{"artifact":{"id":"wiki-mechanisms-psen1-presenilin-1-ad-causal-chain","artifact_type":"wiki_page","entity_ids":"[\"mechanisms-psen1-presenilin-1-ad-causal-chain\"]","title":"PSEN1 Presenilin 1 AD Causal Chain","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"bac6c5c1905ccd72a999bd73261d06d19135462b8d69cf330259dd1929f38eba","metadata":{"slug":"mechanisms-psen1-presenilin-1-ad-causal-chain","kg_node_id":null,"entity_type":"mechanism","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-6f8c48935b79","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"mechanisms-psen1-presenilin-1-ad-causal-chain"},"_schema_version":1},"created_at":"2026-04-02T07:19:56-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"eb33019c-9dbe-45e4-bb48-19b8a965979f","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-8611f56b-0e18-40e2-a0d4-0be2bff633ec","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSEN1"},{"target_artifact_id":"experiment-exp-4c97be59-973e-4997-bca9-8c28a6affaa8","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSEN1"},{"target_artifact_id":"experiment-exp-dfc5aacc-bf00-44d1-897f-5cf474b3c7a7","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSEN1"},{"target_artifact_id":"experiment-exp-94b13181-2a62-4f75-ae37-d0983058aa76","link_type":"mentions","strength":0.8,"evidence":"Gene target: PSEN1"},{"target_artifact_id":"experiment-exp-660b0861-aba0-4355-aa4f-e811f4a549c4","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSEN1"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'PSEN1 Presenilin 1 AD Causal Chain' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-441b25ba","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'PSEN1 Presenilin 1 AD Causal Chain' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.7,"evidence":"Mechanism wiki 'PSEN1 Presenilin 1 AD Causal Chain' references gene/pathway from hypothesis"},{"target_artifact_id":"experiment-exp-wiki-experiments-metal-ion-homeostasis-alzheimers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSEN1"},{"target_artifact_id":"experiment-exp-wiki-experiments-neural-stem-cell-therapy-alzheimers-disease","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PSEN1"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-3d545f4e","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-15336069","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene APOE"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-seaad-56fa6428","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene GFAP"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-3d545f4e","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"experiment-exp-8611f56b-0e18-40e2-a0d4-0be2bff633ec","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSEN1"},{"source_artifact_id":"experiment-exp-4c97be59-973e-4997-bca9-8c28a6affaa8","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSEN1"},{"source_artifact_id":"experiment-exp-dfc5aacc-bf00-44d1-897f-5cf474b3c7a7","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSEN1"},{"source_artifact_id":"experiment-exp-94b13181-2a62-4f75-ae37-d0983058aa76","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: PSEN1"},{"source_artifact_id":"experiment-exp-660b0861-aba0-4355-aa4f-e811f4a549c4","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSEN1"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'PSEN1 Presenilin 1 AD Causal Chain' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-441b25ba","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'PSEN1 Presenilin 1 AD Causal Chain' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.63,"evidence":"Reverse: Mechanism wiki 'PSEN1 Presenilin 1 AD Causal Chain' references gene/pathway from hypothesis"},{"source_artifact_id":"experiment-exp-wiki-experiments-metal-ion-homeostasis-alzheimers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSEN1"},{"source_artifact_id":"experiment-exp-wiki-experiments-neural-stem-cell-therapy-alzheimers-disease","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PSEN1"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-mechanisms-psen1-presenilin-1-ad-causal-chain","is_canonical":true,"supersede_chain":["wiki-mechanisms-psen1-presenilin-1-ad-causal-chain"]}