artifact_type":"wiki_page","entity_ids":"[\"mechanisms-alpha-synuclein-prion-like-propagation-dlb\"]","title":"Alpha-Synuclein Prion-Like Propagation in DLB","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"6958b761fd62c9ca58e766f42889e17ad54a0a40b76d1c6954c14735df08cc31","metadata":{"slug":"mechanisms-alpha-synuclein-prion-like-propagation-dlb","kg_node_id":null,"entity_type":"mechanism","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-6cd8360e8a14","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"mechanisms-alpha-synuclein-prion-like-propagation-dlb"},"_schema_version":1},"created_at":"2026-04-02T07:20:03-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"1f35190d-3e17-4b85-8d64-9e13ac340c35","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"hypothesis-h-4113b0e8","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Propagation'"},{"target_artifact_id":"hypothesis-h-6c83282d","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Synuclein'"},{"target_artifact_id":"hypothesis-h-74777459","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Synuclein'"},{"target_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Prion'"},{"target_artifact_id":"analysis-sda-2026-04-01-002","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'alpha'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'prion'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-tau-copathology","link_type":"mentions","strength":0.6,"evidence":"Target: DLB"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-treatment-response-biomarkers","link_type":"mentions","strength":0.6,"evidence":"Target: DLB"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-alpha-synuclein-staging-spreading","link_type":"mentions","strength":0.6,"evidence":"Target: DLB"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-cognitive-fluctuation-mechanism","link_type":"mentions","strength":0.5,"evidence":null},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-cholinergic-dysfunction-mechanisms","link_type":"mentions","strength":0.5,"evidence":null},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-genetic-modifiers","link_type":"mentions","strength":0.5,"evidence":null},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-tau-copathology","link_type":"related","strength":0.7,"evidence":"Wiki page for DLB related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-treatment-response-biomarkers","link_type":"related","strength":0.7,"evidence":"Wiki page for DLB related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-alpha-synuclein-staging-spreading","link_type":"related","strength":0.7,"evidence":"Wiki page for DLB related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-cognitive-fluctuation-mechanism","link_type":"related","strength":0.7,"evidence":"Wiki page for DLB related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-cholinergic-dysfunction-mechanisms","link_type":"related","strength":0.7,"evidence":"Wiki page for DLB related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-genetic-modifiers","link_type":"related","strength":0.7,"evidence":"Wiki page for DLB related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"wiki-institutions-alzheimer-indonesia","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-institutions-dementia-australia","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-entities-microglia-in-neurodegeneration","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"wiki-circuits-parkinson-basal-ganglia-circuit","link_type":"see_also","strength":0.6,"evidence":"KG edge: co_discussed"},{"target_artifact_id":"hypothesis-h-4113b0e8","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-74777459","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Alpha-synuclein aggregation / synaptic vesicle"},{"target_artifact_id":"hypothesis-h-8b7727c1","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Bacterial curli amyloid → α-synuclein cross-seeding (gut-brain axis)"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-8b7727c1","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Bacterial curli amyloid → α-synuclein cross-seeding (gut-brain axis)"},{"source_artifact_id":"experiment-exp-wiki-experiments-dlb-tau-copathology","link_type":"related","strength":0.54,"evidence":"Reverse: Target: DLB"},{"source_artifact_id":"experiment-exp-wiki-experiments-dlb-treatment-response-biomarkers","link_type":"related","strength":0.54,"evidence":"Reverse: Target: DLB"},{"source_artifact_id":"experiment-exp-wiki-experiments-dlb-alpha-synuclein-staging-spreading","link_type":"related","strength":0.54,"evidence":"Reverse: Target: DLB"},{"source_artifact_id":"experiment-exp-wiki-experiments-dlb-cognitive-fluctuation-mechanism","link_type":"related","strength":0.7,"evidence":"Experiment targets DLB described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-dlb-cholinergic-dysfunction-mechanisms","link_type":"related","strength":0.7,"evidence":"Experiment targets DLB described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-dlb-genetic-modifiers","link_type":"related","strength":0.7,"evidence":"Experiment targets DLB described in wiki"},{"source_artifact_id":"hypothesis-h-4113b0e8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6c83282d","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-74777459","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-002","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-mechanisms-alpha-synuclein-prion-like-propagation-dlb","is_canonical":true,"supersede_chain":["wiki-mechanisms-alpha-synuclein-prion-like-propagation-dlb"]}