{"artifact":{"id":"wiki-mechanisms-bbb-dysfunction-comparison-ad-pd-als","artifact_type":"wiki_page","entity_ids":"[\"mechanisms-bbb-dysfunction-comparison-ad-pd-als\"]","title":"Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"0948b96192e99bcaec5c669c4ff9cc9d6710b860a72b19eb631b878032199583","metadata":{"slug":"mechanisms-bbb-dysfunction-comparison-ad-pd-als","kg_node_id":null,"entity_type":"mechanism","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-ef38592fa573","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"mechanisms-bbb-dysfunction-comparison-ad-pd-als"},"_schema_version":1},"created_at":"2026-04-02T07:19:58-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"c3d950e8-e4fa-4012-bdb6-4c0c84ee7b7a","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"analysis-SDA-2026-04-04-gap-senescent-clearance-neuro","link_type":"mentions","strength":0.6,"evidence":"Gene mention: BBB"},{"target_artifact_id":"analysis-SDA-2026-04-12-gap-debate-20260410-112908-13c403ee","link_type":"mentions","strength":0.6,"evidence":"Gene mention: BBB"},{"target_artifact_id":"analysis-SDA-2026-04-08-gap-pubmed-20260406-062212-b66510d9","link_type":"mentions","strength":0.6,"evidence":"Gene mention: ALS"},{"target_artifact_id":"analysis-SDA-2026-04-13-gap-20260410-172514","link_type":"mentions","strength":0.6,"evidence":"Gene mention: ALS"},{"target_artifact_id":"hypothesis-h-7e846ceb","link_type":"mentions","strength":0.659,"evidence":"Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-84808267","link_type":"mentions","strength":0.694,"evidence":"Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-7e0b5ade","link_type":"mentions","strength":0.66,"evidence":"Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-b948c32c","link_type":"mentions","strength":0.657,"evidence":"Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.672,"evidence":"Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.631,"evidence":"Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.675,"evidence":"Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-4fabd9ce","link_type":"mentions","strength":0.675,"evidence":"Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-eea667a9","link_type":"mentions","strength":0.667,"evidence":"Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-4dd0d19b","link_type":"mentions","strength":0.718,"evidence":"Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.7,"evidence":"Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-microglial-subtypes-20260402004119","link_type":"mentions","strength":0.6,"evidence":"Gene mention: ALS"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.6,"evidence":"Gene mention: ALS"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.6,"evidence":"Gene mention: ALS"},{"target_artifact_id":"hypothesis-h-959a4677","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Blood'"},{"target_artifact_id":"hypothesis-h-6c83282d","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Barrier'"},{"target_artifact_id":"analysis-sda-2026-04-01-003","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'dysfunction'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'dysfunction'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'Brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'Brain'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"mentions","strength":0.6,"evidence":"Gene mention: ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-pet-therapeutic-response-prediction","link_type":"mentions","strength":0.5,"evidence":"Content: LRP1 mentioned 7x in wiki/mechanisms-bbb-dysfunction-comparison-ad-pd-als"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-propagation-causality","link_type":"mentions","strength":0.5,"evidence":"Content: LRP1 mentioned 7x in wiki/mechanisms-bbb-dysfunction-comparison-ad-pd-als"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-immunotherapy-dosing","link_type":"mentions","strength":0.5,"evidence":"Content: LRP1 mentioned 7x in wiki/mechanisms-bbb-dysfunction-comparison-ad-pd-als"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-amyloid-resilient-phenotype","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: APOE mentioned 2x in wiki/mechanisms-bbb-dysfunction-comparison-ad-pd-als"},{"target_artifact_id":"experiment-exp-wiki-experiments-sex-differences-alzheimers","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: APOE mentioned 2x in wiki/mechanisms-bbb-dysfunction-comparison-ad-pd-als"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-combination-therapy-trial","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: APOE mentioned 2x in wiki/mechanisms-bbb-dysfunction-comparison-ad-pd-als"},{"target_artifact_id":"experiment-exp-wiki-experiments-lrrk2-gba-carrier-resilience-pd","link_type":"mentions","strength":0.5,"evidence":"Content: LRRK2 mentioned 4x in wiki/mechanisms-bbb-dysfunction-comparison-ad-pd-als"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: TREM2 mentioned 2x in wiki/mechanisms-bbb-dysfunction-comparison-ad-pd-als"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: TREM2 mentioned 2x in wiki/mechanisms-bbb-dysfunction-comparison-ad-pd-als"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: TREM2 mentioned 2x in wiki/mechanisms-bbb-dysfunction-comparison-ad-pd-als"},{"target_artifact_id":"experiment-exp-wiki-experiments-c9orf72-hexanucleotide-repeat-mechanism","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-als-sporadic-initiation-biology","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-n-of-1-clinical-trial-cbs-psp","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-microbiome-gut-barrier-als","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-brainstem-circuit-modulation-psp","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-prion-pre-symptomatic-detection","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-sleep-respiratory-als","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-progranulin-tdp43-mechanism-ftd","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-environmental-exposure-als","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-progranulin-replacement-therapy-ftd","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-als-progression-rate-heterogeneity","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-viral-post-infectious-als-mechanism","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-tdp43-pet-ligand-development","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-fxtas-penetrance-modifiers","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-pre-symptomatic-tau-detection-mapt","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-als-regional-onset-spread","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-c9orf72-phenotype-divergence-als-ftd","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-als-metabolic-therapeutic-targeting","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-vs-tau-pet-monitoring","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for CT related to experiment"},{"target_artifact_id":"experiment-exp-debate-d1ef3eb9ecab","link_type":"related","strength":0.6,"evidence":"Wiki disease page related to experiment about ALS"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'APOE'"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'APOE'"},{"target_artifact_id":"hypothesis-h-15336069","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'APOE'"},{"target_artifact_id":"hypothesis-h-seaad-v4-5a7a4079","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-e3e8407c","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-075f1f02","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-aa2d317c","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Blood-brain barrier transport"},{"target_artifact_id":"hypothesis-h-73e4340b","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Blood-brain barrier transport"},{"target_artifact_id":"hypothesis-h-6c83282d","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Gut-brain axis / microbiome signaling"},{"target_artifact_id":"hypothesis-h-2600483e","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Cholesterol 24-hydroxylase / brain cholesterol turnover"},{"target_artifact_id":"hypothesis-h-a87702b6","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Brain cholesterol homeostasis (HMGCR synthesis → CYP46A1 elimination)"},{"target_artifact_id":"hypothesis-h-8b7727c1","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Bacterial curli amyloid → α-synuclein cross-seeding (gut-brain axis)"},{"target_artifact_id":"hypothesis-h-7693c291","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TARDBP"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-7a8d7379","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: Claudin-5"},{"target_artifact_id":"analysis-SDA-2026-04-03-gap-crispr-neurodegeneration-20260402","link_type":"mentions","strength":0.6,"evidence":"Gene mention: ALS"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-006","link_type":"mentions","strength":0.6,"evidence":"Gene mention: ALS"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.6,"evidence":"Gene mention: ALS"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'brain'"}],"incoming_links":[{"source_artifact_id":"experiment-exp-wiki-experiments-c9orf72-hexanucleotide-repeat-mechanism","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-als-sporadic-initiation-biology","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-n-of-1-clinical-trial-cbs-psp","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-microbiome-gut-barrier-als","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-brainstem-circuit-modulation-psp","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-prion-pre-symptomatic-detection","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-sleep-respiratory-als","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-progranulin-tdp43-mechanism-ftd","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-environmental-exposure-als","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-progranulin-replacement-therapy-ftd","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-als-progression-rate-heterogeneity","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-viral-post-infectious-als-mechanism","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-tdp43-pet-ligand-development","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-fxtas-penetrance-modifiers","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-pre-symptomatic-tau-detection-mapt","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-als-regional-onset-spread","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-c9orf72-phenotype-divergence-als-ftd","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-als-metabolic-therapeutic-targeting","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-vs-tau-pet-monitoring","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-006","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: ALS"},{"source_artifact_id":"experiment-exp-debate-d1ef3eb9ecab","link_type":"related","strength":0.54,"evidence":"Reverse: Wiki disease page related to experiment about ALS"},{"source_artifact_id":"hypothesis-h-aa2d317c","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Blood-brain barrier transport"},{"source_artifact_id":"hypothesis-h-73e4340b","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Blood-brain barrier transport"},{"source_artifact_id":"hypothesis-h-2600483e","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Cholesterol 24-hydroxylase / brain cholesterol turnover"},{"source_artifact_id":"hypothesis-h-a87702b6","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Brain cholesterol homeostasis (HMGCR synthesis → CYP46A1 elimination)"},{"source_artifact_id":"hypothesis-h-8b7727c1","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Bacterial curli amyloid → α-synuclein cross-seeding (gut-brain axis)"},{"source_artifact_id":"analysis-SDA-2026-04-03-gap-crispr-neurodegeneration-20260402","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: ALS"},{"source_artifact_id":"analysis-SDA-2026-04-04-gap-senescent-clearance-neuro","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"analysis-SDA-2026-04-12-gap-debate-20260410-112908-13c403ee","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: BBB"},{"source_artifact_id":"analysis-SDA-2026-04-08-gap-pubmed-20260406-062212-b66510d9","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: ALS"},{"source_artifact_id":"analysis-SDA-2026-04-13-gap-20260410-172514","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: ALS"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-microglial-subtypes-20260402004119","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: ALS"},{"source_artifact_id":"hypothesis-h-7e846ceb","link_type":"related","strength":0.5931000000000001,"evidence":"Reverse: Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-84808267","link_type":"related","strength":0.6245999999999999,"evidence":"Reverse: Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-7e0b5ade","link_type":"related","strength":0.5940000000000001,"evidence":"Reverse: Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-b948c32c","link_type":"related","strength":0.5913,"evidence":"Reverse: Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":0.6048,"evidence":"Reverse: Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-d0a564e8","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.5679000000000001,"evidence":"Reverse: Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.6075,"evidence":"Reverse: Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-4fabd9ce","link_type":"related","strength":0.6075,"evidence":"Reverse: Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-eea667a9","link_type":"related","strength":0.6003000000000001,"evidence":"Reverse: Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-4dd0d19b","link_type":"related","strength":0.6462,"evidence":"Reverse: Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.63,"evidence":"Reverse: Mechanism wiki 'Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: ALS"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: ALS"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: ALS"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets CT described in wiki"},{"source_artifact_id":"hypothesis-h-959a4677","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6c83282d","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-003","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-mechanisms-bbb-dysfunction-comparison-ad-pd-als","is_canonical":true,"supersede_chain":["wiki-mechanisms-bbb-dysfunction-comparison-ad-pd-als"]}