{"artifact":{"id":"wiki-mechanisms-protein-synthesis","artifact_type":"wiki_page","entity_ids":"[\"mechanisms-protein-synthesis\"]","title":"Protein Synthesis Pathway","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"2f63ff63d1cfadb5f8c0b13353db550d5f38bf854dbaf34d3607edd94318949c","metadata":{"slug":"mechanisms-protein-synthesis","kg_node_id":null,"entity_type":"mechanism","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-543ec1b5d787","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"mechanisms-protein-synthesis"},"_schema_version":1},"created_at":"2026-04-02T07:20:02-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"fbe622bd-2566-4e00-8db1-135e127c9f38","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-03a934e0-f1ad-47aa-9dcd-9cf748477080","link_type":"mentions","strength":0.6,"evidence":"Title match: Protein Synthesis Pathway"},{"target_artifact_id":"hypothesis-h-7e846ceb","link_type":"mentions","strength":0.659,"evidence":"Mechanism wiki 'Protein Synthesis Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-e0183502","link_type":"mentions","strength":0.63,"evidence":"Mechanism wiki 'Protein Synthesis Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-4fabd9ce","link_type":"mentions","strength":0.675,"evidence":"Mechanism wiki 'Protein Synthesis Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-eea667a9","link_type":"mentions","strength":0.667,"evidence":"Mechanism wiki 'Protein Synthesis Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-ee1df336","link_type":"mentions","strength":0.686,"evidence":"Mechanism wiki 'Protein Synthesis Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-856feb98","link_type":"mentions","strength":0.69,"evidence":"Mechanism wiki 'Protein Synthesis Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Protein'"},{"target_artifact_id":"hypothesis-h-dca3e907","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Protein'"},{"target_artifact_id":"hypothesis-h-969bd8e0","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"hypothesis-h-7e0b5ade","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"hypothesis-h-ac55ff26","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"hypothesis-h-13bbfdc5","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Synthesis'"},{"target_artifact_id":"hypothesis-h-1e2bd420","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"hypothesis-h-fd52a7a0","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Synthesis'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'protein'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'pathway'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"experiment-exp-wiki-experiments-lrrk2-gba-carrier-resilience-pd","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: LRRK2 mentioned 2x in wiki/mechanisms-protein-synthesis"},{"target_artifact_id":"hypothesis-h-ec731b7a","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-ae1b2beb","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-5e68b4ad","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-b3d6ecc2","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-0e0cc0c1","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-1acdd55e","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-f71a9791","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-97aa8486","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-8196b893","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-ecacd219","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-98b431ba","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-e7e1f943","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-fdb07848","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'PROTEIN SYNTHESIS'"},{"target_artifact_id":"hypothesis-h-62f9fc90","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'PROTEIN SYNTHESIS'"},{"target_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'PROTEIN SYNTHESIS'"},{"target_artifact_id":"hypothesis-h-baba5269","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"wiki-genes-mtor","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"target_artifact_id":"wiki-events-mds-2026-parkinsons-diagnostics-biomarkers","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"target_artifact_id":"wiki-proteins-igf2r","link_type":"see_also","strength":0.6,"evidence":"KG edge: regulates"},{"target_artifact_id":"wiki-genes-myc","link_type":"see_also","strength":0.6,"evidence":"KG edge: promotes"},{"target_artifact_id":"wiki-diseases-neurodegeneration","link_type":"see_also","strength":0.6,"evidence":"KG edge: contributes_to"},{"target_artifact_id":"hypothesis-h-13bbfdc5","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-seaad-v4-26ba859b","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v4-20260402065846","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'PROTEIN SYNTHESIS'"},{"target_artifact_id":"hypothesis-h-e5a1c16b","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-16ee87a4","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-7693c291","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-51e7234f","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-5d943bfc","link_type":"mentions","strength":0.5,"evidence":"Entity 'PROTEIN SYNTHESIS' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-aa8b4952","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Mitochondrial calcium uniporter pathway"},{"target_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Heat shock protein / proteostasis"},{"target_artifact_id":"hypothesis-h-dca3e907","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Serine/arginine protein kinase / RNA splicing"},{"target_artifact_id":"hypothesis-h-69d383ea","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Transglutaminase / protein cross-linking"},{"target_artifact_id":"hypothesis-h-b948c32c","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-637a53c9","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Heat shock protein / proteostasis"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"target_artifact_id":"hypothesis-h-ae1b2beb","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"target_artifact_id":"hypothesis-h-5e68b4ad","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"target_artifact_id":"hypothesis-h-4113b0e8","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"target_artifact_id":"hypothesis-h-441b25ba","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Beta-secretase / amyloidogenic pathway"},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"target_artifact_id":"hypothesis-h-0f00fd75","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"target_artifact_id":"hypothesis-h-73e29e3a","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"target_artifact_id":"hypothesis-h-a87702b6","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Brain cholesterol homeostasis (HMGCR synthesis → CYP46A1 elimination)"},{"target_artifact_id":"hypothesis-h-a4e259e0","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Vagal cholinergic anti-inflammatory pathway (α7nAChR)"},{"target_artifact_id":"hypothesis-h-d4f71a6b","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Transglutaminase-2 calcium-dependent protein cross-linking"},{"target_artifact_id":"hypothesis-h-58e655ee","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Sphingolipid biosynthesis / cholesterol-sphingomyelin lipid raft assembly"},{"target_artifact_id":"hypothesis-h-8fe389e8","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene HDAC"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-aa8b4952","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Mitochondrial calcium uniporter pathway"},{"source_artifact_id":"hypothesis-h-69d383ea","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Transglutaminase / protein cross-linking"},{"source_artifact_id":"hypothesis-h-b948c32c","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"source_artifact_id":"hypothesis-h-637a53c9","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Heat shock protein / proteostasis"},{"source_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"source_artifact_id":"hypothesis-h-d0a564e8","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"source_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"source_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"source_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Apolipoprotein E lipid transport"},{"source_artifact_id":"hypothesis-h-4113b0e8","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"source_artifact_id":"hypothesis-h-441b25ba","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Beta-secretase / amyloidogenic pathway"},{"source_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"source_artifact_id":"hypothesis-h-0f00fd75","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"source_artifact_id":"hypothesis-h-73e29e3a","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"source_artifact_id":"hypothesis-h-a87702b6","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Brain cholesterol homeostasis (HMGCR synthesis → CYP46A1 elimination)"},{"source_artifact_id":"hypothesis-h-a4e259e0","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Vagal cholinergic anti-inflammatory pathway (α7nAChR)"},{"source_artifact_id":"hypothesis-h-d4f71a6b","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Transglutaminase-2 calcium-dependent protein cross-linking"},{"source_artifact_id":"hypothesis-h-58e655ee","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Sphingolipid biosynthesis / cholesterol-sphingomyelin lipid raft assembly"},{"source_artifact_id":"experiment-exp-03a934e0-f1ad-47aa-9dcd-9cf748477080","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Protein Synthesis Pathway"},{"source_artifact_id":"hypothesis-h-7e846ceb","link_type":"related","strength":0.5931000000000001,"evidence":"Reverse: Mechanism wiki 'Protein Synthesis Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-e0183502","link_type":"related","strength":0.5670000000000001,"evidence":"Reverse: Mechanism wiki 'Protein Synthesis Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-4fabd9ce","link_type":"related","strength":0.6075,"evidence":"Reverse: Mechanism wiki 'Protein Synthesis Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-eea667a9","link_type":"related","strength":0.6003000000000001,"evidence":"Reverse: Mechanism wiki 'Protein Synthesis Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-ee1df336","link_type":"related","strength":0.6174000000000001,"evidence":"Reverse: Mechanism wiki 'Protein Synthesis Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-856feb98","link_type":"related","strength":0.621,"evidence":"Reverse: Mechanism wiki 'Protein Synthesis Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-dca3e907","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-969bd8e0","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-7e0b5ade","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ac55ff26","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-13bbfdc5","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1e2bd420","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-fd52a7a0","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ec731b7a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ae1b2beb","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-5e68b4ad","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-b3d6ecc2","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-0e0cc0c1","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1acdd55e","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-f71a9791","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-97aa8486","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-8196b893","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ecacd219","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-98b431ba","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-e7e1f943","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-fdb07848","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-62f9fc90","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-4bb7fd8c","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-baba5269","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v4-20260402065846","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-mechanisms-protein-synthesis","is_canonical":true,"supersede_chain":["wiki-mechanisms-protein-synthesis"]}