{"artifact":{"id":"wiki-mechanisms-hypoxia-response","artifact_type":"wiki_page","entity_ids":"[\"mechanisms-hypoxia-response\"]","title":"Hypoxia Response Pathway","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"7b7a017bbdb6533ec136383e8a67440598551a400508fbf63c67a1219f49e365","metadata":{"slug":"mechanisms-hypoxia-response","kg_node_id":null,"entity_type":"mechanism","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-7435a3c567ba","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"mechanisms-hypoxia-response"},"_schema_version":1},"created_at":"2026-04-02T07:19:50-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"ccae40bd-3ab4-444c-962b-fa86add1ca94","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-c98631a3-a95e-4621-a68f-9cf145b22b97","link_type":"mentions","strength":0.5,"evidence":"Content: NLRP3 mentioned 4x in wiki/mechanisms-hypoxia-response"},{"target_artifact_id":"experiment-exp-9d2d59a7-8bc0-4399-aab0-2538f3a07b6f","link_type":"mentions","strength":0.5,"evidence":"Content: NLRP3 mentioned 4x in wiki/mechanisms-hypoxia-response"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'Hypoxia Response Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-e7e1f943","link_type":"mentions","strength":0.696,"evidence":"Mechanism wiki 'Hypoxia Response Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-441b25ba","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'Hypoxia Response Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.7,"evidence":"Mechanism wiki 'Hypoxia Response Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-969bd8e0","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"hypothesis-h-7e0b5ade","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"hypothesis-h-1e564178","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Response'"},{"target_artifact_id":"hypothesis-h-ac55ff26","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"hypothesis-h-1e2bd420","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"hypothesis-h-ecacd219","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Response'"},{"target_artifact_id":"hypothesis-h-fd52a7a0","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'pathway'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"experiment-exp-wiki-experiments-nlrp3-inflammasome-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: NLRP3 mentioned 4x in wiki/mechanisms-hypoxia-response"},{"target_artifact_id":"hypothesis-h-e6437136","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-c8ccbee8","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-dca3e907","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-a1b56d74","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-5706bbd7","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-7a8d7379","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-ec731b7a","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-ae1b2beb","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-b0cda336","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-1a34778f","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-959a4677","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-ba3a948a","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-38292315","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-82922df8","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-3a901ec3","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-0dea0ed5","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-98b431ba","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-6ce4884a","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-50a535f9","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-881362dc","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-41bc2d38","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-6c83282d","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-74777459","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-bdbd2120","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'HYPOXIA'"},{"target_artifact_id":"hypothesis-h-856feb98","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.9,"evidence":"Wiki page mentions gene TH targeted by hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"wiki-genes-adora2b","link_type":"see_also","strength":0.6,"evidence":"KG edge: upregulates"},{"target_artifact_id":"wiki-genes-hif1a","link_type":"see_also","strength":0.6,"evidence":"KG edge: mediates"},{"target_artifact_id":"wiki-mechanisms-bbb-transport-mechanisms","link_type":"see_also","strength":0.6,"evidence":"KG edge: causes"},{"target_artifact_id":"wiki-genes-c3","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-genes-c3ar1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-genes-cav1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-entities-nf-kb","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-genes-ppargc1a","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"target_artifact_id":"wiki-institutions-packard-center-als","link_type":"see_also","strength":0.6,"evidence":"KG edge: contributes_to"},{"target_artifact_id":"wiki-entities-aria-imaging","link_type":"see_also","strength":0.6,"evidence":"KG edge: upregulates"},{"target_artifact_id":"wiki-experiments-autophagy-enhancement-drug-screening","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TREM2'"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TREM2'"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TREM2'"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'TREM2'"},{"target_artifact_id":"hypothesis-h-1e564178","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-ecacd219","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-0e675a41","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'HYPOXIA'"},{"target_artifact_id":"hypothesis-h-a4e259e0","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-16ee87a4","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-2a4e4ad2","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-27bc0569","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-51e7234f","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-5d943bfc","link_type":"mentions","strength":0.5,"evidence":"Entity 'HYPOXIA' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-aa8b4952","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Mitochondrial calcium uniporter pathway"},{"target_artifact_id":"hypothesis-h-ae1b2beb","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"target_artifact_id":"hypothesis-h-5e68b4ad","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"target_artifact_id":"hypothesis-h-82922df8","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Nrf2 / oxidative stress response"},{"target_artifact_id":"hypothesis-h-4113b0e8","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"target_artifact_id":"hypothesis-h-441b25ba","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Beta-secretase / amyloidogenic pathway"},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"target_artifact_id":"hypothesis-h-0f00fd75","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"target_artifact_id":"hypothesis-h-73e29e3a","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"target_artifact_id":"hypothesis-h-a4e259e0","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Vagal cholinergic anti-inflammatory pathway (α7nAChR)"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-aa8b4952","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Mitochondrial calcium uniporter pathway"},{"source_artifact_id":"hypothesis-h-5e68b4ad","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"source_artifact_id":"hypothesis-h-4113b0e8","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"source_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"source_artifact_id":"hypothesis-h-0f00fd75","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"source_artifact_id":"hypothesis-h-73e29e3a","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"source_artifact_id":"hypothesis-h-a4e259e0","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Vagal cholinergic anti-inflammatory pathway (α7nAChR)"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'Hypoxia Response Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-e7e1f943","link_type":"related","strength":0.6264,"evidence":"Reverse: Mechanism wiki 'Hypoxia Response Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-441b25ba","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'Hypoxia Response Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.63,"evidence":"Reverse: Mechanism wiki 'Hypoxia Response Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"hypothesis-h-ecacd219","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-969bd8e0","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-7e0b5ade","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1e564178","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ac55ff26","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1e2bd420","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-fd52a7a0","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-e6437136","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-c8ccbee8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-dca3e907","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-a1b56d74","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-5706bbd7","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-7a8d7379","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ec731b7a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ae1b2beb","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-b0cda336","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1a34778f","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-959a4677","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ba3a948a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-38292315","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-82922df8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-3a901ec3","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-0dea0ed5","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-98b431ba","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6ce4884a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-50a535f9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-881362dc","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-41bc2d38","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6c83282d","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-74777459","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-bdbd2120","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-856feb98","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-mechanisms-hypoxia-response","is_canonical":true,"supersede_chain":["wiki-mechanisms-hypoxia-response"]}