{"artifact":{"id":"wiki-mechanisms-trem2-amyloid-clearance-pathway","artifact_type":"wiki_page","entity_ids":"[\"mechanisms-trem2-amyloid-clearance-pathway\"]","title":"TREM2-Mediated Amyloid Clearance Pathway","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"f4cb926af5573d80f6efbf5eddec555f1298959db4b222fe146e63cfa85574ad","metadata":{"slug":"mechanisms-trem2-amyloid-clearance-pathway","kg_node_id":null,"entity_type":"pathway","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-9f8ea809df1d","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"mechanisms-trem2-amyloid-clearance-pathway"},"_schema_version":1},"created_at":"2026-04-02T07:19:54-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"196ff0a2-2b97-49c8-98b1-a7252e890ad4","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"analysis-SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-04-gap-neuroinflammation-microglial-20260404","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-11-gap-debate-20260410-111113-052488a8","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-11-gap-debate-20260410-112636-141592ba","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"hypothesis-h-b948c32c","link_type":"mentions","strength":0.657,"evidence":"Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.672,"evidence":"Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.644,"evidence":"Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.631,"evidence":"Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.675,"evidence":"Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.658,"evidence":"Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.7,"evidence":"Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"mentions","strength":0.8,"evidence":"Gene target: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-progranulin-replacement-therapy-ftd","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-ftd-microglia-role-protective-destructive","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-autoimmune-hypothesis-ad","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"mentions","strength":0.8,"evidence":"Gene target: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-cognitive-fluctuation-mechanism","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"mentions","strength":0.8,"evidence":"Gene target: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-microglial-aging-immune-memory","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"hypothesis-h-d2df6eaf","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-d40d2659","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-969bd8e0","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"hypothesis-h-7e0b5ade","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"hypothesis-h-62e56eb9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Clearance'"},{"target_artifact_id":"hypothesis-h-637a53c9","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-58e4635a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-1acdd55e","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-ac55ff26","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"hypothesis-h-1e2bd420","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"hypothesis-h-6ce4884a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'mediated'"},{"target_artifact_id":"hypothesis-h-d7121bcc","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-881362dc","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-fd52a7a0","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Pathway'"},{"target_artifact_id":"hypothesis-h-74777459","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Mediated'"},{"target_artifact_id":"analysis-sda-2026-04-01-001","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'TREM2'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'amyloid'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'amyloid'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'clearance'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'clearance'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mediated'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'amyloid'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-amyloid-resilient-phenotype","link_type":"mentions","strength":0.5,"evidence":"Content: APOE mentioned 8x in wiki/mechanisms-trem2-amyloid-clearance-pathway"},{"target_artifact_id":"experiment-exp-wiki-experiments-sex-differences-alzheimers","link_type":"mentions","strength":0.5,"evidence":"Content: APOE mentioned 8x in wiki/mechanisms-trem2-amyloid-clearance-pathway"},{"target_artifact_id":"experiment-exp-wiki-experiments-ad-combination-therapy-trial","link_type":"mentions","strength":0.5,"evidence":"Content: APOE mentioned 8x in wiki/mechanisms-trem2-amyloid-clearance-pathway"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.7,"evidence":"Gene match: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-ftld-tau-tdp-biomarker-differentiation","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-mixed-pathology-pd-progression","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-intracellular-vs-extracellular-comparis","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-tau-pet-therapeutic-response-prediction","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-cbs-psp-phenotype-determinants","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-treatment-response-biomarkers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-tht-validation-protein-aggregation","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-vs-tau-pet-monitoring","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-dlb-genetic-modifiers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-toxin-microbiome-parkinsons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-microglial-immune-hd","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-debate-ca942ead922d","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-debate-a758632b9d36","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-oligodendrocyte-myelin-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-neural-oscillation-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-proteasome-ubiquitin-system-dysfunction-parkinso","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-microbiome-alpha-synuclein-propagation","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-stress-granule-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"related","strength":0.7,"evidence":"Wiki page for TREM2 related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-animal-model-comparison-neurodegeneration","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-protein-aggregation-kinetic-validation","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-non-motor-symptom-progression-pd","link_type":"related","strength":0.7,"evidence":"Wiki page for REM related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-tht-validation-protein-aggregation","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for TREM2 related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-endocannabinoid-system-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-glymphatic-circadian-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-regulated-necrosis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"related","strength":0.7,"evidence":"Wiki page for TREM2 related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-purinergic-signaling-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ID related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.6,"evidence":"Entity name match: TREM2"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"mentions","strength":0.6,"evidence":"Entity name match: TREM2"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"mentions","strength":0.6,"evidence":"Entity name match: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-senescent-clearance-neuro","link_type":"mentions","strength":0.4,"evidence":"Keyword match: clearance"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'APOE'"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'APOE'"},{"target_artifact_id":"hypothesis-h-15336069","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions hypothesis target gene 'APOE'"},{"target_artifact_id":"hypothesis-h-62e56eb9","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"related","strength":0.35,"evidence":"Title keyword"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"related","strength":0.7,"evidence":"Wiki title matches hypothesis target gene: trem2"},{"target_artifact_id":"hypothesis-h-51e7234f","link_type":"related","strength":0.5,"evidence":"Wiki content mentions gene MTOR"},{"target_artifact_id":"hypothesis-h-aa8b4952","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Mitochondrial calcium uniporter pathway"},{"target_artifact_id":"hypothesis-h-c8ccbee8","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Aquaporin-4 water transport / glymphatic clearance"},{"target_artifact_id":"hypothesis-h-84808267","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: LRP1 receptor-mediated transcytosis"},{"target_artifact_id":"hypothesis-h-7e0b5ade","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: LRP1 receptor-mediated transcytosis"},{"target_artifact_id":"hypothesis-h-ae1b2beb","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"target_artifact_id":"hypothesis-h-5e68b4ad","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"target_artifact_id":"hypothesis-h-58e4635a","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: C1q / complement-mediated synapse elimination"},{"target_artifact_id":"hypothesis-h-807d7a82","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Aquaporin-4 water transport / glymphatic clearance"},{"target_artifact_id":"hypothesis-h-3f02f222","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"target_artifact_id":"hypothesis-h-470ff83e","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"target_artifact_id":"hypothesis-h-83efeed6","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Circadian rhythm / glymphatic clearance"},{"target_artifact_id":"hypothesis-h-38292315","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"target_artifact_id":"hypothesis-h-9e9fee95","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Circadian rhythm / glymphatic clearance"},{"target_artifact_id":"hypothesis-h-de579caf","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Circadian rhythm / glymphatic clearance"},{"target_artifact_id":"hypothesis-h-4113b0e8","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"target_artifact_id":"hypothesis-h-8597755b","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"target_artifact_id":"hypothesis-h-441b25ba","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Beta-secretase / amyloidogenic pathway"},{"target_artifact_id":"hypothesis-h-4dd0d19b","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: LRP1 receptor-mediated transcytosis"},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"target_artifact_id":"hypothesis-h-0f00fd75","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"target_artifact_id":"hypothesis-h-73e29e3a","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: TREM2/TYROBP microglial activation → senescence transition"},{"target_artifact_id":"hypothesis-h-e3e8407c","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: TFEB-mediated lysosomal biogenesis / PGC1α mitochondrial biogenesis coupling"},{"target_artifact_id":"hypothesis-h-a4e259e0","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Vagal cholinergic anti-inflammatory pathway (α7nAChR)"},{"target_artifact_id":"hypothesis-h-8b7727c1","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Bacterial curli amyloid → α-synuclein cross-seeding (gut-brain axis)"},{"target_artifact_id":"hypothesis-h-2a4e4ad2","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: BNIP3/BNIP3L receptor-mediated mitophagy (PINK1/Parkin-independent)"},{"target_artifact_id":"hypothesis-h-54b9e0f5","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: Heparan sulfate proteoglycan-mediated amyloid templating"},{"target_artifact_id":"hypothesis-h-c9486869","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: HSP70-HSP40 (DNAJB6) chaperone-mediated amyloid inhibition"},{"target_artifact_id":"hypothesis-h-5d943bfc","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: HSP70/HSP40 chaperone-mediated proteostasis"},{"target_artifact_id":"hypothesis-h-c9c79e3e","link_type":"related","strength":0.65,"evidence":"Pathway page related to hypothesis pathway: APOE-mediated cholesterol/lipid transport"},{"target_artifact_id":"analysis-SDA-2026-04-04-gap-neuro-microglia-early-ad-20260404","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-prodromal-parkinson-biomarker-development","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-wiki-experiments-amyloid-removal-clinical-benefit-limited","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-debate-36966e7145ad","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp-debate-385d65cb42cb","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"experiment-exp_test_945f1101","link_type":"mentions","strength":0.8,"evidence":"Gene target: TREM2"},{"target_artifact_id":"experiment-exp_test_1f387354","link_type":"mentions","strength":0.8,"evidence":"Gene target: TREM2"},{"target_artifact_id":"experiment-exp_test_2d17a03f","link_type":"mentions","strength":0.8,"evidence":"Gene target: TREM2"},{"target_artifact_id":"experiment-exp_test_408325b7","link_type":"mentions","strength":0.8,"evidence":"Gene target: TREM2"},{"target_artifact_id":"experiment-exp_test_8773f9ef","link_type":"mentions","strength":0.8,"evidence":"Gene target: TREM2"},{"target_artifact_id":"experiment-exp_test_b803d750","link_type":"mentions","strength":0.8,"evidence":"Gene target: TREM2"},{"target_artifact_id":"experiment-exp_test_57bc9baa","link_type":"mentions","strength":0.8,"evidence":"Gene target: TREM2"},{"target_artifact_id":"wiki-biomarkers-strem2-soluble-trem2","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-biomarkers-strem2","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-clinical-trials-al002-trem2-agonist-alzheimers","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-entities-trem2","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-trem2-als","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-trem2-gene-mechanism-therapy-chain","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"wiki-mechanisms-trem2-ftd","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'clearance'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-astrocyte-subtypes","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TREM2"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'mechanisms'"}],"incoming_links":[{"source_artifact_id":"experiment-exp-wiki-experiments-tau-pet-therapeutic-response-prediction","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-ftld-tau-tdp-biomarker-differentiation","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-mixed-pathology-pd-progression","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-anti-tau-intracellular-vs-extracellular-comparis","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-cbs-psp-phenotype-determinants","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-dlb-treatment-response-biomarkers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-psp-cbs-biomarker-validation","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-anti-tau-therapy-failure-psp","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-blood-biomarker-vs-tau-pet-monitoring","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-dlb-genetic-modifiers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-toxin-microbiome-parkinsons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-microglial-immune-hd","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-debate-ca942ead922d","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-debate-a758632b9d36","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"hypothesis-h-61196ade","link_type":"related","strength":0.54,"evidence":"Reverse: Entity name match: TREM2"},{"source_artifact_id":"hypothesis-h-3460f820","link_type":"related","strength":0.54,"evidence":"Reverse: Entity name match: TREM2"},{"source_artifact_id":"hypothesis-h-180807e5","link_type":"related","strength":0.54,"evidence":"Reverse: Entity name match: TREM2"},{"source_artifact_id":"hypothesis-h-aa8b4952","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Mitochondrial calcium uniporter pathway"},{"source_artifact_id":"hypothesis-h-c8ccbee8","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Aquaporin-4 water transport / glymphatic clearance"},{"source_artifact_id":"hypothesis-h-84808267","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: LRP1 receptor-mediated transcytosis"},{"source_artifact_id":"hypothesis-h-ae1b2beb","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"source_artifact_id":"hypothesis-h-5e68b4ad","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Autophagy-lysosome pathway"},{"source_artifact_id":"hypothesis-h-807d7a82","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Aquaporin-4 water transport / glymphatic clearance"},{"source_artifact_id":"hypothesis-h-3f02f222","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"source_artifact_id":"hypothesis-h-470ff83e","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"source_artifact_id":"hypothesis-h-83efeed6","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Circadian rhythm / glymphatic clearance"},{"source_artifact_id":"hypothesis-h-38292315","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"source_artifact_id":"hypothesis-h-9e9fee95","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Circadian rhythm / glymphatic clearance"},{"source_artifact_id":"hypothesis-h-de579caf","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Circadian rhythm / glymphatic clearance"},{"source_artifact_id":"hypothesis-h-4113b0e8","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"source_artifact_id":"hypothesis-h-8597755b","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Microglial activation / TREM2 signaling"},{"source_artifact_id":"hypothesis-h-441b25ba","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Beta-secretase / amyloidogenic pathway"},{"source_artifact_id":"hypothesis-h-4dd0d19b","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: LRP1 receptor-mediated transcytosis"},{"source_artifact_id":"hypothesis-h-0f00fd75","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"source_artifact_id":"hypothesis-h-73e29e3a","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Tau protein / microtubule-associated pathway"},{"source_artifact_id":"hypothesis-h-e3e8407c","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: TFEB-mediated lysosomal biogenesis / PGC1α mitochondrial biogenesis coupling"},{"source_artifact_id":"hypothesis-h-a4e259e0","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Vagal cholinergic anti-inflammatory pathway (α7nAChR)"},{"source_artifact_id":"hypothesis-h-8b7727c1","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Bacterial curli amyloid → α-synuclein cross-seeding (gut-brain axis)"},{"source_artifact_id":"hypothesis-h-2a4e4ad2","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: BNIP3/BNIP3L receptor-mediated mitophagy (PINK1/Parkin-independent)"},{"source_artifact_id":"hypothesis-h-54b9e0f5","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: Heparan sulfate proteoglycan-mediated amyloid templating"},{"source_artifact_id":"hypothesis-h-c9486869","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: HSP70-HSP40 (DNAJB6) chaperone-mediated amyloid inhibition"},{"source_artifact_id":"hypothesis-h-5d943bfc","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: HSP70/HSP40 chaperone-mediated proteostasis"},{"source_artifact_id":"hypothesis-h-c9c79e3e","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Pathway page related to hypothesis pathway: APOE-mediated cholesterol/lipid transport"},{"source_artifact_id":"analysis-SDA-2026-04-04-gap-neuro-microglia-early-ad-20260404","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-prodromal-parkinson-biomarker-development","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-amyloid-removal-clinical-benefit-limited","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-debate-36966e7145ad","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-debate-385d65cb42cb","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp_test_945f1101","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TREM2"},{"source_artifact_id":"experiment-exp_test_1f387354","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TREM2"},{"source_artifact_id":"experiment-exp_test_2d17a03f","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TREM2"},{"source_artifact_id":"experiment-exp_test_408325b7","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TREM2"},{"source_artifact_id":"experiment-exp_test_8773f9ef","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TREM2"},{"source_artifact_id":"experiment-exp_test_b803d750","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TREM2"},{"source_artifact_id":"experiment-exp_test_57bc9baa","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-04-gap-neuroinflammation-microglial-20260404","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-11-gap-debate-20260410-111113-052488a8","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-11-gap-debate-20260410-112636-141592ba","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.8,"evidence":"Hypothesis involves entity 'TREM2' with wiki page"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.8,"evidence":"Hypothesis involves entity 'TREM2' with wiki page"},{"source_artifact_id":"hypothesis-h-b948c32c","link_type":"related","strength":0.5913,"evidence":"Reverse: Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-44195347","link_type":"related","strength":0.6048,"evidence":"Reverse: Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-d0a564e8","link_type":"related","strength":0.5796,"evidence":"Reverse: Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-11795af0","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-99b4e2d2","link_type":"related","strength":0.5679000000000001,"evidence":"Reverse: Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-a20e0cbb","link_type":"related","strength":0.6075,"evidence":"Reverse: Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-044ee057","link_type":"related","strength":0.5922000000000001,"evidence":"Reverse: Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.63,"evidence":"Reverse: Mechanism wiki 'TREM2-Mediated Amyloid Clearance Pathway' references gene/pathway from hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-immune-atlas-neuroinflam-20260402","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-trem2-function-alzheimers","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-progranulin-replacement-therapy-ftd","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-ftd-microglia-role-protective-destructive","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-autoimmune-hypothesis-ad","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-parkinsons","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-dlb-cognitive-fluctuation-mechanism","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-trem2-agonist-efficacy","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: TREM2"},{"source_artifact_id":"experiment-exp-wiki-experiments-microglial-aging-immune-memory","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"hypothesis-h-seaad-51323624","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TREM2 described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-oligodendrocyte-myelin-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-neural-oscillation-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-proteasome-ubiquitin-system-dysfunction-parkinso","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-microbiome-alpha-synuclein-propagation","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-stress-granule-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-animal-model-comparison-neurodegeneration","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-protein-aggregation-kinetic-validation","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-non-motor-symptom-progression-pd","link_type":"related","strength":0.7,"evidence":"Experiment targets REM described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-tht-validation-protein-aggregation","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-endocannabinoid-system-dysfunction-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-glymphatic-circadian-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-regulated-necrosis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-purinergic-signaling-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ID described in wiki"},{"source_artifact_id":"hypothesis-h-d2df6eaf","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-d40d2659","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-969bd8e0","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-7e0b5ade","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-62e56eb9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-637a53c9","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-58e4635a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1acdd55e","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-ac55ff26","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-1e2bd420","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-6ce4884a","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-d7121bcc","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-881362dc","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-fd52a7a0","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-74777459","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-18a0fcc6","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-004","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-012","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-013","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401231108","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-auto-fd6b1635d9","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-18cf98ca","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-bc5f270e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-20260402025452","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-seaad-v2-20260402032945","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-senescent-clearance-neuro","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-001","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-008","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-v2-ee5a5023","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"wiki-biomarkers-strem2-soluble-trem2","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-biomarkers-strem2","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-clinical-trials-al002-trem2-agonist-alzheimers","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-entities-trem2","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-trem2-als","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-trem2-gene-mechanism-therapy-chain","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"wiki-mechanisms-trem2-ftd","link_type":"see_also","strength":0.45,"evidence":"Pages share 3 hypotheses"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-20260402-003058","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-001","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-astrocyte-subtypes","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TREM2"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-aging-mouse-brain-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-mechanisms-trem2-amyloid-clearance-pathway","is_canonical":true,"supersede_chain":["wiki-mechanisms-trem2-amyloid-clearance-pathway"]}