{"artifact":{"id":"wiki-mechanisms-cbs-psp-genetic-architecture","artifact_type":"wiki_page","entity_ids":"[\"mechanisms-cbs-psp-genetic-architecture\"]","title":"CBS/PSP Genetic Architecture","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"e11d43ffa0f0222811b70573e355a2c2ff6755e0d849adcba9c3e123d61d1fcd","metadata":{"slug":"mechanisms-cbs-psp-genetic-architecture","kg_node_id":null,"entity_type":"mechanism","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-d573e6fb0813","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"mechanisms-cbs-psp-genetic-architecture"},"_schema_version":1},"created_at":"2026-04-02T07:19:52-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"7e271eb5-24dc-4611-9a80-a8ca271a8f42","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-32576dcf-a6c7-4ff9-b7b8-37903a89693e","link_type":"mentions","strength":0.5,"evidence":"Content: MAPT mentioned 36x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"experiment-exp-65257309-482b-4700-8d80-284109e46653","link_type":"mentions","strength":0.5,"evidence":"Content: MAPT mentioned 36x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"experiment-exp-db3f412b-7d9b-493e-a89c-ca2db30ee400","link_type":"mentions","strength":0.5,"evidence":"Content: RUNX2 mentioned 3x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"hypothesis-h-2a4e4ad2","link_type":"mentions","strength":0.6,"evidence":"Content: BNIP3 mentioned 4x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"experiment-exp-546a7e07-4a45-4e78-b0f9-50f2f2fd7e05","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SNCA mentioned 2x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"experiment-exp-2e59e044-73e6-418e-9728-5c3a30daa75e","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SNCA mentioned 2x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"experiment-exp-cd85e950-e169-432f-a651-510fdde03f01","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SNCA mentioned 2x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"hypothesis-h-b948c32c","link_type":"mentions","strength":0.657,"evidence":"Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.672,"evidence":"Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.631,"evidence":"Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.675,"evidence":"Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-072b2f5d","link_type":"mentions","strength":0.66,"evidence":"Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-e7e1f943","link_type":"mentions","strength":0.696,"evidence":"Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-74777459","link_type":"mentions","strength":0.653,"evidence":"Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.7,"evidence":"Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"mentions","strength":0.657,"evidence":"Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.6,"evidence":"Gene mention: PSP"},{"target_artifact_id":"experiment-exp-wiki-experiments-n-of-1-clinical-trial-cbs-psp","link_type":"mentions","strength":0.8,"evidence":"Gene target: CBS"},{"target_artifact_id":"experiment-exp-wiki-experiments-4r-tau-targeting-psp-cbs","link_type":"mentions","strength":0.7,"evidence":"Gene mention: CBS"},{"target_artifact_id":"experiment-exp-wiki-experiments-cbs-psp-phenotype-determinants","link_type":"mentions","strength":0.8,"evidence":"Gene target: CBS"},{"target_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"mentions","strength":0.7,"evidence":"Gene mention: CBS"},{"target_artifact_id":"experiment-exp-wiki-experiments-crispr-gene-correction-cbs-psp","link_type":"mentions","strength":0.7,"evidence":"Gene mention: CBS"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"experiment-exp-wiki-experiments-multi-ethnic-pd-gwas","link_type":"mentions","strength":0.5,"evidence":"Content: GWAS mentioned 15x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"experiment-exp-wiki-experiments-pre-symptomatic-tau-detection-mapt","link_type":"mentions","strength":0.5,"evidence":"Content: MAPT mentioned 36x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"experiment-exp-wiki-experiments-lrrk2-gba-carrier-resilience-pd","link_type":"mentions","strength":0.5,"evidence":"Content: LRRK2 mentioned 11x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-amyloid-resilient-phenotype","link_type":"mentions","strength":0.5,"evidence":"Content: APOE mentioned 11x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"experiment-exp-wiki-experiments-sex-differences-alzheimers","link_type":"mentions","strength":0.5,"evidence":"Content: APOE mentioned 11x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-combination-therapy-trial","link_type":"mentions","strength":0.5,"evidence":"Content: APOE mentioned 11x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: TREM2 mentioned 2x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: TREM2 mentioned 2x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: TREM2 mentioned 2x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"target_artifact_id":"experiment-exp-wiki-experiments-n-of-1-clinical-trial-cbs-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for CBS related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-brainstem-circuit-modulation-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-spreading-network-mapping-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-4r-tau-targeting-psp-cbs","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-levodopa-response-psp-biomarkers","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-cbs-psp-phenotype-determinants","link_type":"related","strength":0.7,"evidence":"Wiki page for CBS related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-pathology-initiation-zone","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"related","strength":0.7,"evidence":"Wiki page for PSP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for CT related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'APOE'"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'APOE'"},{"target_artifact_id":"hypothesis-h-15336069","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'APOE'"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-881362dc","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Epigenetic regulation"},{"target_artifact_id":"hypothesis-h-782e55f6","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Epigenetic regulation"},{"target_artifact_id":"hypothesis-h-19003961","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Arginine methylation / epigenetic regulation"},{"target_artifact_id":"hypothesis-h-d2722680","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Epigenetic regulation"},{"target_artifact_id":"hypothesis-h-e3506e5a","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Synthetic biology / chemogenetics"},{"target_artifact_id":"hypothesis-h-d7121bcc","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Epigenetic regulation"},{"target_artifact_id":"hypothesis-h-addc0a61","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Epigenetic regulation"},{"target_artifact_id":"hypothesis-h-a90e2e89","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Epigenetic regulation"},{"target_artifact_id":"hypothesis-h-baba5269","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Epigenetic regulation"},{"target_artifact_id":"hypothesis-h-29ef94d5","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CREB/BDNF epigenetic regulation of synaptic plasticity"},{"target_artifact_id":"hypothesis-h-9d22b570","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"target_artifact_id":"hypothesis-h-826df660","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Optogenetic calcium signaling → mitochondrial fission/transfer"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-8fe389e8","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene HDAC"},{"target_artifact_id":"hypothesis-h-c8ccbee8","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: glymphatic clearance"},{"target_artifact_id":"hypothesis-h-62e56eb9","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: glymphatic clearance"},{"target_artifact_id":"hypothesis-h-807d7a82","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: glymphatic clearance"},{"target_artifact_id":"hypothesis-h-83efeed6","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: glymphatic clearance"},{"target_artifact_id":"hypothesis-h-9e9fee95","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: glymphatic clearance"},{"target_artifact_id":"hypothesis-h-de579caf","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: glymphatic clearance"},{"target_artifact_id":"experiment-exp-wiki-experiments-als-progression-rate-heterogeneity","link_type":"mentions","strength":0.7,"evidence":"Gene mention: CBS"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-005","link_type":"mentions","strength":0.6,"evidence":"Gene mention: PSP"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-19003961","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Arginine methylation / epigenetic regulation"},{"source_artifact_id":"hypothesis-h-d2722680","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Epigenetic regulation"},{"source_artifact_id":"hypothesis-h-e3506e5a","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Synthetic biology / chemogenetics"},{"source_artifact_id":"hypothesis-h-d7121bcc","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Epigenetic regulation"},{"source_artifact_id":"hypothesis-h-881362dc","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Epigenetic regulation"},{"source_artifact_id":"hypothesis-h-782e55f6","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Epigenetic regulation"},{"source_artifact_id":"hypothesis-h-addc0a61","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Epigenetic regulation"},{"source_artifact_id":"hypothesis-h-a90e2e89","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Epigenetic regulation"},{"source_artifact_id":"hypothesis-h-baba5269","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Epigenetic regulation"},{"source_artifact_id":"hypothesis-h-29ef94d5","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CREB/BDNF epigenetic regulation of synaptic plasticity"},{"source_artifact_id":"hypothesis-h-9d22b570","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CRISPRa epigenetic activation of dopaminergic transcription factor network"},{"source_artifact_id":"hypothesis-h-826df660","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Optogenetic calcium signaling → mitochondrial fission/transfer"},{"source_artifact_id":"experiment-exp-wiki-experiments-als-progression-rate-heterogeneity","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: CBS"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-005","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"hypothesis-h-2a4e4ad2","link_type":"related","strength":0.54,"evidence":"Reverse: Content: BNIP3 mentioned 4x in wiki/mechanisms-cbs-psp-genetic-architecture"},{"source_artifact_id":"hypothesis-h-b948c32c","link_type":"related","strength":0.5913,"evidence":"Reverse: Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":0.6048,"evidence":"Reverse: Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-d0a564e8","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.5679000000000001,"evidence":"Reverse: Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.6075,"evidence":"Reverse: Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-072b2f5d","link_type":"related","strength":0.5940000000000001,"evidence":"Reverse: Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-e7e1f943","link_type":"related","strength":0.6264,"evidence":"Reverse: Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-74777459","link_type":"related","strength":0.5877,"evidence":"Reverse: Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.63,"evidence":"Reverse: Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.5913,"evidence":"Reverse: Mechanism wiki 'CBS/PSP Genetic Architecture' references gene/pathway from hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: PSP"},{"source_artifact_id":"experiment-exp-wiki-experiments-n-of-1-clinical-trial-cbs-psp","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: CBS"},{"source_artifact_id":"experiment-exp-wiki-experiments-4r-tau-targeting-psp-cbs","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: CBS"},{"source_artifact_id":"experiment-exp-wiki-experiments-cbs-psp-phenotype-determinants","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: CBS"},{"source_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: CBS"},{"source_artifact_id":"experiment-exp-wiki-experiments-crispr-gene-correction-cbs-psp","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: CBS"},{"source_artifact_id":"experiment-exp-wiki-experiments-brainstem-circuit-modulation-psp","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-tau-spreading-network-mapping-psp","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-levodopa-response-psp-biomarkers","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-tau-pathology-initiation-zone","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"related","strength":0.7,"evidence":"Experiment targets PSP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets CT described in wiki"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-mechanisms-cbs-psp-genetic-architecture","is_canonical":true,"supersede_chain":["wiki-mechanisms-cbs-psp-genetic-architecture"]}