{"artifact":{"id":"wiki-mechanisms-ms4a4a-ms4a6a-trem2-negative-regulation-ad-causal-chain","artifact_type":"wiki_page","entity_ids":"[\"mechanisms-ms4a4a-ms4a6a-trem2-negative-regulation-ad-causal-chain\"]","title":"MS4A4A/MS4A6A → TREM2 Negative Regulation → Microglial Dysfunction → AD Causal Chain","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"cfb679a0a738119af3e8ff0b62cac1d5481fd617ccb7987ae9c375300ce7e331","metadata":{"slug":"mechanisms-ms4a4a-ms4a6a-trem2-negative-regulation-ad-causal-chain","kg_node_id":null,"entity_type":"mechanism","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-ef46fce77581","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"mechanisms-ms4a4a-ms4a6a-trem2-negative-regulation-ad-causal-chain"},"_schema_version":1},"created_at":"2026-04-02T07:19:55-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"4c01f236-6726-472e-b61d-7bf84a72e8a8","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"analysis-SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-04-gap-neuroinflammation-microglial-20260404","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-11-gap-debate-20260410-111113-052488a8","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-11-gap-debate-20260410-112636-141592ba","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'MS4A4A/MS4A6A → TREM2 Negative Regulation → Microglial Dysfunction → AD Causal Chain' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.7,"evidence":"Mechanism wiki 'MS4A4A/MS4A6A → TREM2 Negative Regulation → Microglial Dysfunction → AD Causal Chain' references gene/pathway from hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"hypothesis-h-5daecb6e","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Microglial'"},{"target_artifact_id":"hypothesis-h-470ff83e","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Microglial'"},{"target_artifact_id":"hypothesis-h-38292315","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Microglial'"},{"target_artifact_id":"hypothesis-h-782b40b1","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Microglial'"},{"target_artifact_id":"analysis-sda-2026-04-01-001","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'TREM2'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'dysfunction'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-microglial-subtypes-20260402004119","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'microglial'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'dysfunction'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 34x in wiki/mechanisms-ms4a4a-ms4a6a-trem2-negative-regulation-ad-causal-chain"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 34x in wiki/mechanisms-ms4a4a-ms4a6a-trem2-negative-regulation-ad-causal-chain"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"mentions","strength":0.5,"evidence":"Content: TREM2 mentioned 34x in wiki/mechanisms-ms4a4a-ms4a6a-trem2-negative-regulation-ad-causal-chain"},{"target_artifact_id":"experiment-exp-wiki-experiments-multi-ethnic-pd-gwas","link_type":"mentions","strength":0.5,"evidence":"Content: GWAS mentioned 3x in wiki/mechanisms-ms4a4a-ms4a6a-trem2-negative-regulation-ad-causal-chain"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.7,"evidence":"Gene match: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"related","strength":0.7,"evidence":"Wiki page for TREM2 related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-non-motor-symptom-progression-pd","link_type":"related","strength":0.7,"evidence":"Wiki page for REM related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for TREM2 related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for CT related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"related","strength":0.7,"evidence":"Wiki page for TREM2 related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.6,"evidence":"Entity name match: TREM2"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"mentions","strength":0.6,"evidence":"Entity name match: TREM2"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"mentions","strength":0.6,"evidence":"Entity name match: TREM2"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"related","strength":0.7,"evidence":"Wiki title matches hypothesis target gene: trem2"},{"target_artifact_id":"hypothesis-h-d2df6eaf","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Reelin signaling / cytoskeletal regulation"},{"target_artifact_id":"hypothesis-h-5daecb6e","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Purinergic signaling / microglial homeostasis"},{"target_artifact_id":"hypothesis-h-19003961","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Arginine methylation / epigenetic regulation"},{"target_artifact_id":"hypothesis-h-d2722680","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Epigenetic regulation"},{"target_artifact_id":"hypothesis-h-3f02f222","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"target_artifact_id":"hypothesis-h-470ff83e","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"target_artifact_id":"hypothesis-h-f99ce4ca","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Purinergic signaling / microglial homeostasis"},{"target_artifact_id":"hypothesis-h-38292315","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"target_artifact_id":"hypothesis-h-43f72e21","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: AMPK / energy sensing / metabolic regulation"},{"target_artifact_id":"hypothesis-h-d7121bcc","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Epigenetic regulation"},{"target_artifact_id":"hypothesis-h-881362dc","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Epigenetic regulation"},{"target_artifact_id":"hypothesis-h-782e55f6","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Epigenetic regulation"},{"target_artifact_id":"hypothesis-h-8597755b","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: TREM2-DAP12 microglial signaling"},{"target_artifact_id":"hypothesis-h-addc0a61","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Epigenetic regulation"},{"target_artifact_id":"hypothesis-h-a90e2e89","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Epigenetic regulation"},{"target_artifact_id":"hypothesis-h-baba5269","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Epigenetic regulation"},{"target_artifact_id":"hypothesis-h-29ef94d5","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: CREB/BDNF epigenetic regulation of synaptic plasticity"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: TREM2/TYROBP microglial activation → senescence transition"},{"target_artifact_id":"hypothesis-h-3d545f4e","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: TREM2 → SYK → PI3K/mTOR phagocytic signaling"},{"target_artifact_id":"hypothesis-h-51e7234f","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: mTORC1/TFEB autophagy regulation"},{"target_artifact_id":"analysis-SDA-2026-04-04-gap-neuro-microglia-early-ad-20260404","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"wiki-biomarkers-strem2-soluble-trem2","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-biomarkers-strem2","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-al002-trem2-agonist-alzheimers","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-entities-trem2","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-trem2-als","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-trem2-gene-mechanism-therapy-chain","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-trem2-ftd","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-astrocyte-subtypes","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-61196ade","link_type":"related","strength":0.54,"evidence":"Reverse: Entity name match: TREM2"},{"source_artifact_id":"hypothesis-h-3460f820","link_type":"related","strength":0.54,"evidence":"Reverse: Entity name match: TREM2"},{"source_artifact_id":"hypothesis-h-180807e5","link_type":"related","strength":0.54,"evidence":"Reverse: Entity name match: TREM2"},{"source_artifact_id":"hypothesis-h-d2df6eaf","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Reelin signaling / cytoskeletal regulation"},{"source_artifact_id":"hypothesis-h-19003961","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Arginine methylation / epigenetic regulation"},{"source_artifact_id":"hypothesis-h-d2722680","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Epigenetic regulation"},{"source_artifact_id":"hypothesis-h-3f02f222","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"source_artifact_id":"hypothesis-h-f99ce4ca","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Purinergic signaling / microglial homeostasis"},{"source_artifact_id":"hypothesis-h-43f72e21","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: AMPK / energy sensing / metabolic regulation"},{"source_artifact_id":"hypothesis-h-d7121bcc","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Epigenetic regulation"},{"source_artifact_id":"hypothesis-h-881362dc","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Epigenetic regulation"},{"source_artifact_id":"hypothesis-h-782e55f6","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Epigenetic regulation"},{"source_artifact_id":"hypothesis-h-8597755b","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"source_artifact_id":"hypothesis-h-addc0a61","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Epigenetic regulation"},{"source_artifact_id":"hypothesis-h-a90e2e89","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Epigenetic regulation"},{"source_artifact_id":"hypothesis-h-baba5269","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Epigenetic regulation"},{"source_artifact_id":"hypothesis-h-29ef94d5","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: CREB/BDNF epigenetic regulation of synaptic plasticity"},{"source_artifact_id":"hypothesis-h-3d545f4e","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"hypothesis-h-51e7234f","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: mTORC1/TFEB autophagy regulation"},{"source_artifact_id":"analysis-SDA-2026-04-04-gap-neuro-microglia-early-ad-20260404","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-04-gap-neuroinflammation-microglial-20260404","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-11-gap-debate-20260410-111113-052488a8","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-11-gap-debate-20260410-112636-141592ba","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.8,"evidence":"Hypothesis involves entity 'TREM2' with wiki page"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.8,"evidence":"Hypothesis involves entity 'TREM2' with wiki page"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'MS4A4A/MS4A6A → TREM2 Negative Regulation → Microglial Dysfunction → AD Causal Chain' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.63,"evidence":"Reverse: Mechanism wiki 'MS4A4A/MS4A6A → TREM2 Negative Regulation → Microglial Dysfunction → AD Causal Chain' references gene/pathway from hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"hypothesis-h-seaad-51323624","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TREM2 described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"related","strength":0.7,"evidence":"Experiment targets TREM2 described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-non-motor-symptom-progression-pd","link_type":"related","strength":0.7,"evidence":"Experiment targets REM described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets TREM2 described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets CT described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"related","strength":0.7,"evidence":"Experiment targets TREM2 described in wiki"},{"source_artifact_id":"hypothesis-h-5daecb6e","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-470ff83e","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-38292315","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-782b40b1","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-microglial-subtypes-20260402004119","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-001","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"wiki-biomarkers-strem2-soluble-trem2","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-biomarkers-strem2","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-al002-trem2-agonist-alzheimers","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-entities-trem2","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-trem2-als","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-trem2-gene-mechanism-therapy-chain","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-trem2-ftd","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-astrocyte-subtypes","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-mechanisms-ms4a4a-ms4a6a-trem2-negative-regulation-ad-causal-chain","is_canonical":true,"supersede_chain":["wiki-mechanisms-ms4a4a-ms4a6a-trem2-negative-regulation-ad-causal-chain"]}