{"artifact":{"id":"wiki-proteins-tar-db-protein","artifact_type":"wiki_page","entity_ids":null,"title":"TDP-43 Protein","quality_score":0.5,"created_by":"crosslink-v2","provenance_chain":null,"content_hash":null,"metadata":{"origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-b1be96802ffe","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"proteins-tar-db-protein"},"_schema_version":1},"created_at":"2026-04-02T07:19:11-07:00","updated_at":"2026-04-02T17:00:58-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T10:00:35.667445-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"f17dc401-9e5f-433d-abc4-92931984a836","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-v2"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"analysis-sda-2026-04-01-gap-006","link_type":"related","strength":0.7,"evidence":"KG edge: TDP-43 --[regulates]--> RNA_splicing_pathway"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.7,"evidence":"KG edge: TDP-43 --[regulates]--> cryptic_exon_silencing"},{"target_artifact_id":"analysis-SDA-2026-04-12-gap-debate-20260410-113051-5dce7651","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"target_artifact_id":"analysis-SDA-2026-04-08-gap-pubmed-20260406-062207-5a703c17","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"target_artifact_id":"hypothesis-h-e6437136","link_type":"mentions","strength":0.65,"evidence":"Title match: TDP-43 Protein"},{"target_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"mentions","strength":0.65,"evidence":"Title match: TDP-43 Protein"},{"target_artifact_id":"hypothesis-h-69919c49","link_type":"mentions","strength":0.65,"evidence":"Title match: TDP-43 Protein"},{"target_artifact_id":"hypothesis-h-19003961","link_type":"mentions","strength":0.65,"evidence":"Title match: TDP-43 Protein"},{"target_artifact_id":"hypothesis-h-fffd1a74","link_type":"mentions","strength":0.65,"evidence":"Title match: TDP-43 Protein"},{"target_artifact_id":"hypothesis-h-dca3e907","link_type":"mentions","strength":0.65,"evidence":"Title match: TDP-43 Protein"},{"target_artifact_id":"hypothesis-h-69d383ea","link_type":"mentions","strength":0.65,"evidence":"Title match: TDP-43 Protein"},{"target_artifact_id":"hypothesis-h-7e846ceb","link_type":"mentions","strength":0.65,"evidence":"Title match: TDP-43 Protein"},{"target_artifact_id":"hypothesis-h-4fabd9ce","link_type":"mentions","strength":0.65,"evidence":"Title match: TDP-43 Protein"},{"target_artifact_id":"hypothesis-h-97aa8486","link_type":"mentions","strength":0.65,"evidence":"Title match: TDP-43 Protein"},{"target_artifact_id":"hypothesis-h-c463d225","link_type":"mentions","strength":0.65,"evidence":"Title match: TDP-43 Protein"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.65,"evidence":"Title match: TDP-43 Protein"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-wiki-experiments-ftld-tau-tdp-biomarker-differentiation","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-wiki-experiments-progranulin-tdp43-mechanism-ftd","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-wiki-experiments-progranulin-replacement-therapy-ftd","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-wiki-experiments-multiscale-protein-aggregation-modeling","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-wiki-experiments-viral-post-infectious-als-mechanism","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-wiki-experiments-tdp43-pet-ligand-development","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-wiki-experiments-frontal-temporal-selective-vulnerability-ftd","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-wiki-experiments-c9orf72-phenotype-divergence-als-ftd","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-wiki-experiments-prion-strain-diversity-cjd","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-wiki-experiments-autophagy-enhancement-drug-screening","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-debate-adc63499d52e","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-debate-7c7a8ed89fd3","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-debate-43e6de7dba33","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"hypothesis-h-346639e8","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'proteins'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'protein'"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'proteins'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'protein'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'protein'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.39,"evidence":"Transitive: wiki→hypothesis→analysis"},{"target_artifact_id":"hypothesis-h-addc0a61","link_type":"mentions","strength":0.65,"evidence":"Title match: TDP-43 Protein"},{"target_artifact_id":"experiment-exp-wiki-experiments-progranulin-tdp43-mechanism-ftd","link_type":"related","strength":0.7,"evidence":"Wiki page for TDP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-tdp43-pet-ligand-development","link_type":"related","strength":0.7,"evidence":"Wiki page for TDP related to experiment"},{"target_artifact_id":"experiment-exp-debate-adc63499d52e","link_type":"related","strength":0.7,"evidence":"Wiki page for TDP related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"hypothesis-h-eea667a9","link_type":"mentions","strength":0.5,"evidence":"KG transitive via TARDBP"},{"target_artifact_id":"hypothesis-h-a20e0cbb","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-44195347","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-d0a564e8","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-11795af0","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-99b4e2d2","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-seaad-fa5ea82d","link_type":"mentions","strength":0.5,"evidence":"KG transitive via APOE"},{"target_artifact_id":"hypothesis-h-ae1b2beb","link_type":"mentions","strength":0.5,"evidence":"KG transitive via FOXO1"},{"target_artifact_id":"hypothesis-h-5e68b4ad","link_type":"mentions","strength":0.5,"evidence":"KG transitive via STX17"},{"target_artifact_id":"hypothesis-h-b295a9dd","link_type":"mentions","strength":0.5,"evidence":"KG transitive via LAMP1"},{"target_artifact_id":"hypothesis-h-18a0fcc6","link_type":"mentions","strength":0.5,"evidence":"KG transitive via VCP"},{"target_artifact_id":"hypothesis-h-856feb98","link_type":"mentions","strength":0.5,"evidence":"KG transitive via BDNF"},{"target_artifact_id":"hypothesis-h-seaad-56fa6428","link_type":"mentions","strength":0.5,"evidence":"KG transitive via GFAP"},{"target_artifact_id":"wiki-mechanisms-aging-vs-neurodegeneration-comparison","link_type":"see_also","strength":0.6,"evidence":"KG edge: activates"},{"target_artifact_id":"hypothesis-h-7693c291","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TARDBP"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-006","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-wiki-experiments-als-progression-rate-heterogeneity","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-wiki-experiments-presymptomatic-grn-carrier-intervention-timing","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-wiki-experiments-als-regional-onset-spread","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-8575c9eb-9a3a-4d9a-9a26-ef9e8c110d94","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-d081efb0-0d00-49ff-80b2-4865e90992e1","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-62b2ebe2-1996-45ed-b23a-187423ff361f","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-aaf75848-e1d3-41b1-b131-3e2c13730e9c","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-9611670e-a7a5-48cc-a6cc-6d2aa0ddce50","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-f3173807-127f-4beb-abfc-64d934416c78","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-1f297f00-3d27-4c16-bfb2-d68eae4e3108","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"},{"target_artifact_id":"experiment-exp-e211ffa3-de74-4b6e-bfc6-c31762ebe5dc","link_type":"mentions","strength":0.7,"evidence":"Gene mention: TDP"}],"incoming_links":[{"source_artifact_id":"analysis-sda-2026-04-01-gap-006","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-wiki-experiments-als-progression-rate-heterogeneity","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-wiki-experiments-presymptomatic-grn-carrier-intervention-timing","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-wiki-experiments-als-regional-onset-spread","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-8575c9eb-9a3a-4d9a-9a26-ef9e8c110d94","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-d081efb0-0d00-49ff-80b2-4865e90992e1","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-62b2ebe2-1996-45ed-b23a-187423ff361f","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-aaf75848-e1d3-41b1-b131-3e2c13730e9c","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-9611670e-a7a5-48cc-a6cc-6d2aa0ddce50","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-f3173807-127f-4beb-abfc-64d934416c78","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-1f297f00-3d27-4c16-bfb2-d68eae4e3108","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-e211ffa3-de74-4b6e-bfc6-c31762ebe5dc","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"analysis-SDA-2026-04-12-gap-debate-20260410-113051-5dce7651","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"analysis-SDA-2026-04-08-gap-pubmed-20260406-062207-5a703c17","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"hypothesis-h-e6437136","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TDP-43 Protein"},{"source_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TDP-43 Protein"},{"source_artifact_id":"hypothesis-h-69919c49","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TDP-43 Protein"},{"source_artifact_id":"hypothesis-h-19003961","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TDP-43 Protein"},{"source_artifact_id":"hypothesis-h-fffd1a74","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TDP-43 Protein"},{"source_artifact_id":"hypothesis-h-dca3e907","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TDP-43 Protein"},{"source_artifact_id":"hypothesis-h-69d383ea","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TDP-43 Protein"},{"source_artifact_id":"hypothesis-h-7e846ceb","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TDP-43 Protein"},{"source_artifact_id":"hypothesis-h-4fabd9ce","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TDP-43 Protein"},{"source_artifact_id":"hypothesis-h-97aa8486","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TDP-43 Protein"},{"source_artifact_id":"hypothesis-h-c463d225","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TDP-43 Protein"},{"source_artifact_id":"hypothesis-h-b234254c","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TDP-43 Protein"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-wiki-experiments-ftld-tau-tdp-biomarker-differentiation","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-wiki-experiments-progranulin-tdp43-mechanism-ftd","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-wiki-experiments-progranulin-replacement-therapy-ftd","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-wiki-experiments-multiscale-protein-aggregation-modeling","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-wiki-experiments-viral-post-infectious-als-mechanism","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-wiki-experiments-tdp43-pet-ligand-development","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-wiki-experiments-frontal-temporal-selective-vulnerability-ftd","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-wiki-experiments-c9orf72-phenotype-divergence-als-ftd","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-wiki-experiments-prion-strain-diversity-cjd","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-wiki-experiments-autophagy-enhancement-drug-screening","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-debate-adc63499d52e","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-debate-7c7a8ed89fd3","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"experiment-exp-debate-43e6de7dba33","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: TDP"},{"source_artifact_id":"hypothesis-h-346639e8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-addc0a61","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-005","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-gap-tau-prop-20260402003221","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"}],"current_artifact_id":"wiki-proteins-tar-db-protein","is_canonical":true,"supersede_chain":["wiki-proteins-tar-db-protein"]}