{"artifact":{"id":"wiki-proteins-tar-dna-binding-protein-43","artifact_type":"wiki_page","entity_ids":"[\"TARDNABINDINGPROTEIN43\"]","title":"TAR DNA-Binding Protein 43 (TDP-43)","quality_score":0.5,"created_by":"crosslink-migration","provenance_chain":"[]","content_hash":"ef91be65adc729b99b599ea29496c4e9a93809d8ad0098a6cd81641907f09011","metadata":{"slug":"proteins-tar-dna-binding-protein-43","kg_node_id":"TARDNABINDINGPROTEIN43","entity_type":"protein","origin_type":"v1_polymorphic_backfill","source_table":"wiki_pages","wiki_page_id":"wp-7093f7dcbe19","__merged_from":{"merged_at":"2026-05-13","unprefixed_id":"proteins-tar-dna-binding-protein-43"},"_schema_version":1},"created_at":"2026-04-02T07:19:14-07:00","updated_at":"2026-04-02T13:40:08-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-02T13:40:08-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"d9a81366-f071-4c14-b853-b379593aaa95","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-migration"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"analysis-SDA-2026-04-04-gap-epigenetic-reprog-b685190e","link_type":"mentions","strength":0.6,"evidence":"Gene mention: DNA"},{"target_artifact_id":"analysis-SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca","link_type":"mentions","strength":0.6,"evidence":"Gene mention: DNA"},{"target_artifact_id":"analysis-SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95","link_type":"mentions","strength":0.6,"evidence":"Gene mention: DNA"},{"target_artifact_id":"hypothesis-h-69919c49","link_type":"mentions","strength":0.65,"evidence":"Title match: TAR DNA-Binding Protein 43 (TDP-43)"},{"target_artifact_id":"hypothesis-h-19003961","link_type":"mentions","strength":0.65,"evidence":"Title match: TAR DNA-Binding Protein 43 (TDP-43)"},{"target_artifact_id":"hypothesis-h-fffd1a74","link_type":"mentions","strength":0.65,"evidence":"Title match: TAR DNA-Binding Protein 43 (TDP-43)"},{"target_artifact_id":"hypothesis-h-7e846ceb","link_type":"mentions","strength":0.65,"evidence":"Title match: TAR DNA-Binding Protein 43 (TDP-43)"},{"target_artifact_id":"hypothesis-h-4fabd9ce","link_type":"mentions","strength":0.65,"evidence":"Title match: TAR DNA-Binding Protein 43 (TDP-43)"},{"target_artifact_id":"hypothesis-h-eea667a9","link_type":"mentions","strength":0.65,"evidence":"Title match: TAR DNA-Binding Protein 43 (TDP-43)"},{"target_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Protein'"},{"target_artifact_id":"hypothesis-h-dca3e907","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'Protein'"},{"target_artifact_id":"hypothesis-h-346639e8","link_type":"mentions","strength":0.5,"evidence":"Wiki page title/slug matches hypothesis keyword 'proteins'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-010","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'binding'"},{"target_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'binding'"},{"target_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'proteins'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'protein'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"mentions","strength":0.4,"evidence":"Wiki page matches analysis keyword 'binding'"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.3,"evidence":"Transitive: wiki→hypothesis→analysis"},{"target_artifact_id":"experiment-exp-wiki-experiments-progranulin-tdp43-mechanism-ftd","link_type":"related","strength":0.7,"evidence":"Wiki page for TDP related to experiment"},{"target_artifact_id":"experiment-exp-wiki-experiments-tdp43-pet-ligand-development","link_type":"related","strength":0.7,"evidence":"Wiki page for TDP related to experiment"},{"target_artifact_id":"experiment-exp-debate-adc63499d52e","link_type":"related","strength":0.7,"evidence":"Wiki page for TDP related to experiment"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Auto: transitive via hypothesis"},{"target_artifact_id":"wiki-diseases-neurodegeneration","link_type":"see_also","strength":0.6,"evidence":"KG edge: implicated_in"},{"target_artifact_id":"hypothesis-h-27bc0569","link_type":"related","strength":0.5,"evidence":"Wiki content mentions gene G3BP1"},{"target_artifact_id":"hypothesis-h-fdaae8d9","link_type":"mentions","strength":0.65,"evidence":"Wiki page content mentions hypothesis target gene: NLGN1"},{"target_artifact_id":"hypothesis-h-ec731b7a","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene G3BP1"},{"target_artifact_id":"hypothesis-h-97aa8486","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene G3BP1"},{"target_artifact_id":"hypothesis-h-7693c291","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TARDBP"},{"target_artifact_id":"hypothesis-h-044ee057","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-b234254c","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-seaad-51323624","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-61196ade","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-3460f820","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-180807e5","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene TREM2"},{"target_artifact_id":"hypothesis-h-seaad-56fa6428","link_type":"mentions","strength":0.5,"evidence":"Wiki content mentions gene GFAP"},{"target_artifact_id":"hypothesis-h-27bc0569","link_type":"mentions","strength":0.7,"evidence":"Wiki content mentions gene G3BP1"}],"incoming_links":[{"source_artifact_id":"hypothesis-h-fdaae8d9","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Wiki page content mentions hypothesis target gene: NLGN1"},{"source_artifact_id":"hypothesis-h-27bc0569","link_type":"related","strength":0.63,"evidence":"Reverse: Wiki content mentions gene G3BP1"},{"source_artifact_id":"analysis-SDA-2026-04-04-gap-epigenetic-reprog-b685190e","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: DNA"},{"source_artifact_id":"analysis-SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: DNA"},{"source_artifact_id":"analysis-SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: DNA"},{"source_artifact_id":"hypothesis-h-69919c49","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TAR DNA-Binding Protein 43 (TDP-43)"},{"source_artifact_id":"hypothesis-h-19003961","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TAR DNA-Binding Protein 43 (TDP-43)"},{"source_artifact_id":"hypothesis-h-fffd1a74","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TAR DNA-Binding Protein 43 (TDP-43)"},{"source_artifact_id":"hypothesis-h-7e846ceb","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TAR DNA-Binding Protein 43 (TDP-43)"},{"source_artifact_id":"hypothesis-h-4fabd9ce","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TAR DNA-Binding Protein 43 (TDP-43)"},{"source_artifact_id":"hypothesis-h-eea667a9","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: Title match: TAR DNA-Binding Protein 43 (TDP-43)"},{"source_artifact_id":"experiment-exp-wiki-experiments-progranulin-tdp43-mechanism-ftd","link_type":"related","strength":0.7,"evidence":"Experiment targets TDP described in wiki"},{"source_artifact_id":"experiment-exp-wiki-experiments-tdp43-pet-ligand-development","link_type":"related","strength":0.7,"evidence":"Experiment targets TDP described in wiki"},{"source_artifact_id":"experiment-exp-debate-adc63499d52e","link_type":"related","strength":0.7,"evidence":"Experiment targets TDP described in wiki"},{"source_artifact_id":"hypothesis-h-5dbfd3aa","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-dca3e907","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"hypothesis-h-346639e8","link_type":"related","strength":0.4,"evidence":"Auto: reverse of wiki→hypothesis"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.6,"evidence":"Analysis discusses entity covered by wiki page"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-006","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-9137255b","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-01-gap-v2-89432b95","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-SDA-2026-04-02-26abc5e5f9f2","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-010","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"analysis-sda-2026-04-01-gap-v2-68d9c9c1","link_type":"related","strength":0.5,"evidence":"Reverse link"},{"source_artifact_id":"open_question-proteins-tar-dna-binding-protein-43-0d20b43b","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-proteins-tar-dna-binding-protein-43-35013c58","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-proteins-tar-dna-binding-protein-43-740246c3","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-proteins-tar-dna-binding-protein-43-24c5bcee","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"},{"source_artifact_id":"open_question-proteins-tar-dna-binding-protein-43-49402d63","link_type":"derives_from","strength":0.9,"evidence":"{\"method\": \"open_question_wiki_crosslink\", \"cycle\": \"artifact-enrichment-2026-04-27\"}"}],"current_artifact_id":"wiki-proteins-tar-dna-binding-protein-43","is_canonical":true,"supersede_chain":["wiki-proteins-tar-dna-binding-protein-43"]}