{"artifact":{"id":"wiki-mechanisms-exosome-mediated-propagation","artifact_type":"wiki_page","entity_ids":"[\"mechanisms-exosome-mediated-propagation\"]","title":"Exosome-Mediated Pathological Protein Propagation","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"16360a246b1f6e6e9afcf7e055a4968d010b01b816946f1c29d8b5063e128d4f","metadata":{"slug":"mechanisms-exosome-mediated-propagation","kg_node_id":null,"entity_type":"mechanism","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-ad8a265488b5","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"mechanisms-exosome-mediated-propagation"},"_schema_version":1},"created_at":"2026-04-02T07:19:57-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"576447d9-b63e-4128-9e14-78ec8fbb11f0","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-546a7e07-4a45-4e78-b0f9-50f2f2fd7e05","link_type":"mentions","strength":0.5,"evidence":"Content: SNCA mentioned 3x in wiki/mechanisms-exosome-mediated-propagation"},{"target_artifact_id":"experiment-exp-2e59e044-73e6-418e-9728-5c3a30daa75e","link_type":"mentions","strength":0.5,"evidence":"Content: SNCA mentioned 3x in wiki/mechanisms-exosome-mediated-propagation"},{"target_artifact_id":"experiment-exp-cd85e950-e169-432f-a651-510fdde03f01","link_type":"mentions","strength":0.5,"evidence":"Content: SNCA mentioned 3x in wiki/mechanisms-exosome-mediated-propagation"},{"target_artifact_id":"experiment-exp-32576dcf-a6c7-4ff9-b7b8-37903a89693e","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: MAPT mentioned 2x in wiki/mechanisms-exosome-mediated-propagation"},{"target_artifact_id":"experiment-exp-65257309-482b-4700-8d80-284109e46653","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: MAPT mentioned 2x in wiki/mechanisms-exosome-mediated-propagation"},{"target_artifact_id":"hypothesis-h-7e846ceb","link_type":"mentions","strength":0.659,"evidence":"Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-b948c32c","link_type":"mentions","strength":0.657,"evidence":"Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.672,"evidence":"Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.631,"evidence":"Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.675,"evidence":"Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-072b2f5d","link_type":"mentions","strength":0.66,"evidence":"Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-4fabd9ce","link_type":"mentions","strength":0.675,"evidence":"Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-eea667a9","link_type":"mentions","strength":0.667,"evidence":"Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-74777459","link_type":"mentions","strength":0.653,"evidence":"Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-d2df6eaf","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-d40d2659","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Protein'"},{"target_artifact_id":"hypothesis-h-dca3e907","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Protein'"},{"target_artifact_id":"hypothesis-h-637a53c9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-58e4635a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-1acdd55e","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-6ce4884a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'mediated'"},{"target_artifact_id":"hypothesis-h-d7121bcc","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-881362dc","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-4113b0e8","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Propagation'"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'mediated'"},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'pathological'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'protein'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mediated'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"experiment-exp-wiki-experiments-pre-symptomatic-tau-detection-mapt","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: MAPT mentioned 2x in wiki/mechanisms-exosome-mediated-propagation"},{"target_artifact_id":"experiment-exp-wiki-experiments-environmental-exposure-als","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: TARDBP mentioned 2x in wiki/mechanisms-exosome-mediated-propagation"},{"target_artifact_id":"experiment-exp-wiki-experiments-als-regional-onset-spread","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: TARDBP mentioned 2x in wiki/mechanisms-exosome-mediated-propagation"},{"target_artifact_id":"experiment-exp-debate-d1ef3eb9ecab","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: TARDBP mentioned 2x in wiki/mechanisms-exosome-mediated-propagation"},{"target_artifact_id":"experiment-exp-wiki-experiments-lrrk2-gba-carrier-resilience-pd","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: LRRK2 mentioned 2x in wiki/mechanisms-exosome-mediated-propagation"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-4113b0e8","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-7693c291","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TARDBP'"},{"target_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Heat shock protein / proteostasis"},{"target_artifact_id":"hypothesis-h-dca3e907","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Serine/arginine protein kinase / RNA splicing"},{"target_artifact_id":"hypothesis-h-69d383ea","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Transglutaminase / protein cross-linking"},{"target_artifact_id":"hypothesis-h-84808267","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: LRP1 receptor-mediated transcytosis"},{"target_artifact_id":"hypothesis-h-7e0b5ade","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: LRP1 receptor-mediated transcytosis"},{"target_artifact_id":"hypothesis-h-b948c32c","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-637a53c9","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Heat shock protein / proteostasis"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-58e4635a","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: C1q / complement-mediated synapse elimination"},{"target_artifact_id":"hypothesis-h-4dd0d19b","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: LRP1 receptor-mediated transcytosis"},{"target_artifact_id":"hypothesis-h-0f00fd75","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"target_artifact_id":"hypothesis-h-73e29e3a","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"target_artifact_id":"hypothesis-h-e3e8407c","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: TFEB-mediated lysosomal biogenesis / PGC1α mitochondrial biogenesis coupling"},{"target_artifact_id":"hypothesis-h-2a4e4ad2","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: BNIP3/BNIP3L receptor-mediated mitophagy (PINK1/Parkin-independent)"},{"target_artifact_id":"hypothesis-h-d4f71a6b","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Transglutaminase-2 calcium-dependent protein cross-linking"},{"target_artifact_id":"hypothesis-h-54b9e0f5","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Heparan sulfate proteoglycan-mediated amyloid templating"},{"target_artifact_id":"hypothesis-h-c9486869","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: HSP70-HSP40 (DNAJB6) chaperone-mediated amyloid inhibition"},{"target_artifact_id":"hypothesis-h-5d943bfc","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: HSP70/HSP40 chaperone-mediated proteostasis"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: APOE-mediated cholesterol/lipid transport"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-15336069","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-69d383ea","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Transglutaminase / protein cross-linking"},{"source_artifact_id":"hypothesis-h-84808267","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: LRP1 receptor-mediated transcytosis"},{"source_artifact_id":"hypothesis-h-7e0b5ade","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: LRP1 receptor-mediated transcytosis"},{"source_artifact_id":"hypothesis-h-4dd0d19b","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: LRP1 receptor-mediated transcytosis"},{"source_artifact_id":"hypothesis-h-0f00fd75","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"source_artifact_id":"hypothesis-h-73e29e3a","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"source_artifact_id":"hypothesis-h-e3e8407c","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: TFEB-mediated lysosomal biogenesis / PGC1α mitochondrial biogenesis coupling"},{"source_artifact_id":"hypothesis-h-2a4e4ad2","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: BNIP3/BNIP3L receptor-mediated mitophagy (PINK1/Parkin-independent)"},{"source_artifact_id":"hypothesis-h-d4f71a6b","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Transglutaminase-2 calcium-dependent protein cross-linking"},{"source_artifact_id":"hypothesis-h-54b9e0f5","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Heparan sulfate proteoglycan-mediated amyloid templating"},{"source_artifact_id":"hypothesis-h-c9486869","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: HSP70-HSP40 (DNAJB6) chaperone-mediated amyloid inhibition"},{"source_artifact_id":"hypothesis-h-5d943bfc","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: HSP70/HSP40 chaperone-mediated proteostasis"},{"source_artifact_id":"hypothesis-h-c9c79e3e","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: APOE-mediated cholesterol/lipid transport"},{"source_artifact_id":"hypothesis-h-7e846ceb","link_type":"related","strength":0.5931000000000001,"evidence":"Reverse: Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-b948c32c","link_type":"related","strength":0.5913,"evidence":"Reverse: Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":0.6048,"evidence":"Reverse: Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-d0a564e8","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.5679000000000001,"evidence":"Reverse: Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.6075,"evidence":"Reverse: Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-072b2f5d","link_type":"related","strength":0.5940000000000001,"evidence":"Reverse: Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-4fabd9ce","link_type":"related","strength":0.6075,"evidence":"Reverse: Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-eea667a9","link_type":"related","strength":0.6003000000000001,"evidence":"Reverse: Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-74777459","link_type":"related","strength":0.5877,"evidence":"Reverse: Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'Exosome-Mediated Pathological Protein Propagation' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"hypothesis-h-d2df6eaf","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-d40d2659","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-dca3e907","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-637a53c9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-58e4635a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1acdd55e","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6ce4884a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-d7121bcc","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-881362dc","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-4113b0e8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-mechanisms-exosome-mediated-propagation","is_canonical":true,"supersede_chain":["wiki-mechanisms-exosome-mediated-propagation"]}