{"artifact":{"id":"wiki-mechanisms-neurotransmitter-changes-4r-tauopathies","artifact_type":"wiki_page","entity_ids":"[\"mechanisms-neurotransmitter-changes-4r-tauopathies\"]","title":"Neurotransmitter System Changes in 4R-Tauopathies: Cross-Disease Comparison","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"fccb508ae1215bf6babcd5f4f993097e4251be0a89582a3b1bfe2da71e3c94dc","metadata":{"slug":"mechanisms-neurotransmitter-changes-4r-tauopathies","kg_node_id":null,"entity_type":"mechanism","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-f42d15623ad8","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"mechanisms-neurotransmitter-changes-4r-tauopathies"},"_schema_version":1},"created_at":"2026-04-02T07:19:52-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"394b0b14-0aeb-405f-8997-80dbe5abfcfc","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-32576dcf-a6c7-4ff9-b7b8-37903a89693e","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: MAPT mentioned 2x in wiki/mechanisms-neurotransmitter-changes-4r-tauopathies"},{"target_artifact_id":"experiment-exp-65257309-482b-4700-8d80-284109e46653","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: MAPT mentioned 2x in wiki/mechanisms-neurotransmitter-changes-4r-tauopathies"},{"target_artifact_id":"experiment-exp-62a12833-386d-46c4-b201-612a3e517512","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: SERT mentioned 2x in wiki/mechanisms-neurotransmitter-changes-4r-tauopathies"},{"target_artifact_id":"hypothesis-h-e0183502","link_type":"mentions","strength":0.63,"evidence":"Mechanism wiki 'Neurotransmitter System Changes in 4R-Tauopathies: Cross-Disease Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-ee1df336","link_type":"mentions","strength":0.686,"evidence":"Mechanism wiki 'Neurotransmitter System Changes in 4R-Tauopathies: Cross-Disease Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-856feb98","link_type":"mentions","strength":0.69,"evidence":"Mechanism wiki 'Neurotransmitter System Changes in 4R-Tauopathies: Cross-Disease Comparison' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-69d383ea","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Cross'"},{"target_artifact_id":"hypothesis-h-62e56eb9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'System'"},{"target_artifact_id":"hypothesis-h-959a4677","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'System'"},{"target_artifact_id":"hypothesis-h-eea667a9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Cross'"},{"target_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'System'"},{"target_artifact_id":"analysis-sda-2026-04-01-001","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'disease'"},{"target_artifact_id":"analysis-sda-2026-04-01-002","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'Disease'"},{"target_artifact_id":"analysis-sda-2026-04-01-003","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'disease'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'disease'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'disease'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'disease'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'changes'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'changes'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'Disease'"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'changes'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'disease'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'Disease'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"experiment-exp-wiki-experiments-pre-symptomatic-tau-detection-mapt","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: MAPT mentioned 2x in wiki/mechanisms-neurotransmitter-changes-4r-tauopathies"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.9,"evidence":"Wiki page mentions gene TH targeted by hypothesis"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-69d383ea","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Transglutaminase / protein cross-linking"},{"target_artifact_id":"hypothesis-h-8b7727c1","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Bacterial curli amyloid → α-synuclein cross-seeding (gut-brain axis)"},{"target_artifact_id":"hypothesis-h-d4f71a6b","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Transglutaminase-2 calcium-dependent protein cross-linking"},{"target_artifact_id":"hypothesis-h-7693c291","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: TDP-43 RNA-binding / liquid-liquid phase separation cross-seeding"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'disease'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'disease'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'changes'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'changes'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'changes'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'changes'"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-8b7727c1","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Bacterial curli amyloid → α-synuclein cross-seeding (gut-brain axis)"},{"source_artifact_id":"hypothesis-h-d4f71a6b","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Transglutaminase-2 calcium-dependent protein cross-linking"},{"source_artifact_id":"hypothesis-h-7693c291","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: TDP-43 RNA-binding / liquid-liquid phase separation cross-seeding"},{"source_artifact_id":"hypothesis-h-e0183502","link_type":"related","strength":0.5670000000000001,"evidence":"Reverse: Mechanism wiki 'Neurotransmitter System Changes in 4R-Tauopathies: Cross-Disease Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-ee1df336","link_type":"related","strength":0.6174000000000001,"evidence":"Reverse: Mechanism wiki 'Neurotransmitter System Changes in 4R-Tauopathies: Cross-Disease Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-856feb98","link_type":"related","strength":0.621,"evidence":"Reverse: Mechanism wiki 'Neurotransmitter System Changes in 4R-Tauopathies: Cross-Disease Comparison' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"hypothesis-h-69d383ea","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-62e56eb9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-959a4677","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-eea667a9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.6,"evidence":"Analysis discusses entity covered by wiki page"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.6,"evidence":"Analysis discusses entity covered by wiki page"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-001","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-002","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-003","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.6,"evidence":"Analysis discusses entity covered by wiki page"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.6,"evidence":"Analysis discusses entity covered by wiki page"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.6,"evidence":"Analysis discusses entity covered by wiki page"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.6,"evidence":"Analysis discusses entity covered by wiki page"}],"current_artifact_id":"wiki-mechanisms-neurotransmitter-changes-4r-tauopathies","is_canonical":true,"supersede_chain":["wiki-mechanisms-neurotransmitter-changes-4r-tauopathies"]}