{"artifact":{"id":"wiki-proteins-spr","artifact_type":"wiki_page","entity_ids":"[\"SPR\"]","title":"Sepiapterin Reductase (SPR)","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"36e13fa559d9147177b755b732c4799021a06c71debd451d80e070d243da9535","metadata":{"slug":"proteins-spr","kg_node_id":"SPR","entity_type":"protein","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-8afa3f552d66","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"proteins-spr"},"_schema_version":1},"created_at":"2026-04-02T07:19:14-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"9466df93-404a-4882-a1a0-6891988a42d4","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"experiment-exp-8c4df498-6bf5-43f0-a8b5-f742a5159986","link_type":"mentions","strength":0.7,"evidence":"Gene mention: SPR"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-005","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions analysis sda-2026-04-01-gap-005: ...P vs CBD](/analysis/SDA-2026-04-01-gap-005) &#x1f504;\n- [CRISP..."},{"target_artifact_id":"hypothesis-h-63b7bacd","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-63b7bacd: ...btypes](/hypothesis/h-63b7bacd) — <span style=\"col..."},{"target_artifact_id":"hypothesis-h-6657f7cd","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-6657f7cd: ...amming](/hypothesis/h-6657f7cd) — <span style=\"col..."},{"target_artifact_id":"hypothesis-h-c8ccbee8","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-c8ccbee8: ...Rescue](/hypothesis/h-c8ccbee8) — <span style=\"col..."},{"target_artifact_id":"hypothesis-h-e6437136","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-e6437136: ...lation](/hypothesis/h-e6437136) — <span style=\"col..."},{"target_artifact_id":"hypothesis-h-5a55aabc","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-5a55aabc: ...tching](/hypothesis/h-5a55aabc) — <span style=\"col..."},{"target_artifact_id":"hypothesis-h-c35493aa","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-c35493aa: ...herapy](/hypothesis/h-c35493aa) — <span style=\"col..."},{"target_artifact_id":"hypothesis-h-3a4f2027","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-3a4f2027: ...geting](/hypothesis/h-3a4f2027) — <span style=\"col..."},{"target_artifact_id":"hypothesis-h-5daecb6e","link_type":"mentions","strength":1.0,"evidence":"Wiki page mentions hypothesis h-5daecb6e: ...amming](/hypothesis/h-5daecb6e) — <span style=\"col..."},{"target_artifact_id":"hypothesis-h-346639e8","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'proteins'"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'proteins'"},{"target_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for ER related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-epigenetic-dysregulation-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for EPI related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Wiki page for CT related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"mentions","strength":0.5,"evidence":"KG transitive via HSPA1A"},{"target_artifact_id":"hypothesis-h-76888762","link_type":"mentions","strength":0.5,"evidence":"KG transitive via PPARGC1A"},{"target_artifact_id":"hypothesis-h-a1b56d74","link_type":"mentions","strength":0.5,"evidence":"KG transitive via HK2"},{"target_artifact_id":"hypothesis-h-38292315","link_type":"mentions","strength":0.5,"evidence":"KG transitive via HK2"},{"target_artifact_id":"hypothesis-h-725c62e9","link_type":"mentions","strength":0.5,"evidence":"KG transitive via PIEZO1"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-ac55ff26","link_type":"mentions","strength":0.5,"evidence":"KG transitive via ALOX15"},{"target_artifact_id":"hypothesis-h-4dd0d19b","link_type":"mentions","strength":0.5,"evidence":"KG transitive via LRP1"},{"target_artifact_id":"hypothesis-h-seaad-56fa6428","link_type":"mentions","strength":0.5,"evidence":"KG transitive via GFAP"},{"target_artifact_id":"hypothesis-h-seaad-v4-26ba859b","link_type":"mentions","strength":0.5,"evidence":"KG transitive via ACSL4"},{"target_artifact_id":"hypothesis-h-seaad-v4-29e81bbc","link_type":"mentions","strength":0.5,"evidence":"KG transitive via SLC16A1"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"mentions","strength":0.6,"evidence":"Wiki page 'Sepiapterin Reductase (SPR)' — entity mentioned in analysis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"mentions","strength":0.6,"evidence":"Wiki page 'Sepiapterin Reductase (SPR)' — entity mentioned in analysis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"mentions","strength":0.75,"evidence":"Wiki page 'Sepiapterin Reductase (SPR)' — entity mentioned in analysis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"mentions","strength":0.75,"evidence":"Wiki page 'Sepiapterin Reductase (SPR)' — entity mentioned in analysis"},{"target_artifact_id":"wiki-cell-types-acc-chronic-pain","link_type":"see_also","strength":0.6,"evidence":"KG edge: therapeutic_target"},{"target_artifact_id":"wiki-genes-acsl4","link_type":"see_also","strength":0.6,"evidence":"KG edge: therapeutic_target"},{"target_artifact_id":"wiki-mechanisms-aging-vs-neurodegeneration-comparison","link_type":"see_also","strength":0.6,"evidence":"KG edge: therapeutic_target"},{"target_artifact_id":"wiki-genes-akt1","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-genes-alox15","link_type":"see_also","strength":0.6,"evidence":"KG edge: therapeutic_target"},{"target_artifact_id":"wiki-hypotheses-apoe-contributes-alzheimers-disease-regulat","link_type":"see_also","strength":0.6,"evidence":"KG edge: therapeutic_target"},{"target_artifact_id":"wiki-entities-apoptosis","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"wiki-ideas-payload-app-dosage-reduction-ds-therapy","link_type":"see_also","strength":0.6,"evidence":"KG edge: inhibits"},{"target_artifact_id":"wiki-experiments-astrocyte-neuron-metabolic-coupling-parkinsons","link_type":"see_also","strength":0.6,"evidence":"KG edge: inhibits"},{"target_artifact_id":"wiki-genes-bax","link_type":"see_also","strength":0.6,"evidence":"KG edge: associated_with"},{"target_artifact_id":"analysis-analysis-SEAAD-20260402","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"hypothesis-h-seaad-v4-26ba859b","link_type":"related","strength":0.55,"evidence":"Shared KG edge: ACSL4 → SPR"},{"target_artifact_id":"hypothesis-h-ac55ff26","link_type":"related","strength":0.55,"evidence":"Shared KG edge: ALOX15 → SPR"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-014","link_type":"related","strength":0.5,"evidence":"{\"via\":\"hypothesis_parent\"}"},{"target_artifact_id":"experiment-exp-wiki-experiments-metal-ion-homeostasis-alzheimers","link_type":"mentions","strength":0.7,"evidence":"Gene mention: SPR"},{"target_artifact_id":"experiment-exp-debate-0a5edc59c7b9","link_type":"mentions","strength":0.7,"evidence":"Gene mention: SPR"}],"incoming_links":[{"source_artifact_id":"experiment-exp-wiki-experiments-metal-ion-homeostasis-alzheimers","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: SPR"},{"source_artifact_id":"experiment-exp-debate-0a5edc59c7b9","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: SPR"},{"source_artifact_id":"experiment-exp-8c4df498-6bf5-43f0-a8b5-f742a5159986","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: SPR"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"experiment-exp-wiki-experiments-er-golgi-secretory-pathway-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets ER described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-epigenetic-dysregulation-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets EPI described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-lipid-droplet-lysosome-axis-parkinsons","link_type":"related","strength":0.7,"evidence":"Experiment targets CT described in wiki"},{"source_artifact_id":"hypothesis-h-346639e8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-crispr-neurodegeneration-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-propagation-20260402","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-proteins-spr","is_canonical":true,"supersede_chain":["wiki-proteins-spr"]}