{"artifact":{"id":"wiki-mechanisms-tnap-p2x7-ctcf-axis-tauopathy","artifact_type":"wiki_page","entity_ids":"[\"mechanisms-tnap-p2x7-ctcf-axis-tauopathy\"]","title":"TNAP/P2X7R/CTCF Signaling Axis in Tauopathies","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"10df4c728908575f85abc81defd970712236e71005436067c1385226657365ce","metadata":{"slug":"mechanisms-tnap-p2x7-ctcf-axis-tauopathy","kg_node_id":null,"entity_type":"mechanism","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-ad494873f246","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"mechanisms-tnap-p2x7-ctcf-axis-tauopathy"},"_schema_version":1},"created_at":"2026-04-02T07:19:54-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"6ad5eea9-057a-4104-b20c-cec2711acd7f","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-eaf169e6-564f-4431-8060-d8f56667a994","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: CDK5 mentioned 2x in wiki/mechanisms-tnap-p2x7-ctcf-axis-tauopathy"},{"target_artifact_id":"experiment-exp-32576dcf-a6c7-4ff9-b7b8-37903a89693e","link_type":"mentions","strength":0.5,"evidence":"Content: MAPT mentioned 3x in wiki/mechanisms-tnap-p2x7-ctcf-axis-tauopathy"},{"target_artifact_id":"experiment-exp-65257309-482b-4700-8d80-284109e46653","link_type":"mentions","strength":0.5,"evidence":"Content: MAPT mentioned 3x in wiki/mechanisms-tnap-p2x7-ctcf-axis-tauopathy"},{"target_artifact_id":"hypothesis-h-e7e1f943","link_type":"mentions","strength":0.696,"evidence":"Mechanism wiki 'TNAP/P2X7R/CTCF Signaling Axis in Tauopathies' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-e6437136","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Axis'"},{"target_artifact_id":"hypothesis-h-0758b337","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Signaling'"},{"target_artifact_id":"hypothesis-h-ba3a948a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Axis'"},{"target_artifact_id":"hypothesis-h-50a535f9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Axis'"},{"target_artifact_id":"hypothesis-h-6c83282d","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Axis'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"experiment-exp-wiki-experiments-pre-symptomatic-tau-detection-mapt","link_type":"mentions","strength":0.5,"evidence":"Content: MAPT mentioned 3x in wiki/mechanisms-tnap-p2x7-ctcf-axis-tauopathy"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.9,"evidence":"Wiki page mentions gene TH targeted by hypothesis"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for CT related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-e6437136","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-ba3a948a","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-50a535f9","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-6c83282d","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-d2df6eaf","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Reelin signaling / cytoskeletal regulation"},{"target_artifact_id":"hypothesis-h-5daecb6e","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Purinergic signaling / microglial homeostasis"},{"target_artifact_id":"hypothesis-h-c35493aa","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Glycocalyx / extracellular matrix signaling"},{"target_artifact_id":"hypothesis-h-05b8894a","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Netrin-1 axon guidance signaling"},{"target_artifact_id":"hypothesis-h-0758b337","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Purinergic signaling"},{"target_artifact_id":"hypothesis-h-db6aa4b1","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Astrocyte reactivity signaling"},{"target_artifact_id":"hypothesis-h-a1b56d74","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Insulin/IGF metabolic signaling"},{"target_artifact_id":"hypothesis-h-7d4a24d3","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Astrocyte reactivity signaling"},{"target_artifact_id":"hypothesis-h-3d993b5d","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Insulin/IGF metabolic signaling"},{"target_artifact_id":"hypothesis-h-072b2f5d","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Dopamine D2 receptor signaling"},{"target_artifact_id":"hypothesis-h-35f04e1b","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Vascular / VEGF signaling"},{"target_artifact_id":"hypothesis-h-6a065252","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: TGF-β anti-inflammatory signaling"},{"target_artifact_id":"hypothesis-h-cb833ed8","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Cellular senescence / SASP signaling"},{"target_artifact_id":"hypothesis-h-7957bb2a","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Cellular senescence / SASP signaling"},{"target_artifact_id":"hypothesis-h-bb518928","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Cellular senescence / SASP signaling"},{"target_artifact_id":"hypothesis-h-3f02f222","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"target_artifact_id":"hypothesis-h-470ff83e","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"target_artifact_id":"hypothesis-h-f71a9791","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: GPR37 / neuroprotectin signaling"},{"target_artifact_id":"hypothesis-h-ac55ff26","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Astrocyte reactivity signaling"},{"target_artifact_id":"hypothesis-h-f99ce4ca","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Purinergic signaling / microglial homeostasis"},{"target_artifact_id":"hypothesis-h-38292315","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: TREM2-DAP12 microglial signaling"},{"target_artifact_id":"hypothesis-h-fb56c8a0","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Vascular / VEGF signaling"},{"target_artifact_id":"hypothesis-h-3a901ec3","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Astrocyte reactivity signaling"},{"target_artifact_id":"hypothesis-h-41bc2d38","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Astrocyte reactivity signaling"},{"target_artifact_id":"hypothesis-h-8597755b","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"target_artifact_id":"hypothesis-h-6b84d8e2","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Hypocretin/orexin wakefulness signaling"},{"target_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Toll-like receptor 4 / innate immune signaling"},{"target_artifact_id":"hypothesis-h-f9c6fa3f","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: TGF-β anti-inflammatory signaling"},{"target_artifact_id":"hypothesis-h-de0d4364","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Acid sphingomyelinase / ceramide signaling"},{"target_artifact_id":"hypothesis-h-12599989","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Sphingolipid / ceramide signaling"},{"target_artifact_id":"hypothesis-h-fdb07848","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Sphingolipid / ceramide signaling"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: TREM2-DAP12 microglial signaling"},{"target_artifact_id":"hypothesis-h-8fe389e8","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Astrocyte reactivity signaling"},{"target_artifact_id":"hypothesis-h-3d545f4e","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"target_artifact_id":"hypothesis-h-f3fb3b91","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: TLR4/MyD88/NF-κB innate immune signaling"},{"target_artifact_id":"hypothesis-h-8b7727c1","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Bacterial curli amyloid → α-synuclein cross-seeding (gut-brain axis)"},{"target_artifact_id":"hypothesis-h-8f285020","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: AGE-RAGE → NF-κB inflammatory signaling in enteric glia"},{"target_artifact_id":"hypothesis-h-9adb5c9e","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Pannexin-1 hemichannel ATP release / purinergic signaling"},{"target_artifact_id":"hypothesis-h-826df660","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Optogenetic calcium signaling → mitochondrial fission/transfer"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: TREM2 → SYK → PI3K/mTOR phagocytic signaling"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: APOE-TREM2 lipid sensing / microglial phagocytosis axis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-d2df6eaf","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Reelin signaling / cytoskeletal regulation"},{"source_artifact_id":"hypothesis-h-5daecb6e","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Purinergic signaling / microglial homeostasis"},{"source_artifact_id":"hypothesis-h-c35493aa","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Glycocalyx / extracellular matrix signaling"},{"source_artifact_id":"hypothesis-h-05b8894a","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Netrin-1 axon guidance signaling"},{"source_artifact_id":"hypothesis-h-db6aa4b1","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Astrocyte reactivity signaling"},{"source_artifact_id":"hypothesis-h-a1b56d74","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Insulin/IGF metabolic signaling"},{"source_artifact_id":"hypothesis-h-7d4a24d3","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Astrocyte reactivity signaling"},{"source_artifact_id":"hypothesis-h-3d993b5d","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Insulin/IGF metabolic signaling"},{"source_artifact_id":"hypothesis-h-072b2f5d","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Dopamine D2 receptor signaling"},{"source_artifact_id":"hypothesis-h-35f04e1b","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Vascular / VEGF signaling"},{"source_artifact_id":"hypothesis-h-6a065252","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: TGF-β anti-inflammatory signaling"},{"source_artifact_id":"hypothesis-h-cb833ed8","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Cellular senescence / SASP signaling"},{"source_artifact_id":"hypothesis-h-7957bb2a","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Cellular senescence / SASP signaling"},{"source_artifact_id":"hypothesis-h-bb518928","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Cellular senescence / SASP signaling"},{"source_artifact_id":"hypothesis-h-3f02f222","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"source_artifact_id":"hypothesis-h-470ff83e","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"source_artifact_id":"hypothesis-h-f71a9791","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: GPR37 / neuroprotectin signaling"},{"source_artifact_id":"hypothesis-h-ac55ff26","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Astrocyte reactivity signaling"},{"source_artifact_id":"hypothesis-h-f99ce4ca","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Purinergic signaling / microglial homeostasis"},{"source_artifact_id":"hypothesis-h-38292315","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: TREM2-DAP12 microglial signaling"},{"source_artifact_id":"hypothesis-h-fb56c8a0","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Vascular / VEGF signaling"},{"source_artifact_id":"hypothesis-h-3a901ec3","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Astrocyte reactivity signaling"},{"source_artifact_id":"hypothesis-h-41bc2d38","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Astrocyte reactivity signaling"},{"source_artifact_id":"hypothesis-h-8597755b","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"source_artifact_id":"hypothesis-h-6b84d8e2","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Hypocretin/orexin wakefulness signaling"},{"source_artifact_id":"hypothesis-h-2e7eb2ea","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Toll-like receptor 4 / innate immune signaling"},{"source_artifact_id":"hypothesis-h-f9c6fa3f","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: TGF-β anti-inflammatory signaling"},{"source_artifact_id":"hypothesis-h-de0d4364","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Acid sphingomyelinase / ceramide signaling"},{"source_artifact_id":"hypothesis-h-12599989","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Sphingolipid / ceramide signaling"},{"source_artifact_id":"hypothesis-h-fdb07848","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Sphingolipid / ceramide signaling"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: TREM2-DAP12 microglial signaling"},{"source_artifact_id":"hypothesis-h-8fe389e8","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Astrocyte reactivity signaling"},{"source_artifact_id":"hypothesis-h-3d545f4e","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Short-chain fatty acid → GPR109A → NF-κB anti-inflammatory signaling"},{"source_artifact_id":"hypothesis-h-f3fb3b91","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: TLR4/MyD88/NF-κB innate immune signaling"},{"source_artifact_id":"hypothesis-h-8b7727c1","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Bacterial curli amyloid → α-synuclein cross-seeding (gut-brain axis)"},{"source_artifact_id":"hypothesis-h-8f285020","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: AGE-RAGE → NF-κB inflammatory signaling in enteric glia"},{"source_artifact_id":"hypothesis-h-9adb5c9e","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Pannexin-1 hemichannel ATP release / purinergic signaling"},{"source_artifact_id":"hypothesis-h-826df660","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Optogenetic calcium signaling → mitochondrial fission/transfer"},{"source_artifact_id":"hypothesis-h-3460f820","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: TREM2 → SYK → PI3K/mTOR phagocytic signaling"},{"source_artifact_id":"hypothesis-h-180807e5","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: APOE-TREM2 lipid sensing / microglial phagocytosis axis"},{"source_artifact_id":"hypothesis-h-e7e1f943","link_type":"related","strength":0.6264,"evidence":"Reverse: Mechanism wiki 'TNAP/P2X7R/CTCF Signaling Axis in Tauopathies' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets CT described in wiki"},{"source_artifact_id":"hypothesis-h-e6437136","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-0758b337","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ba3a948a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-50a535f9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6c83282d","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"open_question-24faebda-d367-4733-b6ff-401aad7052f6","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-5e8ce64f-e32a-4cb9-88ea-68e32dc9d787","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-e1e7f0ca-764f-4e81-9080-d257809b6d6a","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-5c19847f-df63-4378-a9aa-e338b8ce2f53","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-a23620c9-6a61-4ae3-b68e-d220337489c3","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"}],"current_artifact_id":"wiki-mechanisms-tnap-p2x7-ctcf-axis-tauopathy","is_canonical":true,"supersede_chain":["wiki-mechanisms-tnap-p2x7-ctcf-axis-tauopathy"]}