{"artifact":{"id":"wiki-proteins-gsk3b","artifact_type":"wiki_page","entity_ids":"[\"GSK3B\"]","title":"GSK3B (Glycogen Synthase Kinase 3 Beta)","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"738f86883f265785e726fa5f98114a283fdd8cf4b2f7e5906dd084dd5d55180a","metadata":{"slug":"proteins-gsk3b","kg_node_id":"GSK3B","entity_type":"protein","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-998357831d33","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"proteins-gsk3b"},"_schema_version":1},"created_at":"2026-04-02T07:19:11-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"156437f1-6d70-4706-9b93-8db55490f169","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"hypothesis-h-dca3e907","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Kinase'"},{"target_artifact_id":"hypothesis-h-346639e8","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'proteins'"},{"target_artifact_id":"hypothesis-h-fdb07848","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Synthase'"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'proteins'"},{"target_artifact_id":"hypothesis-h-f99ce4ca","link_type":"mentions","strength":0.5,"evidence":"Entity 'GSK3B' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'GSK3B'"},{"target_artifact_id":"hypothesis-h-0f00fd75","link_type":"mentions","strength":0.5,"evidence":"Entity 'GSK3B' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'GSK3B'"},{"target_artifact_id":"hypothesis-h-62f9fc90","link_type":"mentions","strength":0.5,"evidence":"Entity 'GSK3B' mentioned in hypothesis description/evidence"},{"target_artifact_id":"hypothesis-h-0e675a41","link_type":"mentions","strength":0.5,"evidence":"Entity 'GSK3B' mentioned in hypothesis description/evidence"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'GSK3B'"},{"target_artifact_id":"hypothesis-h-7bb47d7a","link_type":"mentions","strength":0.9,"evidence":"Wiki page mentions gene TH targeted by hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-69919c49","link_type":"mentions","strength":0.5,"evidence":"KG transitive via PARP1"},{"target_artifact_id":"hypothesis-h-5706bbd7","link_type":"mentions","strength":0.5,"evidence":"KG transitive via BMAL1"},{"target_artifact_id":"hypothesis-h-019ad538","link_type":"mentions","strength":0.5,"evidence":"KG transitive via CLOCK"},{"target_artifact_id":"hypothesis-h-b7898b79","link_type":"mentions","strength":0.5,"evidence":"KG transitive via CLOCK"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-b295a9dd","link_type":"mentions","strength":0.5,"evidence":"KG transitive via LAMP1"},{"target_artifact_id":"hypothesis-h-0791836f","link_type":"mentions","strength":0.5,"evidence":"KG transitive via RAB7A"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.5,"evidence":"KG transitive via TREM2"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.5,"evidence":"KG transitive via TREM2"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.5,"evidence":"KG transitive via TREM2"},{"target_artifact_id":"hypothesis-h-43f72e21","link_type":"mentions","strength":0.5,"evidence":"KG transitive via PRKAA1"},{"target_artifact_id":"hypothesis-h-fd1562a3","link_type":"mentions","strength":0.5,"evidence":"KG transitive via COX4I1"},{"target_artifact_id":"hypothesis-h-441b25ba","link_type":"mentions","strength":0.5,"evidence":"KG transitive via BACE1"},{"target_artifact_id":"hypothesis-h-4dd0d19b","link_type":"mentions","strength":0.5,"evidence":"KG transitive via LRP1"},{"target_artifact_id":"hypothesis-h-856feb98","link_type":"mentions","strength":0.5,"evidence":"KG transitive via BDNF"},{"target_artifact_id":"hypothesis-h-seaad-56fa6428","link_type":"mentions","strength":0.5,"evidence":"KG transitive via GFAP"},{"target_artifact_id":"hypothesis-h-075f1f02","link_type":"mentions","strength":0.5,"evidence":"Wiki page 'GSK3B (Glycogen Synthase Kinase 3 Beta)' — entity matches hypothesis target"},{"target_artifact_id":"wiki-genes-abca1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-genes-abca2","link_type":"see_also","strength":0.6,"evidence":"KG edge: degrades"},{"target_artifact_id":"wiki-genes-adrb2","link_type":"see_also","strength":0.6,"evidence":"KG edge: interacts_with"},{"target_artifact_id":"wiki-mechanisms-aging-vs-neurodegeneration-comparison","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"target_artifact_id":"wiki-genes-aifm1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"mentions","strength":0.35,"evidence":"Via hypothesis description entity 'GSK3B'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-009","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-007","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-011","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-51e7234f","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene MTOR"},{"target_artifact_id":"hypothesis-h-e7e1f943","link_type":"related","strength":0.5,"evidence":"Wiki relates to pathway: NLRP3 inflammasome activation"},{"target_artifact_id":"hypothesis-h-8f285020","link_type":"related","strength":0.55,"evidence":"Shared KG edge: AGER → GSK3B"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-7bb47d7a","link_type":"related","strength":0.9,"evidence":"Hypothesis targets gene TH described in wiki"},{"source_artifact_id":"hypothesis-h-dca3e907","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-346639e8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-fdb07848","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-f99ce4ca","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-0f00fd75","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-62f9fc90","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-0e675a41","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-lipid-rafts-2026-04-01","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-691b42f1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-v2-5d0e3052","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-20260401-225149","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"open_question-proteins-gsk3b-f04448f9","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-proteins-gsk3b-2cd9e5b1","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-proteins-gsk3b-b3ed98ea","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-proteins-gsk3b-88d0ca18","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"}],"current_artifact_id":"wiki-proteins-gsk3b","is_canonical":true,"supersede_chain":["wiki-proteins-gsk3b"]}