{"artifact":{"id":"wiki-mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain","artifact_type":"wiki_page","entity_ids":"[\"mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain\"]","title":"APOE Lipid Dysregulation Causal Chain in AD","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"9ea336d600c7eb6e055bc26ef99dc5a042c9b9836ce8fe297b7980489785c292","metadata":{"slug":"mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain","kg_node_id":null,"entity_type":"mechanism","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-1052f130852d","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain"},"_schema_version":1},"created_at":"2026-04-02T07:20:01-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"61e08da8-540b-42b7-bf1e-1cb150f2c5cf","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-mechanisms-apoe4-alzheimers","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"analysis-SDA-2026-04-04-frontier-lipidomics-dcdbc360","link_type":"mentions","strength":0.75,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-6b555d09-fc9c-4209-a344-84301cc2ab55","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-d003e659-7083-433b-b1e8-b68107d462b1","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"target_artifact_id":"experiment-exp-9d2d59a7-8bc0-4399-aab0-2538f3a07b6f","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"target_artifact_id":"experiment-exp-5a6f4c79-3293-4bc0-98f5-194619bfd1b9","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-792473c3-ae88-48b9-9be1-bb38969946ee","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-12e37301-cace-448f-a5e5-d03822faf9ef","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-a6d16514-1a7a-45c3-8ca8-df341e213c0a","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-2267dce9-5cf9-4e2f-a543-e339e9156522","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"target_artifact_id":"experiment-exp-5f260106-156f-4a2c-81f6-c5bcda91b514","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-3b7faafc-4bd9-407f-ae87-8cfbd6237e51","link_type":"mentions","strength":0.5,"evidence":"Content: APOE4 mentioned 30x in wiki/mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain"},{"target_artifact_id":"experiment-exp-cd057ef1-be07-4231-8dd0-c1a6f5d83839","link_type":"mentions","strength":0.5,"evidence":"Content: ABCA1 mentioned 7x in wiki/mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain"},{"target_artifact_id":"experiment-exp-03a934e0-f1ad-47aa-9dcd-9cf748477080","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSD95 mentioned 2x in wiki/mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain"},{"target_artifact_id":"experiment-exp-fbeb6f18-af7c-47f2-b446-1d698212c3db","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"hypothesis-h-b948c32c","link_type":"mentions","strength":0.657,"evidence":"Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.672,"evidence":"Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.631,"evidence":"Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.675,"evidence":"Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-1acdd55e","link_type":"mentions","strength":0.668,"evidence":"Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-9d29bfe5","link_type":"mentions","strength":0.704,"evidence":"Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.7,"evidence":"Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.6,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-sex-differences-alzheimers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-metal-ion-homeostasis-alzheimers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-sleep-circadian-neurodegeneration-mechanism","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-neural-stem-cell-therapy-alzheimers-disease","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-tbi-impact-profiles-cte-phenotype-heterogeneity","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-genetic-modifiers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-microglial-aging-immune-memory","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"hypothesis-h-7d4a24d3","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Lipid'"},{"target_artifact_id":"hypothesis-h-3d993b5d","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Lipid'"},{"target_artifact_id":"hypothesis-h-807d7a82","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Dysregulation'"},{"target_artifact_id":"hypothesis-h-7957bb2a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Lipid'"},{"target_artifact_id":"hypothesis-h-bb518928","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Lipid'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'lipid'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'dysregulation'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'lipid'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-amyloid-resilient-phenotype","link_type":"mentions","strength":0.5,"evidence":"Content: APOE mentioned 25x in wiki/mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-combination-therapy-trial","link_type":"mentions","strength":0.5,"evidence":"Content: APOE mentioned 25x in wiki/mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 9x in wiki/mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 9x in wiki/mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 9x in wiki/mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"mentions","strength":0.7,"evidence":"Gene match: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-biomarker-guided-therapy-sequencing-ad","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-ad-detection","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-oligodendrocyte-myelin-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-amyloid-resilient-phenotype","link_type":"related","strength":0.7,"evidence":"Wiki page for APOE related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-neural-oscillation-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-proteasome-ubiquitin-system-dysfunction-parkinso","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-sex-differences-alzheimers","link_type":"related","strength":0.7,"evidence":"Wiki page for APOE related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-microbiome-alpha-synuclein-propagation","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-stress-granule-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-animal-model-comparison-neurodegeneration","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-combination-therapy-trial","link_type":"related","strength":0.7,"evidence":"Wiki page for APOE related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-biomarker-guided-therapy-sequencing-ad","link_type":"related","strength":0.7,"evidence":"Wiki page for APOE related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-protein-aggregation-kinetic-validation","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-ad-detection","link_type":"related","strength":0.7,"evidence":"Wiki page for APOE related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-tht-validation-protein-aggregation","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-endocannabinoid-system-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-glymphatic-circadian-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-regulated-necrosis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-metal-ion-homeostasis-alzheimers","link_type":"related","strength":0.7,"evidence":"Wiki page for APOE related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-purinergic-signaling-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"mentions","strength":0.6,"evidence":"Entity name match: APOE"},{"target_artifact_id":"hypothesis-h-15336069","link_type":"mentions","strength":0.6,"evidence":"Entity name match: APOE"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TREM2'"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TREM2'"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TREM2'"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TREM2'"},{"target_artifact_id":"hypothesis-h-7d4a24d3","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-3d993b5d","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-807d7a82","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-7957bb2a","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-bb518928","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-0e675a41","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-a8165b3b","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-5d943bfc","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-58e655ee","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-15336069","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-6657f7cd","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Sphingolipid metabolism"},{"target_artifact_id":"hypothesis-h-b948c32c","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-9d29bfe5","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Cholesterol efflux / lipid transport"},{"target_artifact_id":"hypothesis-h-12599989","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Sphingolipid / ceramide signaling"},{"target_artifact_id":"hypothesis-h-fdb07848","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Sphingolipid / ceramide signaling"},{"target_artifact_id":"hypothesis-h-a015e80e","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Lipid raft membrane organization"},{"target_artifact_id":"hypothesis-h-3d545f4e","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: APOE-TREM2 lipid sensing / microglial phagocytosis axis"},{"target_artifact_id":"experiment-exp-wiki-experiments-vascular-contribution-alzheimers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-vascular-contributions-mixed-dementia","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-tbi-alzheimers-mechanism","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-viral-infection-alzheimers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-glp1-responder-prediction-pd","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-treatment-response-biomarkers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-brain-connectivity-tacs-early-ad","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-cholinergic-dysfunction-mechanisms","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-apoe4-function-alzheimers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-normal-aging-to-ad-transition","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-experiments-down-syndrome-alzheimers-mechanisms-timing","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-wiki-diseases-tbi-impact-profiles-cte-phenotype-heterogeneity","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-debate-0a5edc59c7b9","link_type":"mentions","strength":0.7,"evidence":"Gene mention: APOE"},{"target_artifact_id":"experiment-exp-e211ffa3-de74-4b6e-bfc6-c31762ebe5dc","link_type":"mentions","strength":0.8,"evidence":"Gene target: APOE"},{"target_artifact_id":"wiki-mechanisms-apoe-lipid-metabolism-alzheimers","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-endolysosomal-pathway-alzheimers","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"analysis-astrocyte-subtypes","link_type":"mentions","strength":0.75,"evidence":"Gene mention: APOE"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"}],"incoming_links":[{"source_artifact_id":"wiki-mechanisms-apoe4-alzheimers","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"hypothesis-h-c9c79e3e","link_type":"related","strength":0.54,"evidence":"Reverse: Entity name match: APOE"},{"source_artifact_id":"hypothesis-h-15336069","link_type":"related","strength":0.54,"evidence":"Reverse: Entity name match: APOE"},{"source_artifact_id":"hypothesis-h-6657f7cd","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Sphingolipid metabolism"},{"source_artifact_id":"hypothesis-h-12599989","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Sphingolipid / ceramide signaling"},{"source_artifact_id":"hypothesis-h-fdb07848","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Sphingolipid / ceramide signaling"},{"source_artifact_id":"hypothesis-h-a015e80e","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Lipid raft membrane organization"},{"source_artifact_id":"hypothesis-h-3d545f4e","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"hypothesis-h-180807e5","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: APOE-TREM2 lipid sensing / microglial phagocytosis axis"},{"source_artifact_id":"experiment-exp-wiki-experiments-vascular-contribution-alzheimers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-vascular-contributions-mixed-dementia","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-tbi-alzheimers-mechanism","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-viral-infection-alzheimers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-glp1-responder-prediction-pd","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-dlb-treatment-response-biomarkers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-brain-connectivity-tacs-early-ad","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-dlb-cholinergic-dysfunction-mechanisms","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-apoe4-function-alzheimers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-normal-aging-to-ad-transition","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-down-syndrome-alzheimers-mechanisms-timing","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-diseases-tbi-impact-profiles-cte-phenotype-heterogeneity","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-debate-0a5edc59c7b9","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-e211ffa3-de74-4b6e-bfc6-c31762ebe5dc","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"source_artifact_id":"analysis-SDA-2026-04-04-frontier-lipidomics-dcdbc360","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-6b555d09-fc9c-4209-a344-84301cc2ab55","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-d003e659-7083-433b-b1e8-b68107d462b1","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"source_artifact_id":"experiment-exp-9d2d59a7-8bc0-4399-aab0-2538f3a07b6f","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"source_artifact_id":"experiment-exp-5a6f4c79-3293-4bc0-98f5-194619bfd1b9","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-792473c3-ae88-48b9-9be1-bb38969946ee","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-12e37301-cace-448f-a5e5-d03822faf9ef","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-a6d16514-1a7a-45c3-8ca8-df341e213c0a","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-2267dce9-5cf9-4e2f-a543-e339e9156522","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: APOE"},{"source_artifact_id":"experiment-exp-5f260106-156f-4a2c-81f6-c5bcda91b514","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-fbeb6f18-af7c-47f2-b446-1d698212c3db","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.8,"evidence":"Hypothesis involves entity 'APOE' with wiki page"},{"source_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.8,"evidence":"Hypothesis involves entity 'APOE' with wiki page"},{"source_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.8,"evidence":"Hypothesis involves entity 'APOE' with wiki page"},{"source_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.8,"evidence":"Hypothesis involves entity 'APOE' with wiki page"},{"source_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.8,"evidence":"Hypothesis involves entity 'APOE' with wiki page"},{"source_artifact_id":"hypothesis-h-b948c32c","link_type":"related","strength":0.5913,"evidence":"Reverse: Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":0.6048,"evidence":"Reverse: Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-d0a564e8","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.5679000000000001,"evidence":"Reverse: Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.6075,"evidence":"Reverse: Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-1acdd55e","link_type":"related","strength":0.6012000000000001,"evidence":"Reverse: Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-9d29bfe5","link_type":"related","strength":0.6335999999999999,"evidence":"Reverse: Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.63,"evidence":"Reverse: Mechanism wiki 'APOE Lipid Dysregulation Causal Chain in AD' references gene/pathway from hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-sex-differences-alzheimers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-metal-ion-homeostasis-alzheimers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-sleep-circadian-neurodegeneration-mechanism","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-neural-stem-cell-therapy-alzheimers-disease","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-tbi-impact-profiles-cte-phenotype-heterogeneity","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-dlb-genetic-modifiers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"experiment-exp-wiki-experiments-microglial-aging-immune-memory","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene APOE described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-oligodendrocyte-myelin-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-ad-amyloid-resilient-phenotype","link_type":"related","strength":0.7,"evidence":"Experiment targets APOE described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-neural-oscillation-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-proteasome-ubiquitin-system-dysfunction-parkinso","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-microbiome-alpha-synuclein-propagation","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-stress-granule-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-animal-model-comparison-neurodegeneration","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-ad-combination-therapy-trial","link_type":"related","strength":0.7,"evidence":"Experiment targets APOE described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-biomarker-guided-therapy-sequencing-ad","link_type":"related","strength":0.7,"evidence":"Experiment targets APOE described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-protein-aggregation-kinetic-validation","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-ad-detection","link_type":"related","strength":0.7,"evidence":"Experiment targets APOE described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-tht-validation-protein-aggregation","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-endocannabinoid-system-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-glymphatic-circadian-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-regulated-necrosis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-purinergic-signaling-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"hypothesis-h-7d4a24d3","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-3d993b5d","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-807d7a82","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-7957bb2a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-bb518928","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"wiki-mechanisms-apoe-lipid-metabolism-alzheimers","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-endolysosomal-pathway-alzheimers","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"analysis-astrocyte-subtypes","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: APOE"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain","is_canonical":true,"supersede_chain":["wiki-mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain"]}